Beziehungen zwischen Histamingehalt und Aktivität der Histidindecarboxylase im Bereich von Hautverletzungen

Berg, S.; Ditt, J; Kunze, Peter C.; Garbe, G.

doi:10.1007/bf02092634

Cited by 21 publications

(1 citation statement)

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“…Histamine release in surgery by surgical trauma or injury is a problem which has really interested several generations of surgeons and specialists in many medical disciplines (Schneider 1930;Minard 1937;Dragstedt and Mead 1937;Mac Donald and Woolfe 1938;Rose and Browne 1940;Koslowski et al 1982;Spuzic and Halpern 1959;Rosenthal 1969;Berg et al 1971;Lorenz et al 1973;Lorenz et al 1974 Thermann et al 1978). Findings and hypothe-ses sometimes were in favour of a role of histamine in this stressful condition, sometimes against it, but without any exception all authors agree that this role has yet to be defined.…”

Section: Discussionmentioning

confidence: 99%

Plasma histamine levels in patients in the course of several standard operations: Influence of anaesthesia, surgical trauma and blood transfusion

et al. 1982

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Summary.A prospective controlled clinical trial was conducted on changes in plasma histamine and catecholamine levels during 5 standard operations. This communication, as the first part of the trial, deals only with the feasibility of such a trial and the changes in plasma histamine levels.Elevated histamine concentrations corresponding to histamine-release responses of > 1 ng/ml occurred in 8 of 25 operations. In an explorative analysis these reponses were associated with distinct phases of anaesthesia or the surgical procedure.Blood transfusion carried the risk of infusion of "free histamine" into the patient -especially when administerea under pressure.Since during operations "free histamine" enters the circulation with a rather high incidence and may cause harmful effects, premedication with Hl-+Hz-receptor antagonists seems worth consideration.Key words: Standard operations anaesthesia -blood transfusion -plasma histamine Plasmahistaminspiegel bei Patienten im Verlauf von versehiedenen Standardoperationen: Einflufl yon An/isthesie, chirurgisehem Trauma und BluttransfusionZusammenfassung. Eine prospektive kontrollierte klinische Studie wurde fiber Ver/inderungen des Plasmahistamin-und Katecholaminspiegels bei 5 Standardoperationen durchgeffihrt. Diese Mitteilung, als erster Teil der Studie, zeigt nur die M6gtichkeiten auf, eine solche Studie durchzuf/ihren und Ver/inderungen des Plasmahistaminspiegels nachzuweisen.Erh6hte Plasmahistaminkonzentrationen, die einer Histaminfreisetzungsreaktion yon > 1 ng/ml entsprechen, kamen bei 8 yon 25 Operationen vor. In einer explorativen statistischen Analyse wurden diese Reaktionen mit bestimmten Phasen der An/isthesie oder des chirurgischen Eingriffs in Verbindung gebracht.Bluttransfusionen tragen das Risiko in sich, ,,freies Histamin" in den Patienten zu infundieren -zumal bei Filterpassage, wenn es unter erhthtem Druck angewandt wird.

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