Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration

Zhang, Shufang; Chen, Longkun; Jiang, Yangzi; Cai, Youzhi; Xu, Guangyu; Tong, Tong; Zhang, Wei; Wang, Linlin; Ji, Junfeng; Shi, Peihua; Ouyang, Hong

doi:10.1016/j.actbio.2013.04.003

Cited by 114 publications

(69 citation statements)

References 33 publications

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“…To promote regeneration of the tracheal epithelium without a cell source, gel scaffold or growth factor was impregnated into gelatin hydrogel for tracheal defect repair [14,28,29]. Recently, collagen has been used for osteochondral regeneration [30][31][32], and in the present study, PC-NF with or without hUCS showed good cartilage regeneration. Based on the concept that a combination of bioactive growth factors is likely necessary for cartilage repair, we used PC-NF coated with hUCS, which has many growth factors.…”

Section: Discussionmentioning

confidence: 80%

Tracheal regeneration using polycaprolactone/collagen-nanofiber coated with umbilical cord serum after partial resection

Jang¹,

Jang

Cho

et al. 2014

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 80%

Tracheal regeneration using polycaprolactone/collagen-nanofiber coated with umbilical cord serum after partial resection

Jang¹,

Jang

Cho

et al. 2014

International Journal of Pediatric Otorhinolaryngology

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“…These can broadly be divided into natural or synthetic scaffolds. Natural scaffolds include substances such as carbohydrate-based materials such as chitosan (Ye et al 2014;García Cruz et al 2012;Alves da Silva et al 2011), hyaluronate (Son et al 2013;Toh et al 2012) or even protein-based structures such as collagen (Zhang et al 2012(Zhang et al , 2013aMurphy et al 2012), fibrin (Diederichs et al 2012;Park et al 2011), gelatin (Klangjorhor et al 2012;Pruksakorn et al 2009) and chondroitin (Chen et al 2013;Park et al 2010;Varghese et al 2008). Synthetic scaffolds successfully used include polyglycolic acid, polylactic acid, poly(lactic-co-glycolic acid), polyethylene glycol and polycaprolactone (Hidalgo et al 2013;Childs et al 2013;Zhang et al 2013b;Li et al 2013).…”

Section: Scaffoldsmentioning

confidence: 98%

Stem Cell Therapy for Cartilage Defects

Pastides

Khan

2015

Translational Medicine Research

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Cartilaginous defects within the articular cartilage present a treatment problem within the orthopaedic community. In cases of established osteoarthritis affecting large joints, arthroplasty is a good, well-established and predictable option. It is though a step too far for smaller and discrete lesions. Currently, surgical options include autologous chondrocyte implantation, microfracture, osteochondral autologous transplantation and even osteochondral allograft plugs. Tissue engineering techniques may prove to be the answer to this problem. There is plenty of interest in stem cell manipulation to induce chondrogenesis. The areas of research focus on the differentiation of multipotent mesenchymal stem cells but also more recently on the use of induced pluripotent stem cells. Furthermore, augmentation of repair can be facilitated by endogenous stimulants to these cells such as growth factors, gene therapy and scaffolds to maintain an optimum microenvironment. Endogenous stimulants aside, it does appear that exogenous methods of stimulation such as ultrasound and magnetic field applications can further augment and improve the reparative process. The aim of this chapter is to define the problem faced by the medical world due to the macro-and microscopic structure of cartilage and present data and reports showing the advances made in this field. The final section focuses on the current state of play surrounding the translation of these techniques to human subjects, presenting the up-to-date studies.

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“…11.8 Bone sialoprotein-collagen implantation into a rat cranial bone defect and new bone formation in the defect at 30th day after implantation (Kruger et al 2013). This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Recently, the collagen-PLA nanofibers were studied as a potential implant biopolymeric material for the treatment of deep osteochondral defects (Zhang et al 2013b). Another novel biomimetic fabrication technique has also been developed to prepare collagen-apatite implants with adjustable composition and pore size structures for bone formation.…”

Section: Collagen Implants: Bonementioning

confidence: 99%

Biopolymers in Medical Implants

Bhatt

Jaffé

2015

Excipient Applications in Formulation Design and Drug Delivery

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Many researchers are exploring the potential use of biopolymers as implants in a wide range of applications ranging from replacements of bone to the regeneration of nerves. Biocompatibility, biodegradability and versatility are the properties which make these biopolymers materials of choice. Studies in biopolymer based implants (till date) indicate significant developments in terms of innovative strategies and design of implants to regenerate/repair a damaged tissue or organ. This chapter reviews the present state-of-art of biopolymers and their applications as medical implants. Several biopolymers namely poly (3-hydroxyalkanoates), collagen, gelatin, chitosan and hyaluronic acid are discussed in detail with reference to their applications in orthopaedics, ophthalmology, cardiology, otolaryngology and a few others.

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Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration

Cited by 114 publications

References 33 publications

Tracheal regeneration using polycaprolactone/collagen-nanofiber coated with umbilical cord serum after partial resection

Tracheal regeneration using polycaprolactone/collagen-nanofiber coated with umbilical cord serum after partial resection

Stem Cell Therapy for Cartilage Defects

Biopolymers in Medical Implants

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