Bi-Metallic films of Gold, MXene, and Graphene nano film-based Surface Plasmon Resonance Sensor for Malaria Detection: A Numerical Analysis

Abstract

In this proposed work, an SPR-based biosensor with dual nanofilms of a gold metal, 2-Dimensional MXene, and graphene has been proposed to detect different malaria stages. The principal obeyed by the sensor design is attenuated total reflection (ATR) with a modified Kretschmann-based configuration. Numerical computational results give the higher sensitivity for our proposed design as 227.9 degree/RIU (for single MXene and dual graphene layers at RI variation of 1.33 to 1.38 with a change of 0.01) and 258.28 degree/RIU(for trophozoite stage of malaria disease), with other performance parameters like DA computed as equal to 0.14 degree-1 , QF as 31 RIU-1 and 35.5 RIU-1, FWHM as 7.35 degree and 7.27 degree for single MXene, dual graphene nanofilms and trophozoite stage respectively. The suggested biosensor can diagnose the various stages of severe malaria disease by measuring the refractive index alteration in red blood cells (RBCs).