Bias and precision of estimated glomerular filtration rate in children

Gretz, Norbert; D, Schock; Sadick, Maliha; Pill, Johannes

doi:10.1007/s00467-006-0379-9

Cited by 15 publications

(13 citation statements)

References 32 publications

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“…Moreover, the precision of all the four equations are not satisfactory, according to the Bland-Altman Analysis (shown in Fig 1). This is in concordance with the published studies[25]. Currently, we have to accept a precision (as defined in the Bland-Altman plot) of ±20% in adults and ±30–40% in children.…”

Section: Discussionsupporting

confidence: 87%

Validation of glomerular filtration rate-estimating equations in Chinese children

et al. 2017

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Section: Discussionsupporting

confidence: 87%

Validation of glomerular filtration rate-estimating equations in Chinese children

et al. 2017

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“…Most of the equations in children are based on serum creatinine levels determined by the Jaffé method [9], and many of these have been established based on results obtained in small cohorts; consequently, they may lack precision [10]. An additional complicating factor is that in young children the use of a GFR formula is made more difficult by the rapid increase in GFR during the first year of life—approximately 20 mL/min per 1.73 m 2 at birth to 80–120 mL/min per 1.73 m 2 at 12 months [11].…”

Section: Introductionmentioning

confidence: 99%

Reference values for serum creatinine in children younger than 1 year of age

et al. 2010

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Reliable reference values of enzymatically assayed serum creatinine categorized in small age intervals are lacking in young children. The aim of this study was to determine reference values for serum creatinine during the first year of life and study the influence of gender, weight and height on these values. Serum creatinine determinations between 2003 and 2008 were retrieved from the hospital database. Strict exclusion criteria ensured the selection of patients without kidney damage. Correlation analysis was performed to evaluate the relation between height, weight and serum creatinine; the Mann–Whitney test was used to evaluate the relation between gender and serum creatinine. A broken stick model was designed to predict normal serum creatinine values. Mean serum creatinine values were found to decrease rapidly from 55 μmol/L on day 1 to 22 μmol/L in the second month of life; they then stabilized at 20 μmol/L until the seventh month, followed by a slight increase. No significant relation was found between serum creatinine and gender, weight and height. We present here reference values of serum creatinine in infants not at risk of decreased renal function. The absence of a relationship with gender, weight and height confirms that height-based equations to estimate glomerular filtration rate are less useful in patients of this age group.

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“…In paediatric clinical practice, GFR has traditionally been estimated by serum or urine creatininebased methods. These methods, utilizing creatinine as a filtration marker, have well recognized inherent problems [2,3], which are amplified in children with spina bifida.…”

Section: Introductionmentioning

confidence: 99%

Correlation between cystatin C- and renal scan-determined glomerular filtration rate in children with spina bifida

et al. 2007

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We report on the relationships between serum cystatin C level, glomerular filtration rate (GFR) estimated from a cystatin C-based prediction equation (that of Filler and Lepage), GFR calculated by the Schwartz formula and technetium 99m-diethylene triamine penta-acetic acid ((99)Tc-DTPA)-determined GFR in 28 children with spina bifida. All children underwent measurement of height, weight, serum cystatin C level, and serum creatinine level at the time of their renal scan. The relationship between variables was assessed by Pearson correlation. Pearson correlation for the relationship between (99)Tc-DTPA GFR and GFR calculated by the cystatin C-based equation was significant and higher than that of the relationship between (99)Tc-DTPA GFR and GFR calculated by the Schwartz equation, which was not statistically significant. The correlation for Filler GFR was 0.42 (P = 0.03) and for Schwartz GFR was 0.21 (P = 0.28). Although we use renal scan determination of GFR as the best measure, and a creatinine-based formula as the most practical measure, perhaps a formula such as that published by Filler and Lepage, which is not dependent on anthropometric data, might be a more useful (and accurate) tool for establishing GFR in children with spina bifida.

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Bias and precision of estimated glomerular filtration rate in children

Cited by 15 publications

References 32 publications

Validation of glomerular filtration rate-estimating equations in Chinese children

Validation of glomerular filtration rate-estimating equations in Chinese children

Reference values for serum creatinine in children younger than 1 year of age

Correlation between cystatin C- and renal scan-determined glomerular filtration rate in children with spina bifida

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