Biaxial Mechanical Properties of the Human Thoracic And Abdominal Aorta, Common Carotid, Subclavian, Renal and Common Iliac Arteries

Kamenskiy, Alexey; Kazmi, Syed A. Jaffar; Pemberton, Mark; Pipinos, Iraklis I.; Dzenis, Yuris A.; Lomneth, Carol; Phillips, Nick Y.; MacTaggart, Jason N.

doi:10.1016/j.jss.2013.11.730

Cited by 17 publications

(35 citation statements)

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“…However, Holzapfel et al (2005) found that the intima and adventitia of coronaries show the most pronounced nonlinearity and anisotropy in contrast to our aorta data. Planar biaxial testing is a common approach to characterizing arteries and our results show the anisotropy of the aorta like other studies (Kamenskiy et al, 1998 11 -Mean biaxial tensile stress-stretch curves of (a) upper and (b) lower thoracic aorta (symbols) and simulation results (solid and dashed black lines) with the uniaxial material parameters. Colored areas represent p40:1 and po0:9 of the biaxial experimental data (brown for circumferential direction and grey for longitudinal direction).…”

Section: Discussionsupporting

confidence: 75%

“…Experimental procedures such as inflation tests (Barra et al, 1993;Kim and Baek, 2011;Lillie et al, 2012;Lu et al, 2003), simple uniaxial tension (Silver et al, 2003;Sokolis, 2010;Weisbecker et al, 2012), and biaxial tests (Kamenskiy et al, 1998;Lally et al, 2004;Zeinali-Davarani et al, 2013) have been used to determine the mechanical properties of aortic tissues. It is now widely accepted that arterial tissue undergoes large deformations and is highly nonlinear and anisotropic.…”

Section: Uniaxial and Biaxial Testingmentioning

confidence: 99%

“…To measure the nonlinearity, longitudinal and the circumferential stretches at 50% of this physiological pressure was computed. Finally, anisotropy was analyzed by the difference in longitudinal and circumferential stretches divided by their average value (Kamenskiy et al, 1998).…”

Section: Mechanical Testingmentioning

confidence: 99%

See 2 more Smart Citations

Layer-specific residual deformations and uniaxial and biaxial mechanical properties of thoracic porcine aorta

Peña

Martı́nez

Peña

2015

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Discussionsupporting

confidence: 75%

Section: Uniaxial and Biaxial Testingmentioning

confidence: 99%

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Layer-specific residual deformations and uniaxial and biaxial mechanical properties of thoracic porcine aorta

Peña

Martı́nez

Peña

2015

Journal of the Mechanical Behavior of Biomedical Materials

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“…Although the majority of the tissue specimens displayed preferential stiffening in the circumferential direction, variations in the preferred direction also existed within the test data. Due to the changes of the wall's structural components such as elastin and collagen as a result of aneurysm progression, anisotropy can be affected which has previously been observed in aortic aneurysmal tissues 38 and most other arteries 12 . Comparing our material coefficients to those acquired in a similar study of AAA by Vande Geest et al 38…”

Section: Constitutive Modelmentioning

confidence: 96%

“…The average and standard deviation values of tangential modulus and stretch ratio evaluated at 150kPa in both the circumferential and longitudinal directions for patient specific factors patient sex, age, AAA diameter and status. A p-value less than 0.05 indicates a statistically significant difference between the properties 12. 1.11 ± 0.02 1.12 ± 0.02 7.82 ± 2.71 6.42 ± 1.39 > 70 years 16 1.11 ± 0.03 1.12± 0.03 8.15 ± 3.37 6.98 ± 2.70…”

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confidence: 99%

The Biaxial Biomechanical Behavior of Abdominal Aortic Aneurysm Tissue

et al. 2014

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Rupture of the abdominal aortic aneurysm (AAA) occurs when the local wall stress exceeds the local wall strength. Knowledge of AAA wall mechanics plays a fundamental role in the development and advancement of AAA rupture risk assessment tools. Therefore, the aim of this study is to evaluate the biaxial mechanical properties of AAA tissue. Multiple biaxial test protocols were performed on AAA samples harvested from 28 patients undergoing open surgical repair. Both the Tangential Modulus (TM) and stretch ratio (λ) were recorded and compared in both the circumferential (ϴ) and longitudinal (L) directions at physiologically relevant stress levels, the influence of patient specific factors such as sex, age AAA diameter and status were examined. The biomechanical response was also fit to a hyperplastic material model. The AAA tissue was found to be anisotropic with a greater tendency to stiffen in the circumferential direction compared to the longitudinal direction. An anisotropic hyperelastic constitutive model represented the data well and the properties were not influenced by the investigated patient specific factors however, a future study utilizing a larger cohort of patients is warranted to confirm these findings. This work provides further insights on the biomechanical behavior of AAA and may be useful in the development of more reliable rupture risk assessment tools.

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Application of nondestructive mechanical characterization testing for creating in vitro vessel models with material properties similar to human neurovasculature

Norris

Merritt

Becker

2021

J Biomedical Materials Res

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Vessel models are a first step in developing endovascular medical devices. However, these models, often made from glass or silicone, do not accurately represent the mechanical properties of human vascular tissue, limiting their use to basic training and proof-of-concept testing. This study outlines methods to quantify human vascular tissue mechanical properties and synthetic biomaterials for creating representative vessel models. Human vascular tissue was assessed and compared to silicone and new UV-cured polymers (VC-A30) using the following eight mechanical tests: compressive, shear, tensile dynamic elastic modulus, Poisson's ratio, hardness, radial force, compliance, and lubricity. Half of these testing methods were nondestructive, allowing for multiple mechanical and histological characterizations of the same human tissue sample. Histological evaluation of the cellular and extracellular matrix of the human vessels verified that the dynamic moduli and Poison's ratio tests were nondestructive. Fluid absorption by VC-A30 showed statistically significant softening of mechanical properties, stabilizing after 4 days in phosphate-buffered saline (PBS).Human vasculature exhibited notably similar results to VC-A30 in five of eight mechanical tests (≤30% difference) versus two of eight for standard silicone (≤38% difference). Results show that VC-A30 provides a new option for 3D-printing translucent in vitro vascular models with anatomically relevant mechanical properties. These new vessel analogs may simulate patient-specific vessel disease states, improve surgical training models, accelerate new endovascular device developments, and ultimately reduce the need for animal models.

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Biaxial Mechanical Properties of the Human Thoracic And Abdominal Aorta, Common Carotid, Subclavian, Renal and Common Iliac Arteries

Cited by 17 publications

References 0 publications

Layer-specific residual deformations and uniaxial and biaxial mechanical properties of thoracic porcine aorta

Layer-specific residual deformations and uniaxial and biaxial mechanical properties of thoracic porcine aorta

The Biaxial Biomechanical Behavior of Abdominal Aortic Aneurysm Tissue

Application of nondestructive mechanical characterization testing for creating in vitro vessel models with material properties similar to human neurovasculature

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