Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications

Jiménez, Mirta; Abradelo, Cristina; Román, Julio San; Rojo, Luís

doi:10.1039/c8tb02738b

Cited by 85 publications

(55 citation statements)

References 108 publications

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“…The good outcomes of the ionic presence into the hierarchical scaffolds were confirmed by the similar porosity ( Figure 2B), trabecular thickness ( Figure 2C), and pore size distribution ( Figure 2D) of the BdTCP scaffolds to that obtained for the healthy controls. Moreover, in the subchondral bone region the BdTCP scaffolds were filled by hard and soft tissue at similar levels ( Figure 3A), which indicates the strong impact of Zn and Sr elements on bone formation and mineralization, by means of improving the microstructure and crystallinity of β-TCP [34,46].…”

Section: Integration and Oc Tissue Formation On The Hierarchical Scafmentioning

confidence: 73%

In Vivo Performance of Hierarchical HRP-Crosslinked Silk Fibroin/β-TCP Scaffolds for Osteochondral Tissue Regeneration

2019

Regen Med Front.

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Background: Osteochondral defects (OCD) can affect the articular cartilage and subchondral bone tissues, which requires superior therapies for the simultaneous and full restoration of such structurally and biologically different tissues. Methods: Tissue engineered OC grafts were prepared using a horseradish peroxidase (HRP) approach to crosslink silk fibroin (HRP-SF) as the articular cartilage-like layer and an underlying HRP-SF/ZnSrTCP subchondral bone-like layer (HRP-SF/dTCP), through salt-leaching/freezedrying methodologies. In vivo OC regeneration was assessed by implantating the hierarchical scaffolds in rabbit critical size OC defects, during 8 weeks. A comparative analysis was performed using hierarchical OC grafts made of pure β-TCP (HRP-SF/TCP). Results: The hierarchical scaffolds showed good integration into the host tissue and no signs of acute inflammatory reaction, after 8 weeks of implantation. The histological analyses revealed positive collagen type II and glycosaminoglycans' formation in the articular cartilage-like layer.

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Section: Integration and Oc Tissue Formation On The Hierarchical Scafmentioning

confidence: 73%

In Vivo Performance of Hierarchical HRP-Crosslinked Silk Fibroin/β-TCP Scaffolds for Osteochondral Tissue Regeneration

2019

Regen Med Front.

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“…It is of low cost, has a longer shelf life, and presents low systemic risk compared to growth factors. These added benefits make Sr as therapeutic agent attractive in tissue engineering and regenerative medicine applications (Jiménez et al, 2019;Prabha et al, 2019;Mao et al, 2020). However, the mechanism of osteoinduction of SrCaPs remains complicated because inflammation and angiogenesis accompany the entire process of bone healing.…”

Section: Resultsmentioning

confidence: 99%

Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics

Wan

Wang

Sun

et al. 2020

Front. Bioeng. Biotechnol.

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Bioceramics have experienced great development over the past 50 years. Modern bioceramics are designed to integrate bioactive ions within ceramic granules to trigger living tissue regeneration. Preclinical and clinical studies have shown that strontium is a safe and effective divalent metal ion for preventing osteoporosis, which has led to its incorporation in calcium phosphate-based ceramics. The local release of strontium ions during degradation results in moderate concentrations that trigger osteogenesis with few systemic side effects. Moreover, strontium has been proven to generate a favorable immune environment and promote early angiogenesis at the implantation site. Herein, the important aspects of strontium-enriched calcium phosphate bioceramics (Sr-CaPs), and how Sr-CaPs affect the osteogenic microenvironment, are described.

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“…The aim of the present study was to take advantage of the therapeutic agent Sr, a main effective element in the well-known anti-osteoporosis drug strontium ranelate, to incorporate Sr into MSCs to evaluate its feasibility in osteoporotic animal models. 9,17 Sr serves as an essential trace element in the human skeleton. Excessive Sr may lead to cytotoxicity to human organs or bioactivity, making control of the release rate of Sr vital with regard to bone tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Study of Sr–Ca–Si-based scaffolds for bone regeneration in osteoporotic models

Wang

Jiang

et al. 2020

Int J Oral Sci

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Bone tissue engineering has emerged as a promising alternative therapy for patients who suffer bone fractures or defects caused by trauma, congenital diseases or tumours. However, the reconstruction of bone defects combined with osteoporosis remains a great challenge for clinicians and researchers. Based on our previous study, Ca–Si-based bioceramics (MSCs) showed enhanced bone formation capabilities under normal conditions, and strontium was demonstrated to be therapeutic in promoting bone quality in osteoporosis patients. Therefore, in the present study, we attempted to enlarge the application range of MSCs with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes. In vitro readout suggested that Sr-incorporated MSC scaffolds could enhance the expression level of osteogenic and angiogenic markers of osteoporotic bone mesenchymal stem cells (OVX BMSCs). Animal experiments showed a larger new bone area; in particular, there was a tendency for blood vessel formation to be enhanced in the Sr-MSC scaffold group, showing its positive osteogenic capacity in bone regeneration. This study systematically illustrated the effective delivery of a low-cost therapeutic Sr agent in an osteoporotic model and provided new insight into the treatment of bone defects in osteoporosis patients.

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Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications

Abstract: This review brings up to date the state of the art of strontium and zinc based regenerative therapies, both having a promoting effect on tissue formation and a role inhibiting resorption in musculoskeletal disorders.

Cited by 85 publications

References 108 publications

In Vivo Performance of Hierarchical HRP-Crosslinked Silk Fibroin/β-TCP Scaffolds for Osteochondral Tissue Regeneration

In Vivo Performance of Hierarchical HRP-Crosslinked Silk Fibroin/β-TCP Scaffolds for Osteochondral Tissue Regeneration

Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics

Study of Sr–Ca–Si-based scaffolds for bone regeneration in osteoporotic models

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