Bibliometric Analysis of Global Research Productivity on Vitamin D and Bone Metabolism (2001–2020): Learn from the Past to Plan Future

Malik, Ahmad Azam; Baig, Mukhtiar; Butt, Nadeem Shafique; Imran, Muhammad; Alzahrani, Sami H.; Gazzaz, Zohair Jamil

doi:10.3390/nu14030542

Cited by 13 publications

(18 citation statements)

References 54 publications

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“…This also indirectly reflected the overall favorable development of research in this field. Our results are consistent with previous studies ( 17 , 20 ). Their findings suggested that in recent years, the research hotspot for vitamin D has changed significantly from bone metabolism to other fields, such as neuroscience, cardiovascular diseases, cancer, as well as immune-related diseases.…”

Section: Discussionsupporting

confidence: 94%

“…These data indicate that the influence of Chinese academics and research institutions in this field is relatively limited compared to that of developed Western countries. The lack of impact of Chinese scholars may be related to the weak international collaboration ( 17 ). The same situation is present for India.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in recent years, bibliometrics has been widely applied in the field of medical science, and related studies are rapidly increasing ( 15 ). At present, there are few bibliometric studies on vitamin D. Most of these articles were about vitamin D on bone metabolism or COVID-19 ( 16 , 17 ). Our previous study analyzed the dynamics and trends of vitamin D research in the field of infections ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

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Visual analysis of the research trend and status on the association between vitamin D and immunity: From 2012 to 2021

Luo

Deng

2022

Front. Nutr.

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ObjectiveWe conducted this study to visualize hot spots and trends in the correlation between vitamin D and immunity over the past decade with bibliometric analysis.MethodsWe collected relevant articles in the Web of Science Core Collection from 2012 to 2021 as the data source, and then used CiteSpace software to perform the data analysis. Some graphics were done with Graphpad software.ResultsA total of 1,656 articles were retrieved, with an average citation count of 25.2 times. The United States (439 articles, 26.51%) has the top number of published articles, followed by China (164 articles, 9.90%), England (135 articles, 8.15%), Italy (114 articles, 6.88%), and India (82 articles, 4.95%). The most literature is found in areas of Immunology (337 articles, 20.35%) and Biochemistry Molecular Biology (179 articles, 10.81%). In terms of institutions, the top five institutions with the highest number of publications all belong to Europe. Among them, the League of European Research Universities (LERU) (121, 7.31%) has a greater proportion of output articles. The United States Department of Health Human Services (225, 13.59%) and National Institutes of Health United States (223, 13.47%) funded most articles. The leading five authors with the largest number of publications were Hewison M (19, 1.15%), Bergman P (14, 0.85%), Agerberth B (13, 0.76%), Carlberg C (12, 0.73%), and White JH (12, 0.73%). The top five keywords with the highest co-occurrence frequency are “vitamin d” (367), “d deficiency” (217), “expression” (195), “association” (151), and “d receptor” (132). Among the 17 keyword clusters, the largest cluster is #0 “diet.” Despite cluster #13 “covid-19,” most of the clusters were conducted the studies before 2012.ConclusionThe overall development of research in this field is promising. Western developed countries made outstanding contributions in this area and still take the leading role. But the participation of developing and low-income countries is also impressive. The potential therapeutic effects of vitamin D in immune-related diseases have been noted, especially in multiple sclerosis, COVID-19, etc. This is also the focus and frontier of current research. However, there is still no consensus conclusion in this field. Further research is needed in the future.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Visual analysis of the research trend and status on the association between vitamin D and immunity: From 2012 to 2021

Luo

Deng

2022

Front. Nutr.

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“…Vitamin D 3 (cholecalciferol) is a bioactive substance formed from cholesterol in the human body, and it can also be obtained from food, especially cod liver and other types of oily fish [6]. In the body, cholecalciferol is converted into a hormonally active form -calcitriol (1α,25(OH) 2 D 3 ), and after the formation of a complex with a specific receptor (vitamin D receptor, VDR), it can regulate the expression of more than 1000 genes [7].…”

Section: E X P E R I M E N T a L W O R K S E X P E R I M E N T A L W ...mentioning

confidence: 99%

The impact of vitamin D(3) on bone remodeling in different types of experimental pathology

Mazanova¹,

Makarova²,

Khomenko³

et al. 2022

Ukr.Biochem.J.

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Osteoporosis is a progressive systemic skeletal disease characterized by a decrease in bone density, impairment of its microarchitectonics, and an increased risk of fractures that occur under minimal or no mechanical stress. One of the main causes of osteoporosis is vitamin D deficiency, which leads to disruption of normal bone remodeling. The aim of our study was to analyze the features of the process of bone tissue remodeling by measuring the key biochemical markers of bone formation/resorption in primary and secondary osteoporosis, as well as to investigate the potential corrective effect of vitamin D3 supplementation. The work was conducted on rats with different osteoporosis models: alimentary, dysfunctional and secondary osteoporosis associated with diabetes mellitus. We used ELISA to measure 25(OH)D content in blood serum. Blood serum and bone tissue calcium, and alkaline phosphatase activity were determined with bioassay kits. The content of inorganic phosphate in blood serum and ash was assayed by the Dyce method. It was shown that all the studied pathological conditions were accompanied by vitamin D deficiency, which led to impaired absorption of calcium in the intestine and reabsorption of inorganic phosphates by the kidneys, reducing, as a result, their concentration in the blood serum. Hypocalcemia and hypophosphatemia contributed to the disruption of normal bone remodeling, excessive activation of alkaline phosphatase, and a decrease in the content of calcium and phosphate in bone tissue. Thus, sufficient vitamin D bioavailability was confirmed to be critical for effective bone remodeling in primary and secondary osteoporosis. Keywords: bone remodelin, osteoporosis, type 1 diabetes mellitus, vitamin D

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“…Bibliometric analysis is the timely and comprehensive review of publications during a specific period by analyzing their parameters, such as the number of publications, authors, countries and regions, references, keywords, and so on, which can provide an exhaustive overview of the intellectual landscape and make researchers cast light on the latest research trends ( 12 ). To our knowledge, no bibliometric study has been reported so far at the global level on hepatic glycolipid metabolism .…”

Section: Introductionmentioning

confidence: 99%

Emerging Trends and Hot Spots in Hepatic Glycolipid Metabolism Research From 2002 to 2021: A Bibliometric Analysis

et al. 2022

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Glycolipid metabolic diseases, including type 2 diabetes, non-alcoholic fatty liver disease, obesity, hypertension, dyslipidemia, and atherosclerosis, which have become a major public health concern worldwide, are mainly triggered by hepatic glycolipid metabolism disorder. Bibliometric analysis has provided a comprehensive review of developments in hepatic glycolipid metabolism research and changes in research hotspots over the past 20 years. The articles regarding hepatic glycolipid metabolism from 2002 to 2021 were identified from the Science Citation Index-Expanded of Web of Science Core Collection. Acquired data were then processed by the CiteSpace software and the Online Analysis Platform of Literature Metrology to analyze trends and predict hot spots in this field. A total of 4,856 articles regarding hepatic glycolipid metabolism published from 2002 to 2021 were selected. The leading country was China. The Chinese Academy of Sciences was the most productive institution. Co-citation cluster labels revealed characteristics of ten main clusters: non-alcoholic fatty liver disease, gut microbiota, adiponectin, fructose, fgf21, fatty acid, liver x receptor, nr4a, obese mice, and bile acids. Keyword bursts analysis indicated that management, non-alcoholic fatty liver disease, and modulation were the newly emerging research hot spots. We described the overall structure of scientific research on hepatic glycolipid metabolism and presented systematic information to other researchers. The current focus on NAFLD and gut microbiota is critical to further study and will help explore effective therapeutic strategy for aberrant glycolipid metabolism in liver.

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Bibliometric Analysis of Global Research Productivity on Vitamin D and Bone Metabolism (2001–2020): Learn from the Past to Plan Future

Cited by 13 publications

References 54 publications

Visual analysis of the research trend and status on the association between vitamin D and immunity: From 2012 to 2021

Visual analysis of the research trend and status on the association between vitamin D and immunity: From 2012 to 2021

The impact of vitamin D(3) on bone remodeling in different types of experimental pathology

Emerging Trends and Hot Spots in Hepatic Glycolipid Metabolism Research From 2002 to 2021: A Bibliometric Analysis

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