Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain

Abstract

Background: Considering the pivotal role of inflammasome/pyroptosis in biological function, we visually analyzed the research hotspots of inflammasome/pyroptosis related to the brain in this work through the method of bibliometrics from the Web of Science (WOS) Core database over the past two decades.Methods: Documents were retrieved from WOS Core Collection on October 16, 2020. The search terms and strategies used for the WOS database are as follow: # 1, “pyroptosis”; # 2, “pyroptotic”; # 3, “inflammasome”; # 4, “pyroptosome”; # 5 “brain”; # 6, “# 1” OR “# 2” OR “# 3” OR “# 4”; # 7, “# 5” AND “# 6”. We selected articles and reviews published in English from 2000 to 2020. Visualization analysis and statistical analysis were performed by VOSviewer 1.6.15 and CiteSpace 5.7. R2.Results: 1,222 documents were selected for analysis. In the approximately 20 years since the pyroptosis was first presented, the publications regarding the inflammasome and pyroptosis in brain were presented since 2005. The number of annual publications increased gradually over a decade, which are involved in this work, and will continue to increase in 2020. The most prolific country was China with 523 documents but the United States was with 16,328 citations. The most influential author was Juan Pablo de Rivero Vaccari with 27 documents who worked at the University of Miami. The bibliometric analysis showed that inflammasome/pyroptosis involved a variety of brain cell types (microglia, astrocyte, neuron, etc.), physiological processes, ER stress, mitochondrial function, oxidative stress, and disease (traumatic brain injuries, stroke, Alzheimer’s disease, and Parkinson’s disease).Conclusion: The research of inflammasome/pyroptosis in brain will continue to be the hotspot. We recommend investigating the mechanism of mitochondrial molecules involved in the complex crosstalk of pyroptosis and regulated cell deaths (RCDs) in brain glial cells, which will facilitate the development of effective therapeutic strategies targeting inflammasome/pyroptosis and large-scale clinical trials. Thus, this study presents the trend and characteristic of inflammasome/pyroptosis in brain, which provided a helpful bibliometric analysis for researchers to further studies.

Mapping Knowledge Structure and Research Frontiers of Ultrasound-Induced Blood-Brain Barrier Opening: A Scientometric Study

“…Co-citation analysis indicates the relationship between items based on the frequency they are cited together, with TLS being calculated to assess the total link strength (Zhao et al, 2018 ; Chen et al, 2021 ). The journal co-citation analysis showed that Ultrasound in Medicine and Biology, Journal of Controlled Release , and Journal of the Acoustical Society of America were the top three journals with the largest TLS.…”

“…This database was chosen for three reasons. First, in contrast to other popular databases such as Google Scholar, PubMed, Scopus, or Embase, WOSCC is the most comprehensive and authoritative one across scientific disciplines (Chen et al, 2020 , 2021 ). Second, it is a typical citation database containing literature abstracts and other relevant data such as citation and research collaboration information, facilitating for scientometric analysis (Yeung et al, 2021 ).…”

“…Terms are located more closely to each other if they often co-occur in the same publications and will be assigned automatically to the one cluster with the same colors, otherwise located further away from each other with different colors. The links between nodes represent the network connections, and the strength of the links can be assessed quantitatively with the indicator of total link strength (TLS), which is the sum of link strengths of the terms over all the other terms (Zhao et al, 2018 ; Chen et al, 2021 ).…”

Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field

“…The WoSCC covers a considerable amount of highquality scientific literature in the biomedical, natural, and social sciences, and it was used as the main data source. It is regarded as one of the most widely accepted and suitable databases for bibliometric analysis of scientific publications (Shi et al, 2020;Wang et al, 2019;Merigó et al, 2019;Chen et al, 2021). In addition, the Scopus database (searched at https:// www.scopus.com/) was also searched to validate the results obtained from the WoSCC and provided as supplementary material.…”

“…Second, we employed two widely used scientometric software tools to conduct the present study in paralle, and could get more comprehensive and reliable analysis results. Third, unlike previous similar bibliometric studies, whose results derive from only one database, two databases (WoSCC and Scopus) were employed in this study, which could provide a comprehensive analysis of ultrasound microbubble research (Merigó et al, 2019;Wang et al, 2019;Shi et al, 2020;Chen et al, 2021).…”