Bicarbonate-buffered ropivacaine-mepivacaine solution for medial caruncle anaesthesia

Guerrier, Gilles; Boutboul, David; Chanat, Cédric; Samama, Charles Marc; Baillard, Christophe

doi:10.1016/j.accpm.2016.09.007

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Moreover, a low extracellular pH can be a pain-inducing stimulus itself 25. In contrast, alkalization can enhance the production of ropivacaine base, thus increasing its lipid solubility, potency, and speed of onset 26. In our preliminary study, a large amount of ropivacaine base was formed in a pH range of 5.5–6.0, resulting in a stable and homogenous suspension.…”

Section: Discussionmentioning

confidence: 77%

Ropivacaine-loaded, hydroxypropyl chitin thermo-sensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in rats

Qiao

Huang

et al. 2022

Reg Anesth Pain Med

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Background and objectiveRopivacaine hydrochloride is a commonly used local anesthetic in clinics. However, local injection or continuous infusion of ropivacaine has been associated with several disadvantages. Accordingly, it is important to develop a new controlled release system for local administration of ropivacaine to achieve a prolong anesthetic effect, improve efficacy, and minimize the side effects.MethodsWe developed injectable hydroxypropyl chitin thermo-sensitive hydrogel (HPCH) combined with hyaluronan (HA), which was used to synthesize a ropivacaine (R)-loaded controlled release system. We then conducted drug release test and cytotoxicity assay in vitro. Importantly, we examined the analgesic effects and biocompatibility of this system in vivo by injecting different concentrations of R-HPCH-HA (7.5, 15, 22.5 mg/mL), ropivacaine hydrochloride (RHCL, 7.5 mg/mL), or saline (all in 0.5 mL) near the sciatic nerve in rats.ResultsR-HPCH-HA induced concentration-dependent thermal-sensory blockade and motor blockade in vivo. In hot plate test, R-HPCH-HA (22.5 mg/mL) induced a significant longer thermal-sensory blockade (17.7±0.7 hours), as compared with RHCL (7.5 mg/mL, 5.7±0.8 hours, n=6/group, p<0.05). It also produced a more prolonged motor blockade (6.8±0.8 hours) than RHCL (3.5±0.8 hours, p<0.05). R-HPCH-HA caused less cytotoxicity than RHCL, as indicated by the higher cell viability in vitro (n=8/group).ConclusionOur findings in a sciatic nerve block model demonstrated that the injectable, ropivacaine-loaded controlled release system effectively prolonged the local analgesic effect in rats without notable side effects.

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Section: Discussionmentioning

confidence: 77%

Ropivacaine-loaded, hydroxypropyl chitin thermo-sensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in rats

Qiao

Huang

et al. 2022

Reg Anesth Pain Med

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“…When a mixture of 1.5% mepivacaine (15 ml) and 0.5% bupivacaine (15 ml) was used to block the brachial plexus under ultrasound guidance, Gadsden J [ 35 ] found that the duration of anaesthesia in the mixed solution group was longer than that of 30 ml 1.5% mepivacaine alone and shorter than that of 30 ml 0.5% bupivacaine alone. Gilles Guerrier et al [ 36 ] used 2% mepivacaine combined with 0.75% ropivacaine for regional anaesthesia in in vitro-retinal surgery. The results of these papers were similar to our research, which indicates that a faster sensory block onset and longer analgesia duration can be obtained by combining mepivacaine and ropivacaine.…”

Section: Discussionmentioning

confidence: 99%

Effect of ropivacaine, mepivacaine or the combination of ropivacaine and mepivacaine for epidural anaesthesia on the postoperative recovery in patients undergoing caesarean section: a randomized, prospective, double-blind study

Wang,

Liao,

et al. 2024

BMC Anesthesiol

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Background Anaesthetic methods and drugs with rapid onset, rapid recovery and better postoperative analgesia are more suitable for rapid recovery in obstetric anaesthesia. We formulated the following hypothesis: a combination of mepivacaine and ropivacaine could provide a longer analgesic effect and have more advantages in terms of rapid-recovery indicators. Methods A total of 180 pregnant women scheduled to undergo elective caesarean sections were randomly assigned to three surgical groups, which received 2% mepivacaine (Group M), 2% mepivacaine + 0.75% ropivacaine (Group MR) (Volume 1:1) or 0.75% ropivacaine (Group R) through an epidural catheter. The situation of postoperative analgesia and other indicators of rapid recovery were recorded. Results One hundred and fifty patients were included in the final analysis. Their demographic data were similar. The visual analogue scale (VAS) scores of Group MR and Group R were lower than Group M at 1 and 2 h after surgery both at rest and with movement (P < 0.05), and the time to first ambulation in Group MR (17.38 ± 2.06 h) and Group M (17.20 ± 2.09 h) was shorter than that in Group R (22.18 ± 1.74 h) (P < 0.05). Conclusion Application of 2% mepivacaine combined with 0.75% ropivacaine for epidural anaesthesia can provide longer postoperative analgesia and earlier ambulation, these effect may be more suitable than that of 2% mepivacaine or 0.75% ropivacaine alone for caesarean section. Trial registration This study was registered at Chinese Clinical Trial Registry (Registration number: ChiCTR 2300078288; date of registration: 04/12/2023).

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Adjuvanzien bei der zahnärztlichen Lokalanästhesie

Thiem

Kämmerer

2021

wissen kompakt

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Bicarbonate-buffered ropivacaine-mepivacaine solution for medial caruncle anaesthesia

Cited by 6 publications

References 13 publications

Ropivacaine-loaded, hydroxypropyl chitin thermo-sensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in rats

Ropivacaine-loaded, hydroxypropyl chitin thermo-sensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in rats

Effect of ropivacaine, mepivacaine or the combination of ropivacaine and mepivacaine for epidural anaesthesia on the postoperative recovery in patients undergoing caesarean section: a randomized, prospective, double-blind study

Adjuvanzien bei der zahnärztlichen Lokalanästhesie

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