Bicolor K-edge spectral photon-counting CT imaging for the diagnosis of thoracic endoleaks: A dynamic phantom study

Cosset, Benoit; Sigovan, Monica; Boccalini, Sara; Farhat, Fadi; Douek, Philippe; Boussel, Loîc

doi:10.1016/j.diii.2022.12.003

Cited by 14 publications

(11 citation statements)

References 35 publications

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“…However, in a clinical context, where K-edge images are to be assessed visually, K-edge images would consist of subtracted images, further improving the visualization of the contrast agent. 6,9,19 The attenuation of the phantom increased with photon energy for both PCCT and EICT. One explanation for this could be the difference in the material PMMA (mass attenuation coefficient) compared to water.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, where we measured actual attenuation levels, no subtraction was performed. However, in a clinical context, where K‐edge images are to be assessed visually, K‐edge images would consist of subtracted images, further improving the visualization of the contrast agent 6,9,19 . The attenuation of the phantom increased with photon energy for both PCCT and EICT.…”

Section: Discussionmentioning

confidence: 99%

“…In this field numerous phantom and animal studies have been performed in preclinical PCCT equipment showing promising results 7,8 . Some benefits of using multiple contrast agents in clinical practice could be higher diagnostic accuracy in differentiating uptake and distribution of the contrast agents 9 . Another benefit would be faster examination times and reduced radiation dose as differentiation of contrast can be made in post‐processing after one single examination.…”

Section: Introductionmentioning

confidence: 99%

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No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner

Baubeta,

Laurin Gadsböll,

Will

et al. 2024

J Applied Clin Med Phys

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PurposeThis study aimed to elucidate whether gadolinium contrast in clinically relevant doses can be used with photon‐counting computed tomography (PCCT) as an alternative contrast agent in clinical applications.Material/methodsA CTDI phantom with 3D printed rods filled with different concentrations of gadolinium and iodine contrast was scanned in a PCCT and an energy‐integrated computed tomography (EICT). Attenuation values at different monoenergetic steps were extracted for each contrast concentration.ResultsFor PCCT, gadolinium reached an attenuation >100 HU (103 HU) at 40 keV with a concentration 5 mmol/L whereas the same level was reached at 50 keV (118 HU) for 10 mmol/L and 90 keV (114 HU) for 25 mmol/L. For iodine, the same level of attenuation was reached at 100 keV (106 HU) with a concentration 8.75 mg I/mL.For EICT the lowest gadolinium contrast concentration needed to reach >100 HU (108 HU) was 10 mmol/L at 50 keV. For 25 mmol/L 100 HU was reached at 100 keV. For iodine contrast 108 HU was reached at 110 keV for 8.75 mg I/mL.ConclusionNo K‐edge potential or difference in attenuation curves between iodine and gadolinium contrast is detected on the first clinical available PCCT. Clinically relevant attenuation levels were barely achieved in this setting with gadolinium concentrations approved for human use. The results of this study suggest that, given current scanning technology, gadolinium is not a clinically useful contrast agent for computed tomography because no K‐edge was detected.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner

Baubeta,

Laurin Gadsböll,

Will

et al. 2024

J Applied Clin Med Phys

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“…This means that the contrast agent can be identified specifically and quantitatively, allowing concomitant specific imaging of K-edge contrast agents like gold and gadolinium and their differentiation from surrounding tissue and non-K-edge contrast agents such as iodine-based agents. 1,5,[64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] This new approach may be an advantage for exploring new approaches such as for performing a biphasic organ CT imaging by providing simultaneously a specific enhancement after a consecutive injection of iodine-and gadolinium-based contrast agents 71 or for performing a molecular CT imaging by monitoring the macrophage burden within the high-risk atherosclerotic plaques. 70 Despite the multiple preclinical studies taking advantage of color K-edge imaging, translation in humans still has to be developed.…”

Section: Color K-edge Imagingmentioning

confidence: 99%

“…Color K-edge imaging places the energy bin boundaries in close proximity to the K-edge energies of elements, defined as the binding energy between the inner electronic layer and the atom. This means that the contrast agent can be identified specifically and quantitatively, allowing concomitant specific imaging of K-edge contrast agents like gold and gadolinium and their differentiation from surrounding tissue and non-K-edge contrast agents such as iodine-based agents 1,5,64–82 . This new approach may be an advantage for exploring new approaches such as for performing a biphasic organ CT imaging by providing simultaneously a specific enhancement after a consecutive injection of iodine- and gadolinium-based contrast agents 71 or for performing a molecular CT imaging by monitoring the macrophage burden within the high-risk atherosclerotic plaques 70 .…”

Section: Clinical Applicationsmentioning

confidence: 99%

First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype

et al. 2023

Self Cite

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Spectral photon-counting computed tomography (SPCCT) technology holds great promise for becoming the next generation of computed tomography (CT) systems. Its technical characteristics have many advantages over conventional CT imaging. For example, SPCCT provides better spatial resolution, greater dose efficiency for ultra-low-dose and low-dose protocols, and tissue contrast superior to that of conventional CT. In addition, SPCCT takes advantage of several known approaches in the field of spectral CT imaging, such as virtual monochromatic imaging and material decomposition imaging. In addition, SPCCT takes advantage of a new approach in this field, known as K-edge imaging, which allows specific and quantitative imaging of a heavy atom-based contrast agent. Hence, the high potential of SPCCT systems supports their ongoing investigation in clinical research settings. In this review, we propose an overview of our clinical research experience of a whole-body SPCCT clinical prototype, to give an insight into the potential benefits for clinical human imaging on image quality, diagnostic confidence, and new approaches in spectral CT imaging.

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CT technology: photon-counting detector computed tomography

Layer¹,

Kravchenko²,

Dell³

et al. 2023

Radiologie

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Hintergrund Die photonenzählende Computertomographie („photon-counting detector computed tomography“, PCD-CT) ist eine Technologie, die viele Einschränkungen der herkömmlichen Detektoren überwindet. Eine direkte Umwandlung der auf den Detektor eintreffenden Photonen in elektrische Signale, verbunden mit einer sensitiveren und präziseren Photonerfassung ermöglicht eine spektrale Auswertung sowie eine potenziell verringerte Strahlenexposition des Patienten. Durch die Kombination von angewandten Energieschwellenwerten und den Verzicht auf Detektorsepten kann elektronisches Rauschen reduziert, die Ortsauflösung erhöht und die Dosiseffizienz gesteigert werden. Bewertung Aktuelle Forschungsarbeiten bestätigen deutlich reduziertes Bildrauschen, reduzierte Strahlendosis, erhöhte Ortsauflösung, verbessertes Jodsignal sowie eine Reduktion von Artefakten. Die spektrale Auswertung potenziert diese Effekte und ermöglicht auch retrospektiv die Errechnung virtuell-monoenergetischer Bilder, virtuell-nativer Bilder oder Jodkarten. Perspektivisch ergibt sich durch die photonenzählende Technologie die Möglichkeit zur Anwendung diverser Kontrastmittel, mit der Aussicht auf einzeitige Mehrphasenbildgebung oder zur Visualisierung bestimmter Stoffwechselprozesse. Bis zum klinischen Einsatz sind hierzu weitere Grundlagenforschung sowie ergänzende Zulassungsprozesse notwendig. Schlussfolgerung Das bisher einzige am Markt verfügbare PCD-CT-Gerät erhielt 2021 die Zulassung. Es bleibt abzuwarten, welche weitere Anwendungen durch Verbesserungen von Hardware und Software möglich werden. Insbesondere für hochauflösende Bildgebung bei detaillierten Fragestellungen und Untersuchungen mit hoher Strahlenbelastung zeigt die Technologie bereits heute eine eindrucksvolle Überlegenheit gegenüber dem vorherigen Technologiestandard.

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Bicolor K-edge spectral photon-counting CT imaging for the diagnosis of thoracic endoleaks: A dynamic phantom study

Cited by 14 publications

References 35 publications

No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner

No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner

First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype

CT technology: photon-counting detector computed tomography

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