Bicycling suppresses abnormal beta synchrony in the Parkinsonian basal ganglia

Storzer, Lena; Butz, Markus; Hirschmann, Jan V.; Abbasi, Omid; Gratkowski, Maciej; Saupe, Dietmar; Vesper, Jan; Dalal, Sarang S.; Schnitzler, Alfons

doi:10.1002/ana.25047

Cited by 50 publications

(69 citation statements)

References 46 publications

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“…Whereas STN‐ or GPi‐DBS reduces FOG in some patients, others suffer from stimulation‐induced freezing, potentially depending on the choice of stimulation parameters . In an interesting recording study comparing STN‐DBS implanted PD patients with and without freezing, Storzer and colleagues discovered that pedaling movements that are (by themselves) not specifically affected by freezing bring out increased power in the low beta band in LFPs in the STN …”

Section: Parkinsonism As Dysfunction Of the Basal Ganglia Thalamocortmentioning

confidence: 99%

“…140 In an interesting recording study comparing STN-DBS implanted PD patients with and without freezing, Storzer and colleagues discovered that pedaling movements that are (by themselves) not specifically affected by freezing bring out increased power in the low beta band in LFPs in the STN. 141 It is believed that freezing can also occur in parkinsonian rodents [142][143][144] and monkeys. 145 The few available studies point to the involvement of components of the mesencephalic locomotor region/pedunculopontine nucleus (PPN).…”

Section: Beyond Akinesia and Bradykinesiamentioning

confidence: 99%

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Changing views of the pathophysiology of Parkinsonism

Wichmann

2019

Movement Disorders

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Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia) have a long history and primarily model the consequences of dopamine loss in the basal ganglia on the function of the basal ganglia/thalamocortical circuit(s). Changes of firing rates of individual nodes within these circuits were originally considered central to parkinsonism. However, this view has now given way to the belief that changes in firing patterns within the basal ganglia and related nuclei are more important, including the emergence of burst discharges, greater synchrony of firing between neighboring neurons, oscillatory activity patterns, and the excessive coupling of oscillatory activities at different frequencies. Primarily focusing on studies obtained in nonhuman primates and human patients with Parkinson's disease, this review summarizes the current state of this field and highlights several emerging areas of research, including studies of the impact of the heterogeneity of external pallidal neurons on parkinsonism, the importance of extrastriatal dopamine loss, parkinsonism‐associated synaptic and morphologic plasticity, and the potential role(s) of the cerebellum and brainstem in the motor dysfunction of Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society

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Section: Parkinsonism As Dysfunction Of the Basal Ganglia Thalamocortmentioning

confidence: 99%

Section: Beyond Akinesia and Bradykinesiamentioning

confidence: 99%

Changing views of the pathophysiology of Parkinsonism

Wichmann

2019

Movement Disorders

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“…This exaggerated pathophysiological beta activity in the basal ganglia has been found associated with bradykinesia and impaired motor function (Brown 2007, Jenkinson & Brown 2011, Oswal et al 2013, Little & Brown 2014. Interestingly, walking and cycling has been found to modulate/normalise beta activity in the subthalamic nucleus (STN) in people with PD (Storzer et al 2017, Hell et al 2018). Walking and cycling was found to decrease STN beta power in people with PD (Storzer et al 2017).…”

Section: Physiology Of Low Beta Oscillationsmentioning

confidence: 99%

“…For instance, at rest in an untreated state (after a medication wash-out period and STN deep brain stimulating (DBS) electrodes switched off), beta power in the STN and beta activity amongst basal ganglia-cortical networks was increased compared to an optimally medicated state and STN DBS switched on (Litvak et al 2011, Cagnan et al 2015, de Hemptinne et al 2015, Kurani et al 2015, Quinn et al 2015. Notably, walking and cycling was found to decrease STN beta power in people with PD (Storzer et al 2017, Hell et al 2018. Moreover, stepping movements have been shown to modulate STN beta power relative to the movement phase (suppressed during contralateral foot lift, Fischer et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Corticomuscular control of walking in older people and people with Parkinson’s disease

Roeder

Boonstra

Kerr

2019

Preprint

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Changes in human gait that result from ageing or neurodegenerative diseases are multifactorial. Here we assess the effects of age and Parkinson’s disease (PD) on corticospinal control in electrophysiological activity recorded during treadmill and overground walking. Electroencephalography (EEG) from 10 electrodes and electromyography (EMG) from two leg muscles were acquired from 22 healthy young, 24 healthy older and 20 adults with PD. Event-related power, corticomuscular coherence (CMC) and inter-trial coherence were assessed for EEG from bilateral sensorimotor cortices and EMG from tibialis anterior muscles during the double support phase of the gait cycle. CMC and EMG power in the low beta band (13-21 Hz) was significantly decreased in older and PD participants compared to young people, but there was no difference between older and PD groups. Older and PD participants spent shorter time in the swing phase than young individuals. These findings indicate age-related changes in the temporal coordination of gait. The decrease in beta CMC suggests reduced cortical input to spinal motor neurons in older people during the double support phase. We also observed multiple changes in electrophysiological measures at high beta and low gamma frequencies during treadmill compared to overground walking, indicating task-dependent differences in corticospinal locomotor control.

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“…Third, the clinical relevance or symptomatic contribution of high‐ versus low‐beta bands is a topic of discussion . Last, alpha/beta‐band activity is influenced by daily life events such as rest tremor, voluntary movements, movement artifacts during gait, different vigilance states and sleep, and aDBS itself, which makes the isolation of disease‐related signals difficult.…”

Section: Adbs Based On Electrophysiological Recordingsmentioning

confidence: 99%

An update on adaptive deep brain stimulation in Parkinson's disease

et al. 2018

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Advancing conventional open‐loop DBS as a therapy for PD is crucial for overcoming important issues such as the delicate balance between beneficial and adverse effects and limited battery longevity that are currently associated with treatment. Closed‐loop or adaptive DBS aims to overcome these limitations by real‐time adjustment of stimulation parameters based on continuous feedback input signals that are representative of the patient's clinical state. The focus of this update is to discuss the most recent developments regarding potential input signals and possible stimulation parameter modulation for adaptive DBS in PD. Potential input signals for adaptive DBS include basal ganglia local field potentials, cortical recordings (electrocorticography), wearable sensors, and eHealth and mHealth devices. Furthermore, adaptive DBS can be applied with different approaches of stimulation parameter modulation, the feasibility of which can be adapted depending on specific PD phenotypes. Implementation of technological developments like machine learning show potential in the design of such approaches; however, energy consumption deserves further attention. Furthermore, we discuss future considerations regarding the clinical implementation of adaptive DBS in PD. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Bicycling suppresses abnormal beta synchrony in the Parkinsonian basal ganglia

Cited by 50 publications

References 46 publications

Changing views of the pathophysiology of Parkinsonism

Changing views of the pathophysiology of Parkinsonism

Corticomuscular control of walking in older people and people with Parkinson’s disease

An update on adaptive deep brain stimulation in Parkinson's disease

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