2017
DOI: 10.1073/pnas.1702913114
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Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation

Abstract: The K + channel KCNQ1 has been proposed as a tumor suppressor in colorectal cancer (CRC). We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their effects on CRC differentiation, proliferation, and invasion. Molecular and pharmacologic approaches were used to determine the influence of KCNQ1 expression on the Wnt/β-catenin signaling and epithelial-to-mesenchymal transition (EMT) in human CRC cell lines of varying stages of differentiation. The expression of KCNQ1… Show more

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Cited by 66 publications
(77 citation statements)
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“…We also find that accuracy scores are generally higher for KCNQ1 and KCNQ3, potentially indicating that they are better classifiers and thus relatively more associated with their respective pathways. This result reinforces previous evidence that associates the expression of KCNQ1 in colorectal cell lines with a direct physical interaction with beta catenin (Rapetti-Mauss et al, 2017), and potentially expands the interaction to involve other KCNQ genes.…”
Section: Resultssupporting
confidence: 90%
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“…We also find that accuracy scores are generally higher for KCNQ1 and KCNQ3, potentially indicating that they are better classifiers and thus relatively more associated with their respective pathways. This result reinforces previous evidence that associates the expression of KCNQ1 in colorectal cell lines with a direct physical interaction with beta catenin (Rapetti-Mauss et al, 2017), and potentially expands the interaction to involve other KCNQ genes.…”
Section: Resultssupporting
confidence: 90%
“…There is preliminary evidence to suggest that KCNQ1 plays a tumor suppressive role in the stomach and colon (Rapetti-Mauss et al, 2017; Than et al, 2014), and hepatocellular carcinoma (Fan et al, 2018), and that KCNQ3 potentially plays a role in oesophageal adenocarcinoma (Frankell et al, 2019). It is of particular interest to study the roles of ion channels in the gastrointestinal tract due to the critical nature of the ionic homeostasis that is required for their varied physiological functions.…”
Section: Introductionmentioning
confidence: 99%
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“…The results presented in this study highlight the relevance of TRPM4 expression in the EMT regulation and its consequences on invasion properties of PC3 cells. Also, supports previous works showing altered expression of several ion channels in cancer cells and its effect on the EMT induction or reversion (Fortunato, 2017;Lai et al, 2013;Rapetti-Mauss et al, 2017;Restrepo-Angulo, Sánchez-Torres, & Camacho, 2011). Interestingly, the Ca 2+ permeable TRPM7 channel was described as a partial regulator of the EMT process through the EGF-induced expression of the mesenchymal marker vimentin in the breast cancer cell MDA-MB-468 (Davis et al, 2013).…”
Section: Discussionsupporting
confidence: 90%
“…Indeed, TMEM16A has been shown to interact with the ezrin-radixin-moesin network (Perez-Cornejo et al 2012) and with TrpV1 (Takayama et al 2015), TrpC6 (Wang et al 2016) and the IP3 receptor (Jin et al 2013) for coupled GPCR and ion channel signaling. Interestingly, the key signaling molecule -catenin involved in numerous cancers was also found recently to associate with the ion channels KCNQ1 (Rapetti-Mauss et al 2017) and BKCa (Bian et al 2011) to modulate Wnt signaling.…”
Section: Discussionmentioning
confidence: 95%