Bifidobacteria and Their Health-Promoting Effects

Hidalgo-Cantabrana, Claudio; Delgado, Susana; Ruíz, Lorena; Ruas‐Madiedo, Patricia; Sánchez, Borja; Margollés, Abelardo

doi:10.1128/9781555819705.ch3

Cited by 78 publications

(80 citation statements)

References 160 publications

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“…Although Bifidobacterium was depleted in AIH independently of diet, higher average protein intake may favour its growth, as has been recently demonstrated for an amino acid mixture in an animal model 25 . Bifidobacterium species are considered key regulators of gut homeostasis and may exert several health‐promoting effects 26 . In infants, lower intestinal levels of bifidobacteria were prospectively linked to the incidence of immunologic disorders, pointing towards a critical role of enteric bifidobacteria for immune regulation in humans 27,28 .…”

Section: Discussionmentioning

confidence: 99%

A disease‐specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis

Liwinski

Casar

Ruehlemann

et al. 2020

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

A disease‐specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis

Liwinski

Casar

Ruehlemann

et al. 2020

Aliment Pharmacol Ther

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“…29 Firmicutes and Bacteroidetes constitute the most abundant phyla in the adult's gut and intestine, and Actinobacteria is predominant in the gut of breastfed infants. 30 Bifidobacterium is the most abundant bacteria in Actinobacteria and considered to be probiotic microorganisms. Here we quote the definition of microbiota and microbiome by Samantha and Whiteside.…”

Section: Introduction Of Gut Microbiomementioning

confidence: 99%

Gut microbiome in type 1 diabetes: A comprehensive review

Zheng

Zhang

2018

Diabetes Metabolism Res

175

141

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SummaryType 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome‐wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D has been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D‐triggering factors, especially environmental factors. In this review, we summarize the current aetiological and mechanism studies of gut microbiome in T1D. A better understanding of the role of gut microbiome in T1D may provide us with powerful prognostic and therapeutic tools in the near future.

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“…Hepatic failure caused by D-GalN is similar to fulminant viral hepatitis in human (19,20), and D-GalN-induced acute liver failure models are well characterized and widely used. B. longum is often found in the human gastrointestinal tract and exerts probiotic effects (10). Most studies on B. longum R0175 have focused on its psychobiotic effects on mental illness (15-17).…”

Section: Discussionmentioning

confidence: 99%

“…Within the genus Bifidobacterium, Bifidobacterium longum is the most abundant species (7). A wide variety of beneficial attributes have been described for this organism, such as activation of immunity (8), participation in metabolism (9), and inhibition of intestinal pathogens (10). B. longum is commonly applied as a probiotic and has been found to hold great promise for protection against liver injury (11)(12)(13)(14).…”

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confidence: 99%

Bifidobacterium longum R0175 Protects Rats against d -Galactosamine-Induced Acute Liver Failure

Wang

Ren

et al. 2020

mSphere

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Acute liver failure is a severe liver disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of B. longum R0175 against acute liver failure caused by d-galactosamine (d-GalN) in rats and further tested the hypothesis that B. longum R0175 exerted liver-protective effects by affecting the intestinal microbiota and fecal metabolites and by inhibiting inflammation. We found that oral gavage of B. longum R0175 markedly reduced the severity of liver injury in d-GalN-treated rats, as evidenced by decreased serum levels of aspartate aminotransferase (AST) and total bile acids (TBAs) (P < 0.05). Moreover, the plasma concentrations of proinflammatory cytokines (interleukin 1β [IL-1β] and tumor necrosis factor-α [TNF-α]) and chemokines (granulocyte-macrophage colony-stimulating factor [GM-CSF], macrophage chemoattractant protein 1 [MCP-1], chemokine [C-X-C motif] ligand 1 [CXCL1], chemokine [C-C motif] ligand 5 [CCL5], and macrophage inflammatory protein-1α [MIP-1α]) were also markedly reduced (P < 0.05). Pretreatment with B. longum R0175 partially reversed the gut microbiota dysbiosis in rats with liver injury by increasing the relative abundances of potentially beneficial bacteria, such as Alloprevotella spp., and decreasing the relative abundances of potentially harmful bacteria, such as Acetatifactor muris, Butyricimonas spp., and Oscillibacter spp. Furthermore, B. longum R0175 administration partially improved the metabolic function of the intestinal microbes, as indicated by the decreased level of lithocholic acid found in the feces. IMPORTANCE Our research investigated the protective and preventive roles of B. longum R0175 in a rat model of acute liver failure. The results illustrated that this probiotic strain exhibited protective effects in rats with acute liver failure. Thus, B. longum R0175 showed clinical application prospects that required further exploration.

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Bifidobacteria and Their Health-Promoting Effects

Cited by 78 publications

References 160 publications

A disease‐specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis

A disease‐specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis

Gut microbiome in type 1 diabetes: A comprehensive review

Bifidobacterium longum R0175 Protects Rats against d -Galactosamine-Induced Acute Liver Failure

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