Bifidobacteria-derived lipoproteins inhibit infection with coxsackievirus B4 in vitro

El-Kfoury, Khalil Antoine; Romond, Marie-Bénédicte; Scuotto, Angelo; Alidjinou, Enagnon Kazali; Dabboussi, Fouad; Hamzé, Monzer; Sané, Famara; Hober, Didier

doi:10.1016/j.ijantimicag.2017.03.010

Cited by 11 publications

(11 citation statements)

References 28 publications

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“…Further investigation revealed that the compound was lipoprotein A, which combined with a viral capsid protein, the coxsackievirus and adenovirus receptor. Interestingly, the protective effect was observed when bifidobacteria were pre-incubated with the virus, but not with HEp-2 cells [ 24 ]. Similar results were obtained in a study in which the anti-rotaviral activity of bifidobacteria was evaluated in MA104 cells.…”

Section: Antimicrobial Effectsmentioning

confidence: 99%

Antimicrobial and Immunomodulatory Effects of Bifidobacterium Strains: A Review

Lim

Shin

2020

J. Microbiol. Biotechnol.

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Bifidobacterium strains can provide several health benefits, such as antimicrobial and immunomodulatory effects. Some strains inhibit growth or cell adhesion of pathogenic bacteria, including multidrug-resistant bacteria, and their antibacterial activity can be intensified when combined with certain antibiotics. In addition, some strains of bifidobacteria reduce viral infectivity, leading to less epithelial damage of intestinal tissue, lowering the virus shedding titer, and controlling the release of antiviral substances. Furthermore, bifidobacteria can modulate the immune system by increasing immunoglobulins, and inducing or reducing pro- or antiinflammatory cytokines, respectively. In particular, these anti-inflammatory effects are helpful in the treatment of patients who are already suffering from infection or inflammatory diseases. This review summarizes the antimicrobial effects and mechanisms, and immunomodulatory effects of Bifidobacterium strains, suggesting the potential of bifidobacteria as an alternative or complementary treatment option.

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Section: Antimicrobial Effectsmentioning

confidence: 99%

Antimicrobial and Immunomodulatory Effects of Bifidobacterium Strains: A Review

Lim

Shin

2020

J. Microbiol. Biotechnol.

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“…At the present stage, a new direction in the treatment and prevention of viral infections is associated with the use of probiotic bacteria strains of Lactobacillus and Bifidobacterium genera. Research and clinical trials are currently being conducted in the world that are devoted to them [ 24 ]. It has been shown that probiotic bacteria are capable of producing an antiviral effect by stimulating the general immune response.…”

Section: Discussionmentioning

confidence: 99%

“…As for bacteria of Bifidobacterium genus, the scientific literature describes the assumptive mechanisms of their antiviral action—a stimulation of the macroorganism immune response, a production of organic acids, ethanol, exopolysaccharides, and also cell wall secreted lipoproteins (LpAs), which are capable of obstructing the interaction of viral particles with human mucous membrane receptors and thereby preventing the infection progression [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to present knowledge, the representatives of B. adolescentis , B. longum , and B. breve species show activity against viruses, and it has been shown that this is a strain-specific feature [ 24 , 26 , 32 ]. According to data obtained from experimental studies conducted in France, Korea, and Colombia in 2015-2017, the representatives of B. longum species showed pronounced antiviral activity against human entero- and rotavirus [ 24 , 26 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Genome Features and In Vitro Activity against Influenza A and SARS‐CoV‐2 Viruses of Six Probiotic Strains

Соловьева

Ilyicheva

Marchenko

et al. 2021

BioMed Research International

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Purpose. The aim of this work was to analyze the complete genome of probiotic bacteria Lactobacillus plantarum 8 RA 3, Lactobacillus fermentum 90 TC-4, Lactobacillus fermentum 39, Bifidobacterium bifidum 791, Bifidobacterium bifidum 1, and Bifidobacterium longum 379 and to test their activity against influenza A and SARS-CoV-2 viruses. Methods. To confirm the taxonomic affiliation of the bacterial strains, MALDI TOF mass spectrometry and biochemical test systems were used. Whole genome sequencing was performed on the Illumina Inc. MiSeq platform. To determine the antiviral activity, A/Lipetsk/1V/2018 (H1N1 pdm09) (EPI_ISL_332798) and A/common gull/Saratov/1676/2018 (H5N6) (EPI_ISL_336925) influenza viruses and SARS-CoV-2 virus strain Australia/VIC01/2020 (GenBank: MT007544.1) were used. Results. All studied probiotic bacteria are nonpathogenic for humans and do not contain the determinants of transmission-type antibiotic resistance and integrated plasmids. Resistance to antibiotics of different classes is explained by the presence of molecular efflux pumps of the MatE and MFS families. Cultures of L. fermentum 90 TC 4, L. plantarum 8 RA 3, and B. bifidum 791 showed a pronounced activity against influenza A viruses in MDCK cells. Activity against the SARS-CoV-2 virus was demonstrated only by the L. fermentum 90 TC 4 strain in VERO cells. Conclusions. The studied probiotic bacteria are safe, have antiviral activity, and are of great importance for the prevention of diseases caused by respiratory viruses that can also infect the human intestine.

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“…Surface bacterial polysaccharides, such as peptidoglycan and LPS, have been shown to promote virion stability and receptor engagement to increase poliovirus and reovirus infectivity in mice (170). Certain Bifidobacteria and Lactobacillus species have even exhibited an inhibitory potential of CVB4 in vitro (175,176). Additionally, depleting microbiota through use of antibiotics is able to reduce rotavirus infection by promoting virus-specific humoral responses (177).…”

Section: Intestinal Commensal Bacteria Can Influence Virus Outcomesmentioning

confidence: 99%

Virus Infection Is an Instigator of Intestinal Dysbiosis Leading to Type 1 Diabetes

Morse

Horwitz

2021

Front. Immunol.

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In addition to genetic predisposition, environmental determinants contribute to a complex etiology leading to onset of type 1 diabetes (T1D). Multiple studies have established the gut as an important site for immune modulation that can directly impact development of autoreactive cell populations against pancreatic self-antigens. Significant efforts have been made to unravel how changes in the microbiome function as a contributor to autoimmune responses and can serve as a biomarker for diabetes development. Large-scale longitudinal studies reveal that common environmental exposures precede diabetes pathology. Virus infections, particularly those associated with the gut, have been prominently identified as risk factors for T1D development. Evidence suggests recent-onset T1D patients experience pre-existing subclinical enteropathy and dysbiosis leading up to development of diabetes. The start of these dysbiotic events coincide with detection of virus infections. Thus viral infection may be a contributing driver for microbiome dysbiosis and disruption of intestinal homeostasis prior to T1D onset. Ultimately, understanding the cross-talk between viral infection, the microbiome, and the immune system is key for the development of preventative measures against T1D.

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Bifidobacteria-derived lipoproteins inhibit infection with coxsackievirus B4 in vitro

Cited by 11 publications

References 28 publications

Antimicrobial and Immunomodulatory Effects of Bifidobacterium Strains: A Review

Antimicrobial and Immunomodulatory Effects of Bifidobacterium Strains: A Review

Genome Features and In Vitro Activity against Influenza A and SARS‐CoV‐2 Viruses of Six Probiotic Strains

Virus Infection Is an Instigator of Intestinal Dysbiosis Leading to Type 1 Diabetes

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