Bifidobacterium lactis inhibits NF-κB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice

Abstract

Our data demonstrate that B. lactis inhibits NF-kappaB and NF-kappaB-regulated genes in IEC and prevents acute colitis and CAC in mice. These results suggest that B. lactis could be a potential preventive agent for CAC as well as a therapeutic agent for inflammatory bowel disease.

Anti-Inflammatory Properties of Streptococcus salivarius, a Commensal Bacterium of the Oral Cavity and Digestive Tract

“…These NF-B or cytokine modulation capacities established in vitro have been correlated with anti-inflammatory effects in vivo. Indeed, daily oral administration of specific strains attenuated inflammation in mice, as shown using experimental models of colitis induced by trinitrobenzene sulfonic acid (TNBS) or dextran sodium sulfate (DSS) (7)(8)(9)(10)(11). Strains able to inhibit intestinal inflammation in these models would likely be good candidates to be used as probiotics against intestinal inflammation.…”

Inhibition of the NF-κB Pathway in Human Intestinal Epithelial Cells by Commensal Streptococcus salivarius

“…Lactobacillus and Bifidobacterium species have been shown to reduce inflammatory responses, including NF-B activation and interleukin-8 (IL-8) production, in various models of intestinal epithelial cells (2,16,28). Interestingly, the immunomodulation capacities of commensal species from the intestinal microbiota established on IECs are correlated with anti-inflammatory effects in vivo (6,9,12,13,25,29). Although close contact between live commensal bacteria and eukaryotic cells leads to many biological activities, some secreted bacterial factors have been characterized as responsible for anti-inflammatory effect (8,17).…”

Secreted Factors from Bifidobacterium animalis subsp. lactis Inhibit NF-κB-Mediated Interleukin-8 Gene Expression in Caco-2 Cells

“…Interestingly, recent investigations have suggested that B. animalis subsp. lactis has potent anti-inflammatory effects (10,13). Although a large number of clinical and experimental studies of probiotics have been performed, neither the mechanisms of action nor the true characteristics of probiotic anti-inflammatory molecules are well understood.…”

“…There have been several in vitro investigations that provide some information about the anti-inflammatory mechanisms of probiotics. Kim and colleagues (13) demonstrated that B. animalis subsp. lactis inhibits NF-B and NF-B-regulated genes in IECs and prevents acute colitis in mice.…”