Bifunctional effects of fucoidan on the expression of inducible nitric oxide synthase

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

“…39) iNOS is also known to involve an inflammatory action by producing a large amount of nitric oxide (NO). 41,42) We therefore investigated whether fucoidan would have an anti-inflammatory effect on DMNinduced liver fibrosis. As expected, fucoidan decreased the inflammation mediators, TNF-, IFN-, IL-1, and iNOS, in rats with DMN-induced liver fibrosis.…”

In vivoanti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algaeLobophora variegata

“…Further, it was shown that a fucoidan extracted from the brown marine algae Fucus vesiculosus Linn. (Fucaceae), commonly known as bladderwrack, presents antithrombotic, anti-complement, and antiproliferative effects in smooth muscle cells (Yang et al, 2006). Later, a heterofucan from the brown seaweed of L. variegata J.V.…”

Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect

“…We observed a significant reduction in nitric oxide (Machiavell et al, 2007) production in the presence of high fucan concentrations (above 375 µg/mL). However, we found a bifunctional effect (Yang et al, 2006;Di Rosa et al, 1996), given that low fucan concentrations Like heparin, fucoidans have been shown to affect many biological activities, such as inflammation, cell proliferation and adhesion, viral infection, and fertilization (Linnemann et al, 2000). However, relatively few studies have interpreted the biological activity of fucoidans in terms of molecular structure (Xie et al, 2000).…”