Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: Synthesis and in vitro biological evaluation as antimicrobial and anticancer agents

Chitosan-MgO Nanocomposite: One Pot Preparation and Its Utility as an Ecofriendly Biocatalyst in the Synthesis of Thiazoles and [1,3,4]thiadiazoles

“…Also, the sulfonamide group (SO 2 NH) showed asymmetric and symmetric stretching signals at υ = 1336–1379 cm −1 and 1136–1161 cm −1 , respectively [22]. In 1 H NMR spectra two methyl groups bordering to hydrazone moiety (CH 3 –C=N–NH) [23] and a thiazole ring [24] were observed as singlet signals at δ = 2.35–2.43 and 2.43–2.59 ppm, respectively, while the NH proton of the sulfonamide group [22] was resonated at δ = 10.43–10.92 ppm.…”

Synthesis, reactions, and biological activity of some triazine derivatives containing sulfa drug moieties

“…Impairment of drug efficacy leads to prolonged therapy and even high mortality rates, particularly, in the case of epidemic disieses and cancer metastasis [1]. Mutant bacteria are stimulated to excrete β lactamases that are able to detoxify β lactam antibiotics.…”

“…4 [({[3 Mercapto 5 oxo 6 [2 (2 thienyl)vinyl] 1,2,4 triazin 4(5H) yl]imino}methyl)amino] benzenesulfonamide turned out to be a powerful antibacterial agent, while all the compounds prepared were inactive against fungal spe cies tested. 4 {[({8 Cyano 4 oxo 3 [2 (2 thienyl)vinyl] 4H,8H [1,2,4]triazino[3,4 b] [1,3,4]thiadiazin 7 yl}amino)(ethoxy)methyl]amino}benzenesulfonamide displayed in vitro promising cytotoxicity against Ehrlich ascites carcinoma cell line with concurrent attenuation of malonodinitrile and it was unique among other compounds being unable to increase glutathione S transferase and reduced glutathione S transferase activities. This compound exhibited also good antioxidant properties that together with its cytotoxicity nom inated it for further investigation in cancer research.…”

2-(3′-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities

“…10,11,12 Thiazole nucleus is also an essential part of all the available penicillins. 13 Among the thiazoles, substituted thiazolecarboxamides exhibited encouraging antibacterial and anticancer activities.…”

“…Most of synthesized analogues were found to be active against various bacterial strains and malignant cells. 15 Hofle and co-workers isolated peptides namely Tubulysins A and D ( 9 ) from the myxobacteria Archangium gephyra and Angiococcus disciformis, respectively, 16,17 were found to display a broad range of anticancer activity. 18 In 2012, Huang and co-worker identified 2-aryl- N -(2-(piperazin-1-yl)phenyl)-thiazole-4-carboxamide (ALIS hit 10 ), as a potent CHK1 inhibitor.…”