2015
DOI: 10.1134/s1068162015040032
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Synthesis, reactions, and biological activity of some triazine derivatives containing sulfa drug moieties

Abstract: Thienyl-triazine-sulphonamide conjugates were prepared from their precursor amines using triethyl orthoformate or ethyl chloroformate as cross coupling reagents. The progress of these reactions was investigated by spectral (IR, NMR, MS) and microanalytical techniques. The synthesized compounds were in vitro screened for antibacterial, antifungal, antioxidant, and anticancer activity. 4-[({[3-Mercapto-5-oxo-6-[2-(2-thienyl)yinyl]-1,2,4-triazin- 4(5H)-yl]imino}methyl)amino]-benzenesulfonamide turned out to be a … Show more

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Cited by 6 publications
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“…The importance of synthesizing a new heterocyclic compound is strongly bonded with the finding of a new drug, capable of destroying any of the diseases that spread around the world. Herein is a new trial, in continuation of our previous work [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], to synthesize a new compound from folic acid in the hope of getting a new promoting drug.…”
Section: Resultsmentioning
confidence: 97%
“…The importance of synthesizing a new heterocyclic compound is strongly bonded with the finding of a new drug, capable of destroying any of the diseases that spread around the world. Herein is a new trial, in continuation of our previous work [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], to synthesize a new compound from folic acid in the hope of getting a new promoting drug.…”
Section: Resultsmentioning
confidence: 97%