Bifunctional superparamagnetic–luminescent core–shell–satellite structured microspheres: preparation, characterization, and magnetodisplay application

Li, Chung-Lin; Huang, Bohr–Ran; Chang, Jia-Yaw; Chen, Jem-Kun

doi:10.1039/c5tc00255a

Cited by 22 publications

(10 citation statements)

References 57 publications

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“…They may be composed of a variety of materials including polymers and inorganic solids such as silica, gold, and silver [ 1 ]. In the past year, core-shell nanostructured polymers have attracted much attention because of their various potential applications in catalysis [ 2 ], display technologies [ 3 , 4 ], actuation systems [ 5 , 6 ], biosensors [ 7 , 8 ], and electronics [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Real-Time Packing Behavior of Core-Shell Silica@Poly(N-isopropylacrylamide) Microspheres as Photonic Crystals for Visualizing in Thermal Sensing

Manivannan

Huang

et al. 2016

Polymers

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Abstract:We grafted thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) brushes from monodisperse SiO 2 microspheres through surface-initiated atom transfer radical polymerization (SI ATRP) to generate core-shell structured SiO 2 @PNIPAM microspheres (SPMs). Regular-sized SPMs dispersed in aqueous solution and packed as photonic crystals (PCs) in dry state. Because of the microscale of the SPMs, the packing behavior of the PCs in water can be observed by optical microscopy. By increasing the temperature above the lower critical solution temperature (LCST) of PNIPAM, the reversible swelling and shrinking of the PNIPAM shell resulted in dispersion and precipitation (three-dimensional aggregation) of the SPM in aqueous solution. The SPMs were microdispersed in a water layer to accommodate the aggregation along two dimensions. In the microdispersion, the SPMs are packed as PCs with microscale spacing between SPMs below the LCST. When the temperature is increased above the LCST, the microdispersed PCs exhibited a close-packed arrangement along two dimensions with decreased spacing between SPMs. The change in spacing with increasing temperature above the LCST resulted in a color change from red to blue, which could be observed by the naked eye at an incident angle. Thus, the SPM array could be applied as a visual temperature sensor.

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Section: Introductionmentioning

confidence: 99%

Real-Time Packing Behavior of Core-Shell Silica@Poly(N-isopropylacrylamide) Microspheres as Photonic Crystals for Visualizing in Thermal Sensing

Manivannan

Huang

et al. 2016

Polymers

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“…For example, Duan et al utilized magnetic beads as a solid support for antibody in a novel laser-induced fluorescence immunoassay, and the detection limit obtained for α-fetoprotein was as low as 1.6 pg/ml, which is about three orders of magnitude lower than that of conventional ELISA [9]. The combination of magnetic and fluorescent properties renders simultaneously easy signal readout and low labor consumption, whereas the fluorescence signals tend to be quenched by the magnetic beads [10,11]. The detection sensitivity might be further improved by utilizing some other robust detection signals which are less susceptible to the presence of magnetic beads.…”

Section: Introductionmentioning

confidence: 96%

Magnetic-bead-based sub-femtomolar immunoassay using resonant Raman scattering signals of ZnS nanoparticles

et al. 2016

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Highly sensitive, specific, and selective immunoassays are of great significance for not only clinical diagnostics but also food safety, environmental monitoring, and so on. Enzyme-linked immunosorbent assays and fluorescence-based and electrochemical immunoassays are important intensively investigated immunoassay techniques. However, they might suffer from low sensitivity or false-positive results. In this work, a simple, reliable, and ultrasensitive magnetic-bead-based immunoassay was performed using biofunctionalized ZnS semiconductor nanocrystals as resonant Raman probes. The resonant Raman scattering of ZnS nanocrystals displays evenly spaced multi-phonon resonant Raman lines with narrow bandwidths and has strong resistance to environmental variation due to the nature of the electron-phonon interaction, thus rendering reliable signal readout in the immunoassays. The superparamagnetic Fe3O4 nanoparticles facilitated greatly the separation, purification, and concentration processes. It is beneficial for both reducing the labor intensity and amplifying the detection signals. The immobilization of antibodies on the surface of magnetic beads, the preparation of resonant Raman probes, and the immunological recognition between the antibody and analyte all occurred in the liquid phase, which minimized the diffusion barriers and boundary layer constraints. All these factors contributed to the ultralow detection limit of human IgG, which was determined to be about 0.5 fM (∼0.08 pg/ml). It is nearly the highest sensitivity obtained for IgG detection. This work shall facilitate the design of nanoplatforms for ultrasensitive detections of proteins, DNAs, bacteria, explosives, and so on. Graphical abstract An ultrasensitive magnetic-bead-based immunoassay was performed using multi-phonon resonant Raman lines of ZnS nanoparticles as detection signals.

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“…[30][31][32] On the other hand, fluorescent NPs can act as deep tissue tracking and visualizing agents. 16,[33][34][35][36] Studies involving polymer-encapsulation strategies have presented excellent results for in vitro studies and the imaging of topical tumor grafts, 33,37,38 but so far in vivo experiments performing deep tissue imaging with HNSs have sparsely been reported. 39 The use of such HNSs for in vivo applications is restricted by the spectral range of LNPs used (visible-red), which limits their optical penetration depth into biological tissues.…”

Section: Introductionmentioning

confidence: 98%

“…Recently, great efforts have been made to combine iron oxide NPs (IONPs) with visible/infrared luminescent nanoparticles (LNPs) such as rare earth doped NPs or quantum dots (QDs). IONPs are known as contrast agents for magnetic resonance imaging (MRI) and magnetic heating mediators. − In fact IONPs are already commercially available, and clinical trials are currently performed with IONPs for therapy and magnetic imaging. − However, fluorescent NPs can act as deep tissue tracking and visualizing agents. ,− Studies involving polymer-encapsulation strategies have presented excellent results for in vitro studies and the imaging of topical tumor grafts, ,, but so far in vivo experiments performing deep tissue imaging with HNS have sparsely been reported . The use of such HNS for in vivo applications is restricted by the spectral range of LNPs used (visible–red), which limits their optical penetration depth into biological tissues.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures

Ortgies

Cueva

Rosal

et al. 2016

ACS Appl. Mater. Interfaces

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Breakthroughs in nanotechnology have made it possible to integrate different nanoparticles in one single hybrid nanostructure (HNS), constituting multifunctional nanosized sensors, carriers, and probes with great potential in the life sciences. In addition, such nanostructures could also offer therapeutic capabilities to achieve a wider variety of multifunctionalities. In this work, the encapsulation of both magnetic and infrared emitting nanoparticles into a polymeric matrix leads to a magnetic-fluorescent HNS with multimodal magnetic-fluorescent imaging abilities. The magnetic-fluorescent HNS are capable of simultaneous magnetic resonance imaging and deep tissue infrared fluorescence imaging, overcoming the tissue penetration limits of classical visible-light based optical imaging as reported here in living mice. Additionally, their applicability for magnetic heating in potential hyperthermia treatments is assessed.

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Bifunctional superparamagnetic–luminescent core–shell–satellite structured microspheres: preparation, characterization, and magnetodisplay application

Abstract: Bifunctional superparamagnetic–luminescent core–shell–satellite structured microspheres are prepared by a layer-by-layer assembly between metal cations and thiol groups for magnetodisplay applications.

Cited by 22 publications

References 57 publications

Real-Time Packing Behavior of Core-Shell Silica@Poly(N-isopropylacrylamide) Microspheres as Photonic Crystals for Visualizing in Thermal Sensing

Real-Time Packing Behavior of Core-Shell Silica@Poly(N-isopropylacrylamide) Microspheres as Photonic Crystals for Visualizing in Thermal Sensing

Magnetic-bead-based sub-femtomolar immunoassay using resonant Raman scattering signals of ZnS nanoparticles

In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures

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