Big family of nano- and microscale drug delivery systems ranging from inorganic materials to polymeric and stimuli-responsive carriers as well as drug-conjugates

Ding

Front. Bioeng. Biotechnol.

et al. 2023

Ovarian cancer stands as the fifth most prevalent cancer among women, causing more mortalities than any other disease of the female reproductive system. There are numerous histological subtypes of ovarian cancer, each of which has distinct clinical characteristics, risk factors, cell origins, molecular compositions, and therapeutic options. Typically, it is identified at a late stage, and there is no efficient screening method. Standard therapies for newly diagnosed cancer are cytoreductive surgery and platinum-based chemotherapy. The difficulties of traditional therapeutic procedures encourage researchers to search for other approaches, such as nanotechnology. Due to the unique characteristics of matter at the nanoscale, nanomedicine has emerged as a potent tool for creating novel drug carriers that are more effective and have fewer adverse effects than traditional treatments. Nanocarriers including liposomes, dendrimers, polymer nanoparticles, and polymer micelles have unique properties in surface chemistry, morphology, and mechanism of action that can distinguish between malignant and normal cells, paving the way for targeted drug delivery. In contrast to their non-functionalized counterparts, the development of functionalized nano-formulations with specific ligands permits selective targeting of ovarian cancers and ultimately increases the therapeutic potential. This review focuses on the application of various nanomaterials to the treatment and diagnosis of ovarian cancer, their advantages over conventional treatment methods, and the effective role of controlled drug delivery systems in the therapy of ovarian cancer.

Section: Nanotechnology Approaches In Oc Treatmentmentioning

confidence: 99%

New trends in diagnosing and treating ovarian cancer using nanotechnology

Ding

Front. Bioeng. Biotechnol.

et al. 2023

Polymers for Advanced Techs

“…The polymers that are used for the preparation of DDS should be biocompatible and biodegradable. Polymer grafted DDS which act as nanocarrriers can be made to accumulate at the inflammation sites, tumors and around antigens by fitting targeting mechanisms in the polymer structures itself and after reaching at the desired site, sustained or controlled release of drug can be achieved 54,55 …”

Section: Polymer Grafted Dds Based On Silicamentioning

confidence: 99%

Smart polymer grafted silica based drug delivery systems

Shah

Jadhav

Belekar

et al. 2022

Smart polymers are a special class of polymers, which respond to the various external stimuli by changing their properties. Recent developments in synthetic polymer chemistry have provided the possibility of designing and synthesis of various new stimuli‐responsive polymers. These stimuli‐responsive polymers can be used to prepare smart drug delivery systems (DDS) by grafting them on various nanomaterials. The main aim of this review is to present collective information on various stimuli‐responsive polymers grafted on silica nanoparticles for the preparation of smart DDS. The stimuli covered are pH, temperature, redox, reactive oxygen species (ROS), glucose concentration, enzymes, magnetic field, and so forth. The structures of various stimuli‐responsive polymers are shown with their relevance to the preparation of smart DDS. The crucial roles of macromolecular design and synthesis of smart polymers in the development of stimuli‐responsive DDS are discussed with examples from literature and the challenges that still exist in this area of research are presented.

“…Several drug carriers such as polymer drug conjugates, , polymer protein conjugates, , polymer micelles, , polymeric nanoparticles, and gold nanoparticles , have been used as carriers for a variety of drugs previously. Few drug nanocarriers such as galactosamine- d -α-tocopherol polyethene glycol 1000 succinate-poly(lactide) (Gal-pD-TPGS-PLA/NPs) loaded with DTX have recently been reported with 55% release time in 14 days .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Magnetic Molecularly Imprinted Anticancer Drug Carrier for the Targeted Delivery of Docetaxel

et al. 2022

Molecularly imprinted biodegradable polymers are receiving considerable attention in drug delivery due to their ability of targeted recognition and biocompatibility. This study reports the synthesis of a novel fluorescence-active magnetic molecularly imprinted drug carrier (MIDC) using a glucose-based biodegradable cross-linking agent for the delivery of anticancer drug docetaxel. The magnetic molecularly imprinted polymer (MMIP) was characterized through scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy, and vibrating sample magnetometry (VSM). The MMIP presented a magnetization value of 0.0059 emu g –1 and binding capacity of 72 mg g –1 with docetaxel. In vitro and in vivo studies were performed to observe the effectiveness of the MIDC for drug delivery. The cell viability assay suggested that the MMIP did not present toxic effects on healthy cells. The magnetic property of the MMIP allowed quick identification of the drug carrier at the target site by applying the external magnetic field to mice (after 20 min of loading) and taking X-ray images. The novel MMIP-based drug carrier could thus deliver the drug at the target site without affecting the healthy cells.