Bilateral agenesis of parotid salivary glands, an extremely rare condition: report of a case and review of literature

Al-Talabani, Nazar G.; Gataa, Ibrahim Saeed; Latteef, Saeed A.

doi:10.1016/j.tripleo.2007.10.013

Cited by 14 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The parotid gland appears first, between the fourth and sixth weeks, as solid epithelial placodes in the developing cheeks, whereas the sublingual and [13][14][15][16] Aplasia and hypoplasia of the major salivary glands, and in particular the parotid gland, are rare developmental anomalies reported to occur either in isolation or in association with developmental facial anomalies of the first and second branchial arches, such as absence of other major salivary glands, dysfunction or absence of the lacrimal glands, hemifacial microsomia, cleft lip and palate, mandibular facial dysostoses, and ectodermal dysplasia, and with genetic anomalies. 6,9,10,[17][18][19][20][21][22][23][24][25][26] As in our study, aplasia of the parotid gland was reported in the pediatric and prenatal literature to be associated with trisomy 21. [6][7][8][9][10] Our study showed nonvisualization of the parotid gland as early as the first trimester of gestation.…”

Section: Discussionmentioning

confidence: 62%

First‐Trimester Nonvisualization of the Parotid Gland and Aneuploidy in Fetuses With Increased Nuchal Translucency

Perlman

Sukenik‐Helevy

Odeh³

et al. 2020

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objectives-Aplasia and hypoplasia of the major salivary glands, particularly the parotid glands, were reported to be associated with trisomy 21. This study aimed to evaluate the value of first-trimester nonvisualization of the parotid gland in a high-risk population of fetuses with increased nuchal translucency (NT). Methods-A single-center prospective observational cohort study was conducted. The feasibility of imaging the parotid gland was assessed in 100 sequential cases of routine low-risk NT scans. In a 2-dimensional image in an axial plane at the level of the fetal mandible, the parotid glands appear as bilateral hyperechoic round areas. Cases referred for counseling for an NT measured above the 95th percentile for gestational age were evaluated for visualization of the parotid glands. Prenatal findings were correlated with fetal genetic analysis results. Results-Forty-two cases with increased NT constituted the final study group. Within the group with nonvisualization of the parotid gland, genetic testing revealed 9 cases of trisomy 21, 3 cases of trisomy 18, and 1 case of monosomy X. The sensitivity and specificity of nonvisualization of the parotid gland as a predictor of aneuploidy were 76% and 80%, respectively. The positive likelihood ratio, negative likelihood ratio, and relative risk were 3.82 (95% confidence interval [CI], 1.67-8.74), 0.29 (95% CI, 0.12-0.71), and 4.33 (95% CI, 1.69-11.09; P < .01). The negative predictive value was 95.14%. Conclusions-First-trimester nonvisualization of the parotid gland may constitute a potential method for detection of aneuploid fetuses within a high-risk population.

show abstract

Section: Discussionmentioning

confidence: 62%

First‐Trimester Nonvisualization of the Parotid Gland and Aneuploidy in Fetuses With Increased Nuchal Translucency

Perlman

Sukenik‐Helevy

Odeh³

et al. 2020

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

“…Agenesis of parotid glands may occur alone or in association with anomalies of the submandibular or lacrimal gland, first brachial arch developmental disturbances, or other congenital anomalies [4–7]. The true incidence of agenesis of the parotid gland is difficult to ascertain because the condition is often asymptomatic [8].…”

Section: Introductionmentioning

confidence: 99%

“…The true incidence of agenesis of the parotid gland is difficult to ascertain because the condition is often asymptomatic [8]. Because saliva is mostly produced by other major and minor salivary glands, xerostomia does not occur and the absence of parotid gland is not noticed by the patient in the majority of cases [4]. …”

Section: Introductionmentioning

confidence: 99%

Congenital Unilateral Agenesis of the Parotid Gland: A Case Report and Review of the Literature

Teymoortash

Hoch

2016

Case Reports in Dentistry

View full text Add to dashboard Cite

Congenital unilateral agenesis of the parotid gland is a rare condition with only few cases reported in the literature. A review of 21 cases in the available literature is presented in this article. We report on a further case of a 34-year-old woman with agenesis of the left parotid gland and lipoma of the right cheek. Clinicopathological characteristics of described cases in the literature were discussed.

show abstract

“…1,2 The common tumors of the buccal space are pleomorphic adenoma, adenoid cystic carcinoma, acinic cell carcinoma, and mucoepidermoid carcinoma. 3 We present herein an interesting case of agenesis of the right parotid gland in an elderly woman with a pleomorphic adenoma in the right buccal space, without other congenital or developmental anomalies.…”

Section: Introductionmentioning

confidence: 99%

Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space

Lee

2010

Jpn J Radiol

View full text Add to dashboard Cite

Unilateral agenesis of the parotid gland is a rare condition. Although pleomorphic adenomas are the most common benign glandular tumors of the buccal space, to the author's knowledge unilateral agenesis of the parotid gland associated with pleomorphic adenoma in the ipsilatearal buccal space has not been previously described in the literature. We present here a case of the association of these two conditions.

show abstract

Bilateral agenesis of parotid salivary glands, an extremely rare condition: report of a case and review of literature

Cited by 14 publications

References 11 publications

First‐Trimester Nonvisualization of the Parotid Gland and Aneuploidy in Fetuses With Increased Nuchal Translucency

First‐Trimester Nonvisualization of the Parotid Gland and Aneuploidy in Fetuses With Increased Nuchal Translucency

Congenital Unilateral Agenesis of the Parotid Gland: A Case Report and Review of the Literature

Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space

Contact Info

Product

Resources

About