Bilateral and symmetric C1-C2 dumbbell ganglioneuromas producing severe spinal cord compression

Ugarriza, L F; Cabezudo, J.M.; Ramı́rez, José M.; Lorenzana, Luis; Porras, Luis Fernando Barón

doi:10.1016/s0090-3019(01)00363-9

Cited by 31 publications

(36 citation statements)

References 13 publications

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“…Microscopically, these tumors contain large ganglion cells and show areas with smaller lymphocyte-like cells within a matrix of fibrous stroma and schwann cells. The distinction from malignant tumor is based on the absence of necrosis or presence of any immature ganglion cells7).…”

Section: Discussionmentioning

confidence: 99%

Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

Huang

Liu

Liao

et al. 2017

J Korean Neurosurg Soc

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Ganglioneuroma (GN) is a rare benign tumor of neural crest origin usually found in the abdomen, but may occasionally present at uncommon sites including the cervical, lumbar, or sacral spine. However, GNs of thoracic spine are extremely rare. In this report, we describe a 12-year-old girl with giant GN in the thoracic spine, who underwent successful resection (T1–4 level) of the tumor. Histopathological examination confirmed the diagnosis. GN should be considered in the differential diagnosis of any paraspinal mass. A high index of suspicion and correlation of clinico-radiological findings is necessary in differentiating a large benign tumor from a malignant growth. Complete surgical excision is the treatment of choice; however tumor size and location need to be considered for the surgical approach (one-step or multiple surgeries). Close follow-up after surgery is mandatory.

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Section: Discussionmentioning

confidence: 99%

Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

Huang

Liu

Liao

et al. 2017

J Korean Neurosurg Soc

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“…Ganglioneuromas are rare, benign tumours composed of mature sympathetic ganglion cells that originate from the neural crest, accounting for approximately 1% of spinal and paraspinal tumours 8. They are most commonly seen in the posterior mediastinum and in the retroperitoneum, with a minority of cases occurring in the cervical region 9 10.…”

Section: Discussionmentioning

confidence: 99%

Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Dias¹,

Rosa²,

Rito³

et al. 2017

BMJ Case Reports

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We describe the case of a 71-year-old man with a ganglioneuroma of the retropharyngeal space. The patient presented with a submucosal bulge of the left oropharyngeal wall during follow-up examination of a treated vocal cord carcinoma. CT and MRI revealed a non-specific, well-defined retropharyngeal soft tissue lesion. Positron emission tomography-CT did not show relevant metabolic activity, excluding the hypothesis of metastatic nodal disease. Surgical biopsy of the lesion was compatible with ganglioneuroma. Ganglioneuromas are well-differentiated tumours composed of mature sympathetic ganglion cells that account for approximately 1% of spinal and paraspinal tumours. Peripherally, ganglioneuromas are predominantly found in the posterior mediastinum and retroperitoneal space. Only nine ganglioneuromas of the retropharyngeal space have been reported in the English literature since the early 1980s.

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“…Regarding treatment, surgical decompression should be undertaken as soon as possible when spinal cord compression is present as present case7). Ganglioneuromas are usually encapsulated masses with a firm consistency that complete surgical resection is the best option for solitary ganglioneuroma18). However, in cases of multiple tumor masses and tumors with the risk of damage to neural and vascular structure, it will be appropriate to do subtotal or partial removal of the lesion and relieve the spinal cord compression19).…”

Section: Discussionmentioning

confidence: 99%

Ventrally Located Cervical Dumbbell Ganglioneuroma Producing Spinal Cord Compression

et al. 2013

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Ganglioneuroma is an uncommon benign tumor and arise from neural crest cells or sympathetic and peripheral nerves. A 13-year-old boy was referred to our institute and presented with three-day history of right upper extremity weakness associated with neck pain for nearly one month. Magnetic resonance imaging showed right side dumbbell shaped extramedullary lesion at the C2-3 level extending outside through neural foramen. Paraspinal and posterior neck mass, cafe au lait spot was identified. We performed surgical decompression of the spinal cord by resection of intradural portion mass. Histopathological diagnosis was ganglioneuroma.

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Bilateral and symmetric C1-C2 dumbbell ganglioneuromas producing severe spinal cord compression

Cited by 31 publications

References 13 publications

Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Ventrally Located Cervical Dumbbell Ganglioneuroma Producing Spinal Cord Compression

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