Bilateral anterior granulomatous uveitis associated with cutaneous Rosai-Dorfman disease

Gaviria, Juan Guillermo Hoyos; Johnson, Daniel A.; Kinney, Marsha C.; Proffer, Liana H.; Losi-Sasaki, Jacqueline M.; Kraus, Eric W.

doi:10.1007/s00417-004-0993-9

Cited by 11 publications

(9 citation statements)

References 12 publications

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“…All cases except 2 [8, 14] had extranodal manifestations in addition to ocular findings. Our patient presented with cutaneous involvement, which is cited as the most common extranodal presentation [6, 7, 13, 15, 16]. In this case, the patient initially presented with a rash for which the biopsy was non-diagnostic.…”

Section: Discussionmentioning

confidence: 99%

“…Performing the workup for uveitis resulted in the incidental discovery of the pancreatic mass and mediastinal lymphadenopathy, which led to the diagnosis of RDD. Uveitis has been shown to precede systemic symptoms by months to years in some cases [4, 6, 7, 11, 13, 17]. However, in most cases, a thorough workup including imaging or biopsy was not performed until other systemic manifestations presented.…”

Section: Discussionmentioning

confidence: 99%

“…Uveitis is rarely associated with RDD, and only 13 cases have been reported in the English literature in the past 2 decades (Table 1). Patients most commonly present as chronic recurrent bilateral granulomatous uveitis and overall have a good visual prognosis [6]. Treatment usually entails topical and oral steroids, but radiation, chemotherapy, and surgical excision is used in cases with severe systemic disease.…”

Section: Discussionmentioning

confidence: 99%

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Extranodal Rosai-Dorfman of the Pancreas Presents with Bilateral Granulomatous Anterior Uveitis

2018

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Background/Aims: To report a case of a 65-year-old female who presented with bilateral anterior granulomatous uveitis, which led to the diagnosis of Rosai-Dorfman Disease (RDD) and the discovery of an associated pancreatic mass. Methods: This is a retrospective case report of a single patient. Results: A 65-year-old African American Female received a full workup for bilateral anterior granulomatous uveitis and was found to have a pancreatic mass on imaging. Biopsy of this mass was diagnostic for RDD, a rare proliferative histiocytic disorder, which classically presents with painless cervical lymphadenopathy, leukocytosis, and hypergammaglobulinemia. Conclusion: Although rare, ocular involvement, including eyelid and orbital masses, and anterior uveitis, can herald the development of other systemic manifestations or RDD and can aid in the diagnosis of this systemic disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Extranodal Rosai-Dorfman of the Pancreas Presents with Bilateral Granulomatous Anterior Uveitis

2018

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“…Ophthalmic manifestations can involve the eyelid, orbit, lacrimal gland, and retina. It manifests as granulomatous uveitis, orbital mass, proptosis, or eyelid swellings (3,4). The ophthalmic manifestation may be isolated or can occur in association with cutaneous form of disease or with lymph node involvement.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Rosai‐Dorfman Disease: Presenting as Massive Bilateral Eyelid Swelling

Jat¹,

Panigrahi²,

Srinivasan³

et al. 2009

Pediatric Dermatology

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“…To the best of our knowledge, it was unusual for RDD to be associated with uveitis. 6 , 8 , 11 , 12 Our case is an extranodal RDD with cutaneous nodules and refractory bilateral chronic anterior uveitis complicated with cystoid macular edema (CME) and hyperemic disc, which was successfully treated with posterior subtenon (PST) triamcinolone injection and methotrexate (MTX).…”

Section: Introductionmentioning

confidence: 99%

Rosai–Dorfman disease as chronic bilateral granulomatous anterior uveitis: A case report

Ngathaweesuk,

Jumroendararasame

2024

SAGE Open Medical Case Reports

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Rosai–Dorfman disease is a rare non-Langerhans cell histiocytosis disorder, also known as sinus histiocytosis, with massive lymphadenopathy. Rosai–Dorfman disease is classified into nodal and extranodal diseases. Ocular involvement is one of the common extranodal manifestations; however, uveitis manifestation is infrequent. We reported an interesting Rosai–Dorfman disease patient who presented with chronic bilateral granulomatous anterior uveitis with disc hyperemia and cystoid macular edema. She was a 60-year-old Thai female who had abnormal skin nodules on her back after multiple recurrent chronic anterior uveitis. The diagnosis has been made based on a constellation of the patient’s information, physical examination, and histopathological results. We successfully treated the patient with topical steroids, posterior subtenon triamcinolone 20-mg injection, and methotrexate.

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Bilateral anterior granulomatous uveitis associated with cutaneous Rosai-Dorfman disease

Abstract: Anterior granulomatous uveitis may be the presenting sign of cutaneous RDD. Consultation is necessary for accurate diagnosis.

Cited by 11 publications

References 12 publications

Extranodal Rosai-Dorfman of the Pancreas Presents with Bilateral Granulomatous Anterior Uveitis

Extranodal Rosai-Dorfman of the Pancreas Presents with Bilateral Granulomatous Anterior Uveitis

Cutaneous Rosai‐Dorfman Disease: Presenting as Massive Bilateral Eyelid Swelling

Rosai–Dorfman disease as chronic bilateral granulomatous anterior uveitis: A case report

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