Bilateral hypernephroma with solitary pancreatic metastasis

Abstract

A case of bilateral renal carcinoma with an uncommon solitary metastasis is presented. Therapeutic rationale is discussed.

Renal cell carcinoma to the pancreas in surgical pathology material

“…The primary tumor developed in the right and left kidney almost equally in the cases reported in the literature and in our cases. Bilateral primary tumors giving rise to metastatic disease in the pancreas have been reported in the literature,7, 16, 17, 24, 43, 45, 46, 49 although we did not have any patients with bilateral tumors. The distinction between a metastasis to the contralateral kidney and a second primary tumor is beyond the scope of this discussion.…”

“…Metastatic tumors to the pancreas, excluding those involved with widespread disease or in direct continuity with the pancreas, are rare clinically and are exceedingly difficult to differentiate from a primary pancreatic neoplasm. When metastatic foci to the pancreas clinically manifest as mass lesions, lung, breast, colon, skin (melanoma), and kidney primary tumors are among the metastatic neoplasms that are found most frequently 1–58. Secondary involvement of the pancreas by metastatic renal cell carcinoma (RCC), especially in surgical pathology material, is rare.…”

Metastatic renal cell carcinoma to head of the pancreas successfully treated by left nephrectomy and pancreatoduodenectomy

“…To our knowledge, 27 cases of metastatic renal cell carcinoma to the pancreas in patients who received surgical resection have been reported (Table 1). Six patients underwent nephrectomy and resection of a metastatic lesion simultaneously, and 20 underwent surgical resection after the treatment of the primary renal lesion.…”

Solitary metastasis from renal cell carcinoma presenting as diffuse pancreatic enlargement

“…13 In the medical literature, the interval between diagnosis of the primary tumor and diagnosis of pancreatic metastases varies from synchronous presentation to 17 years. 9,14 Clinical manifestations of pancreatic metastases vary substantially but may include disturbances of exocrine or endocrine function or both. 2,9 Patients with pancreatic metastases experience various gastrointestinal problems, such as gastrointestinal bleeding, abdominal pain, weight loss, and diarrhea.…”