The hepatic arterial injection of human naked plasmid HGF DNA was effective in suppressing liver fibrosis induced in rats by DMN. The mechanisms by which HGF expression attenuated liver fibrosis may include the suppression of hepatic TGF-beta expression and the induction of MMP expression.

Abstract:We describe a patient with renal cell carcinoma with synchronous metastasis to the head of the pancreas who underwent left nephrectomy and pancreatoduodenectomy. The 57-year-old man was referred to us because of jaundice. Computed tomography of the abdomen showed irregular masses in the left kidney and head of the pancreas. Endoscopic retrograde cholangiopancreatography revealed a filling defect at the head of the pancreas. Renal angi0graphy demonstrated the hypervascular nature of the lesion. No other tumor lesions were discovered. The patient underwent left nephrectomy and pancreatoduodenectomy. Postoperative histopathologic examination revealed clear cell-type renal cell carcinoma in both the renal and pancreatic lesions. At follow-up 3 years later, the patient was alive without evidence of recurrent disease. We present a rare case and assess the role of aggressive surgical management for this unusual problem.

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The authors report a case of cervical cellulitis and mediastinitis developing from odontogenic infection.A 52-year-old woman visited our clinic because of dyspnea and pain on swallowing. She was given a diagnosis of cervical cellulitis caused by an odontogenic infection of the lower left second and third molars. We administered antibiotics and extracted the lower left second and third molars. However, the patient' s condition deteriorated, and the inflammation spread to the contralateral side. Four days later, surgical drainage of the left submental and submandibular regions was performed under general anesthesia.Despite this surgical procedure, a postoperative computed tomographic (CT) scan revealed anterosuperior mediastinitis and thrombosis extending from the right subclavian vein to the brachiocephalic vein. Therefore, transcervical mediastinal drainage, thrombolytic therapy, and placement of a vena cava filter were performed.Subsequently, the patient recovered uneventfully.Our experience indicates that it is important to accurately diagnose rapidly developing lesions and to promptly perform surgery when severe odontogenic infection is encountered.

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