Bilateral Iridocorneal Endothelial Syndrome: Case Report and Review of the Literature

Outcomes of Primary Trabeculectomy With Mitomycin-C in Glaucoma Secondary to Iridocorneal Endothelial Syndrome

“…1 ICE syndrome is typically unilateral, but bilateral or subclinical abnormalities in the corneal endothelium of the fellow eye are not uncommon. 2,3 It is a progressive disease, usually presents in early to middle adulthood, and is more common in female than male individuals. 4 The basic pathology lies in the corneal endothelium, which proliferates and migrates across the angle and on to the anterior surface of the iris.…”

Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects

“…We also noted bilateral involvement in 10% of the subjects, of which 8 subjects had two different clinical variants in either eye. Hemady et al [4], and Huna et al [5], have also reported bilateral involvement in ICE syndrome, among which Huna et al [5], have reported two different clinical variants in the same subject. Presentation of two different variants in two eyes could be due to the fact that ICE syndrome is a spectrum and there can be an overlap in the clinical presentation between the two eyes.…”

“…It typically presents as a unilateral condition, but bilateral or subclinical abnormalities in the corneal endothelium of the fellow eye are not uncommon [4, 5]. It usually manifests in the early to middle adulthood and is seen more frequently in females [3, 6].…”

Phenotypic Heterogeneity of Corneal Endothelium in Iridocorneal Endothelial Syndrome by In Vivo Confocal Microscopy

“…[4][5][6]12 Lucas-Glass et al 5 demonstrated that the clinically uninvolved contralateral eyes in patients with ICE syndrome had subclinical endothelial abnormalities as evidenced by a relatively low percentage of hexagonal cells and a relatively high coefficient of variation of cell area. [4][5][6]12 Lucas-Glass et al 5 demonstrated that the clinically uninvolved contralateral eyes in patients with ICE syndrome had subclinical endothelial abnormalities as evidenced by a relatively low percentage of hexagonal cells and a relatively high coefficient of variation of cell area.…”

“…2 The patients may remain asymptomatic or develop visually significant corneal edema, progressive formation of peripheral anterior synechiae (PAS), secondary glaucoma, and iris defects. [4][5][6] In Vivo Confocal Microscopy (IVCM) has become a well-established modality for imaging the endothelial changes in ICE syndrome because it has superior resolution and image contrast as compared with specular microscopy and also is less affected by corneal alterations like edema or mild scarring. 3 Although ICE syndrome has classically been regarded as being unilateral, bilateral disease either manifesting clinically or having subtle changes in the endothelium of the contralateral eye has been reported previously.…”