Bilateral Loculated Pleural Effusion as a Manifestation of Acute Parenteral Organophosphate Intoxication: A Case Report

Tehrani, M MoinAzad; Soltaninejad, Kambiz; Yazdani, Shahin; Nelson, Lewis S.; Shadnia, Shahin

doi:10.1016/j.jemermed.2010.11.028

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Many OPs are implicated in the development of pulmonary injury in both humans and experimental animals (Atiş et al 2002;Nambiar et al 2007;Moin-Azad Tehrani et al 2011;Angelini et al 2013). It is possible that these chemicals are directly affecting the viability of the pulmonary epithelium resulting in pulmonary distress (Angelini et al 2015).…”

Section: Lung Injurymentioning

confidence: 99%

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Badr

2020

Environ Sci Pollut Res

112

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Organophosphorus insecticides toxicity is still considered a major global health problem. Malathion is one of the most commonly used organophosphates nowadays, as being considered to possess relatively low toxicity compared with other organophosphates. However, widespread use may lead to excessive exposure from multiple sources. Mechanisms of MAL toxicity include inhibition of acetylcholinesterase enzyme, change of oxidants/antioxidants balance, DNA damage, and facilitation of apoptotic cell damage. Exposure to malathion has been associated with different toxicities that nearly affect every single organ in our bodies, with CNS toxicity being the most well documented. Malathion toxic effects on liver, kidney, testis, ovaries, lung, pancreas, and blood were also reported. Moreover, malathion was considered as a genotoxic and carcinogenic chemical compound. Evidence exists for adverse effects associated with prenatal and postnatal exposure in both animals and humans. This review summarizes the toxic data available about malathion in mammals and discusses new potential therapeutic modalities, with the aim to highlight the importance of increasing awareness about its potential risk and reevaluation of the allowed daily exposure level.

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Section: Lung Injurymentioning

confidence: 99%

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Badr

2020

Environ Sci Pollut Res

112

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“…Many organophosphorus (OP) chemicals are implicated in the development of pulmonary injury in both humans and experimental animals [1][2][3][4][5][6][7][8][9][10][11][12][13][14] (for review see Angelini et al 15 ). The pesticides, parathion, and malathion as well as their respective metabolites, paraoxon and malaoxon, are easily absorbed through the skin and mucous membranes.…”

Section: Introductionmentioning

confidence: 99%

The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells

et al. 2015

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Organophosphorus (OP) pesticides are known to induce pulmonary toxicity in both humans and experimental animals. To elucidate the mechanism of OP-induced cytotoxicity, we examined the effects of parathion and malathion and their respective metabolites, paraoxon and malaoxon, on primary cultured human large and small airway cells. Exposure to paraoxon and malaoxon produced a dose-dependent increase in cytotoxicity following a 24-hour exposure, while treatment with parathion or malathion produced no effects at clinically relevant concentrations. Exposure to paraoxon-induced caspase activation, but malaoxon failed to induce this response. Since caspases have a major role in the regulation of apoptosis and cell death, we evaluated OP-induced cell death in the presence of a caspase inhibitor. Pharmacological caspase inhibition protected against paraoxon-induced cell death but not malaoxon-induced cell death. These data suggest that caspase activation is a key signaling element in paraoxon-induced cell death, but not malaoxon-induced cellular death in the pulmonary epithelium.

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“…Currently, MA is an extensively used member of organophosphorus (Ops) family (Bogen & Singhal, 2017; Ozsoy et al., 2016) which can cause injury to the lung (Angelini et al., 2013; Atiş et al., 2002; Moin‐Azad Tehrani et al., 2011; Nambiar et al., 2007). Uysal and Karaman (2018) reported that MA exposure could initiate oxidative stress and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Potential of rosmarinic acid to ameliorate toxic effects of diethyl methoxy thio‑phosphoryl thio‑succinate on albino wistar rats’ lung, mast cell infiltration inhibitory pathway

Ahmed

Mona

Abdel-Kareem

et al. 2021

Food Science & Nutrition

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Malathion (MA) is a widely used pesticide in agriculture. It can cause toxicity in different organs of the body. Rosmarinic acid (RO) is found in rosemary extract that can be absorbed through gastrointestinal tract mucosa with potent antioxidant, and anti‐inflammatory potential. The current study is designed to investigate the potential of RO to protect the lung after MA administration. Forty albino rats were allocated equally to four groups. C‐group received corn oil. RO‐group received RO orally. MA‐group received MA. MA‐RO‐group received RO in addition to MA. After three weeks the lungs were dissected for histopathological and biochemical investigations. MA‐group showed manifestations of severe inflammation with inflammatory cells infiltration in the lung. MA‐RO‐group showed limited inflammatory cell infiltration. C‐group and RO‐group appeared with weak anti‐survivin immunoreactivity. MA‐group showed strong positive immunoreactivity. The reactivity was weakly positive in MA‐RO‐group. MA‐group showed a significant decrease in SP‐D gene expression in comparison to the C‐group, in addition, MA‐RO‐group showed a significant increase in SP‐D expression. In conclusion, the current study approves that oral administration of MA causes lung injury as it has inflammatory effects, caused by oxidative stress and reports the potential of RO to protect lung tissue against toxic effects of MA through its anti‐inflammatory, antioxidant, and anti‐apoptotic potential.

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Bilateral Loculated Pleural Effusion as a Manifestation of Acute Parenteral Organophosphate Intoxication: A Case Report

Cited by 4 publications

References 13 publications

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells

Potential of rosmarinic acid to ameliorate toxic effects of diethyl methoxy thio‑phosphoryl thio‑succinate on albino wistar rats’ lung, mast cell infiltration inhibitory pathway

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