Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Badr, Amira M.

doi:10.1007/s11356-020-08937-4

Cited by 111 publications

(57 citation statements)

References 221 publications

(361 reference statements)

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“…Our results revealed that MAL-treatment induced a signi cant increase in the level of IL-β in the testis, kidney, and lung tissues, while blood, liver, kidney, and heart IL-β level reduced. Experimental studies proved that sub-chronic MAL-induced tissue damage resulted in stimulate in ammatory cytokines releasing in hepatocytes, such as IL-1β (Badr 2020). Moreover, Ince et al(2017) reported an increased IL-1 beta expression MAL-induced toxicity rat model.…”

Section: Discussionmentioning

confidence: 97%

Short-Term of Malathion Intoxication on Lipid Peroxidation, Antioxidant Activity, and down-regulation of pro-Inflammatory Cytokines: Organophosphorus Pesticide Toxicity in Rat Model

Sayadi

Kiani

Alipanah

et al. 2021

Preprint

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Malathion (MAL), a kind of organophosphate pesticides (OPs), is one of the oldest phosphoric pesticides, which used for both domestic and commercial agricultural purposes. However, it possesses adverse effects and organ-specific toxicity in relation to the heart, kidney and other vertebrate organs. The exact effects of the short-term toxicity of MAL on lipid peroxidation, antioxidant activity, and pro-inflammatory cytokines is not yet clear enough. We evaluated lipid peroxidation (MDA level), antioxidant activity [superoxide dismutase (SOD) and catalase (CAT)], TNF-alpha, and IL-1 bet in different tissues of MAL-treated Wistar rats, at doses of 50, 100, 200 and 150 mg/kg. After 14 days exposure, CAT and SOD activity, MDA level increased in most tissues. The histopathological results showed that the most sensitive tissues to MAL toxicity were liver, kidney, and heart. Also, in general, increased TNF-alpha measured as inflammatory cytokine compared to untreated rats. IL-1 beta levels showed a dual response to the toxic effects of MAL; increased in testis, kidney and lung tissues and decreased in liver, heart and blood tissues.The present findings reinforce the concept that short-term MAL toxicity can cause tissue damage while enhancing the activity of antioxidant enzymes and reducing cytokine levels.

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Section: Discussionmentioning

confidence: 97%

Short-Term of Malathion Intoxication on Lipid Peroxidation, Antioxidant Activity, and down-regulation of pro-Inflammatory Cytokines: Organophosphorus Pesticide Toxicity in Rat Model

Sayadi

Kiani

Alipanah

et al. 2021

Preprint

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“…Several studies in humans have suggested pesticides, including malathion, are linked to nephrotoxicity [ 30 ]. An El Salvadoran study did not find a relationship between “ever use” of 2,4-D, organophosphates, and pyrethroids and reduced kidney function among sugarcane workers after harvest season based on self-reported exposure [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…While little is known about the nephrotoxic pathological pathways of pesticides with most evidence derived from animal studies [ 29 ], the pathological pathway will depend on the class of toxin involved. Organophosphates have been implicated in nephrotoxic activity in animals via oxidative stress (reduced glutathione metabolism) [ 30 ] and in porcine cell culture via oxidative stress at the tubular level [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010

Wan

Darssan

Karatela

et al. 2021

IJERPH

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Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. We pooled data from four cross-sectional waves of NHANES, with 41,847 participants in total. Exposure to malathion increased the risk of low kidney function (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Increased risk of low kidney function was not found among those exposed to 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12), and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13). Our findings provide evidence of altered kidney function in people exposed to malathion, highlighting the potential of organophosphate pesticides’ role in renal injury.

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“…Several studies in humans have suggested pesticides, including Malathion are linked to nephrotoxicity (Badr 2020). An El Salvadoran study did not nd a relationship between "ever use" of 2,4-D, organophosphates and pyrethroids and reduced kidney function among sugarcane workers after harvest season, based on self-reported exposure (Garcia-Trabanino et al 2015).…”

Section: Pesticide Exposures With Kidney Function Loss and Ckdumentioning

confidence: 99%

Association of pesticides and kidney function among adults in the US population 2001-2010

Wan

Darssan

Karatela

et al. 2021

Preprint

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Background Chronic kidney disease with unknown cause (CKDu) is prevalent in tropical and agricultural communities, however, its aetiology remains unclear. The objective of this study was to examine the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. Methods We pooled data from four cross-sectional waves of NHANES, providing 41,847 participants in total. Sub-population analyses for 2,4-dichlorophenoxyacetic acid (2,4-D), 3,5,6- trichloropyridinol, 3-phenoxybenzoic acid (3-PBA) and Malathion were conducted using. Logistic regression to estimate the odds ratios (ORs) and 95% CIs of the association between log-pesticide levels and kidney function. Results We found that Malathion acid increased the risk of low kidney function among the Malathion sub-population (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Significantly increased risk of low kidney function was not found among the 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12) and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13) subpopulations. Conclusions Our findings provide evidence of altered kidney function in people exposed to Malathion, highlighting the need to focus on Malathion acid as a potential cause of renal injury or chronic kidney disease.

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Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Cited by 111 publications

References 221 publications

Short-Term of Malathion Intoxication on Lipid Peroxidation, Antioxidant Activity, and down-regulation of pro-Inflammatory Cytokines: Organophosphorus Pesticide Toxicity in Rat Model

Short-Term of Malathion Intoxication on Lipid Peroxidation, Antioxidant Activity, and down-regulation of pro-Inflammatory Cytokines: Organophosphorus Pesticide Toxicity in Rat Model

Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010

Association of pesticides and kidney function among adults in the US population 2001-2010

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