Background: Naevus of Ota, also called naevus fusculocoeruleus ophtalmomaxillaris, belongs to the group of dermal melanocytoses. It typically occurs in the Asian population, and it is extremely rare in Caucasians. The management of naevus of Ota has been challenging. Observation: We report a Caucasian patient presenting with a bilateral naevus of Ota which was successfully treated using a Q-Switched (QS) Nd: YAG 1064 laser. We further review the various available therapeutic options as well as the results obtained with various laser types, including the QS Nd: YAG 1064 and 532 nm, the QS ruby 694 nm and the QS alexandrite 755 nm lasers. Conclusion: Based on the remarkable clinical improvement observed in our case and previous reports, Q-Switched lasers currently represent the treatment of choice for the naevus of Ota. Development of picosecond techno logy in laser medicine has opened a new perspective for the treatment of Ota.