Bilateral panophthalmitis in dengue fever

Sriram, Sangeetha; Kavalakatt, Joel Antony; Pereira, Alan de Lima; Murty, Shakuntala

doi:10.4103/1755-6783.159837

Cited by 10 publications

(9 citation statements)

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“…Another report of a unilateral panophthalmitis was reported by Richa Kamal et al who also observed the complication occurring during the critical phase of illness and Bacillus cereus was isolated from the eviscerated sample of the eye 6. Lastly, a case reported by Sriram et al, showed affection of both eyes by dengue panophthalmitis leading to similar outcome 7…”

Section: Discussionmentioning

confidence: 75%

Panophthalmitis in a patient with dengue fever

et al. 2019

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Dengue fever is known for its life-threatening complications of bleeding and capillary leak syndrome. We report an unusual complication of dengue fever causing panophthalmitis, leading to rapidly progressive painful visual loss within days. Later on, the patient developed secondary bacterial infection of the eyeball and developed multiple brain abscesses due to spread of infection from the eyeball. Culture from pus swab of the right eye grew Staphylococcus epidermidis. The patient was promptly treated with broad spectrum antibiotics and after stabilisation, evisceration of the affected eye was done. Supportive therapy in the form of mechanical ventilation in view of poor sensorium, platelet transfusions for thrombocytopenia and guided fluid therapy was also provided. After multiple challenges in the management of the patient, fortunately, the patient survived but we failed to save his right eye. Therefore, it is necessary to carefully examine all vital organs at an early stage to prevent unfortunate outcome.

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Section: Discussionmentioning

confidence: 75%

Panophthalmitis in a patient with dengue fever

et al. 2019

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“…has reported a 25-year-old male with bilateral panophthalmitis in a serology-positive case of dengue fever where they isolated Gram-positive cocci from eye swab, but no growth on culture. [ 9 ] Saranappa and Sowbhagya reported a case of 6-year-old girl with serology-positive dengue who developed unilateral panophthalmitis with no microbiological isolate from ocular sample. [ 8 ] Neither of the cases had any microbiological isolation from the eviscerated sample.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Panophthalmitis is a rare complication, which has been reported in only 2 cases in literature till date. [ 8 9 ] We report the first case of culture-positive unilateral panophthalmitis in a serology-positive patient of dengue hemorrhagic fever.…”

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confidence: 99%

Culture-positive unilateral panophthalmitis in a serology-positive case of dengue hemorrhagic fever

Kamal

Shah

Sharma

et al. 2018

Indian J Ophthalmol

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Dengue fever, a mosquito-borne disease commonly found in the tropics, is one of the most prevalent forms of Flavivirus infection in humans. Symptomatically, it is characterized by fever, arthralgia, headache, and rash. Ophthalmic manifestations can involve both the anterior and posterior segment. Panophthalmitis is rare in dengue hemorrhagic fever, and there is no report of culture-positive panophthalmitis in this setting. Here, we report a case of a serology-positive 33-year-old male patient of dengue hemorrhagic fever who developed sudden onset pain, redness, and proptosis in the right eye. The patient subsequently developed panophthalmitis in his right eye, and Bacillus cereus was isolated from eviscerated sample. This case provides unique insights into pathogenesis of panophthalmitis in dengue and highlights the management options.

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“…[ 9 10 11 12 13 14 15 16 17 18 ] Notably, over the past decade, the disease has manifested in a severe form of ocular and orbital involvement with the scleral melt, necrotizing scleritis, globe rupture, endophthalmitis, and panophthalmitis. [ 19 20 21 22 23 24 25 26 27 ] However, the existing literature is limited to the case report and short case series. In the current communication, we report the presentations and management outcomes of cases with various presentations of severe ocular and adnexal involvement in dengue hemorrhagic fever.…”

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confidence: 99%

Severe ocular and adnexal complications in dengue hemorrhagic fever

Vempuluru

Dave

Murthy

et al. 2021

Indian Journal of Ophthalmology

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Purpose: To describe a series of sight-threatening ocular and adnexal involvement associated with dengue hemorrhagic fever and their treatment options. Methods: Retrospective, interventional, non-comparative case series. Medical records of patients who presented with ocular symptoms attributed to dengue hemorrhagic fever were reviewed. Demography, presenting features, and treatment outcomes were recorded. Outcome measures assessed included globe salvage, vision salvage, and visual improvement. The outcome was deemed as favorable if vision salvage was possible and unfavorable if the vision was lost. Results: Twenty-nine eyes of 23 patients were included. Bilateral ocular involvement was seen in 6 (26%) patients. The mean age was 37.62 ± 18.68 years (range: 14 to 81 years). Coexistent diabetes mellitus and enteric fever were present in three patients. History of blood transfusion was present in nine (40%) and thrombocytopenia in eight (35%) patients at the time of presentation with ocular complaints. Presenting features included endophthalmitis in 11 (38%), panophthalmitis in 10 (35%), orbital cellulitis with panophthalmitis in four (14%), isolated corneal or scleral melt in three (10%), and orbital hemorrhage with panophthalmitis in one (3%) patient. Globe salvage was achieved in 21/29 eyes (72.4%), vision salvage in 6/29 eyes (20.68%), and improvement in visual acuity was noted in 5/29 eyes (17.24%). Logistic regression analysis revealed no significant effect of any clinical-microbiological factors on globe salvage, vision salvage, and visual improvement. However, visual improvement and globe salvage were possible in eyes that underwent early endoscopic vitrectomy. Conclusion: Dengue fever can present with sight-threatening ocular and adnexal inflammation resulting in endophthalmitis and panophthalmitis, orbital cellulitis, corneal and scleral melt, and orbital hemorrhage. Early vitrectomy may improve vision and globe salvage in cases with significant vitritis.

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Bilateral panophthalmitis in dengue fever

Cited by 10 publications

References 0 publications

Panophthalmitis in a patient with dengue fever

Panophthalmitis in a patient with dengue fever

Culture-positive unilateral panophthalmitis in a serology-positive case of dengue hemorrhagic fever

Severe ocular and adnexal complications in dengue hemorrhagic fever

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