Bilateral primary renal lymphoma treated by surgery and chemotherapy

Cupisti, Adamasco; Riccioni, R; Carulli, Giovanni; Paoletti, Sabrina; Tognetti, A; Meola, Mario; Francesca, F.; Barsotti, Giovanni; Petrini, Mario

doi:10.1093/ndt/gfh250

Cited by 30 publications

(35 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The existence of PRL has long been disputed as the kidneys are devoid of lymphatic tissues. Although the actual number of reported PRL cases is questionable secondary to incomplete staging and the presence of extrarenal involvement at the time of diagnosis, an accumulation of new literature in recent years suggests that the entity of PRL does exist [4, 5, 6]. There are several theories surrounding the origin of PRL.…”

Section: Discussionmentioning

confidence: 99%

Primary renal lymphoma: an unusual finding following radical nephrectomy

Rissman

Dagrosa

Pettus

et al. 2017

CNCS

View full text Add to dashboard Cite

Secondary kidney involvement by disseminated non-Hodgkin’s lymphoma (NHL) is quite common and is estimated to approach 30 – 60% in NHL patients. However, primary renal lymphoma is exceedingly rare and estimated to make up less than 1% of all kidney masses. We report a case of primary renal NHL presenting with profound hypercalcemia and renal failure recalcitrant to medical management, ultimately treated with urgent radical nephrectomy. To our knowledge, this is the first report of primary renal lymphoma presenting in this acute fashion.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary renal lymphoma: an unusual finding following radical nephrectomy

Rissman

Dagrosa

Pettus

et al. 2017

CNCS

View full text Add to dashboard Cite

show abstract

“…Its origin is somewhat uncertain. Because the renal parenchyma does not normally contain lymphoid tissue, several mechanisms have been postulated to account for the development of lymphoma in the kidney: The tumor may originate in the lymphatic-rich renal capsule or the perinephric fat and invade the parenchyma, or it can arise from lymphocytes present in areas of chronic inflammation (17,20,21). The tumor is usually a B-cell non-Hodgkin lymphoma and affects patients who are middle aged or older.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Imaging of Renal Lymphoma: Patterns of Disease with Pathologic Correlation

Sheth

Ali²,

Fishman³

2006

RadioGraphics

184

126

View full text Add to dashboard Cite

Extranodal spread of lymphoma often affects the genitourinary system, with the kidneys being the most commonly involved organs. Contrast material-enhanced computed tomography (CT) remains the modality of choice for the detection, diagnosis, staging, and monitoring of renal lymphoma. Magnetic resonance (MR) imaging is particularly useful in patients in whom intravenous administration of iodinated contrast material is contraindicated. Ultrasonography (US), although very valuable for diagnosing lymphoma in the testis or epididymis, is less sensitive than CT and MR imaging for detecting renal lymphoma. Typical imaging findings of renal lymphoma include multiple poorly enhancing or hypoechoic masses, retroperitoneal tumors directly invading the kidneys, bilateral renal enlargement, and perirenal soft-tissue masses. Cystic lesions and tumors predominantly affecting the renal sinus and collecting system are uncommon. Unless the renal lesions manifest in the setting of widespread lymphoma, percutaneous biopsy is indicated to differentiate lymphoma from metastases, hypovascular renal cell carcinoma, uroepithelial carcinoma, or atypical infection, with US routinely being used to guide the procedure. Current immunohistochemical techniques allow accurate diagnosis and characterization of renal lymphoma. Radiologists should be familiar with both typical and atypical manifestations of renal lymphoma and should recommend imaging-guided percutaneous biopsy for diagnostic confirmation to avoid unnecessary nephrectomy.

show abstract

“…Renal lymphomas may be unilateral or bilateral and typically occurs in middle aged to elderly adults. 6,9,10 Clinical presentation as in our cases are nonspecific and includes weight loss, flank pain, hematuria, renal failure, loss of appetite, and malaise. Similar to renal cell carcinomas, lymphomas may also be detected incidentally when patients are being worked up radiologically for other reasons.…”

Section: Discussionmentioning

confidence: 69%

Lymphoid neoplasms of the urinary tract and male genital organs: a clinicopathological study of 40 cases

Schniederjan

Osunkoya

2009

Modern Pathology

View full text Add to dashboard Cite

Lymphoid neoplasms of the urinary tract and male genital organs are relatively rare, comprising less than 5% of all primary extranodal lymphomas; only a handful of small case series and isolated case reports have been published describing their predominant sites and subtypes. We identified 40 patients with lymphoid neoplasms of the urinary tract and male genital organs. Hematoxylin and eosin slides and immunohistochemical stains were reviewed, and follow-up data were also obtained. Twenty-six of 40 cases (65%) were primary genitourinary lymphomas. Mean age at diagnosis was 56 years (range 4-86 years). Among renal, bladder, and ureter lymphomas, a male predominance was noted (1.6:1). The subtypes of the lymphoid neoplasms observed were diffuse large B-cell lymphoma (17 cases, 43%); Burkitt lymphoma, extranodal marginal zone lymphoma, SLL/CLL, and follicular lymphoma (4 cases, or 10% each); B-cell ALL (2 cases, 5%); B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma, mantle cell lymphoma, plasmacytoma, polymorphic post-transplant lymphoproliferative disorder, and peripheral T-cell lymphoma NOS (1 case, or 2.5% each). In most cases, the genitourinary tract was the site of initial presentation. Genitourinary tract lymphomas most commonly occurred in the kidney. B-cell non-Hodgkin's lymphomas predominated, with diffuse large B-cell lymphoma being the most common subtype in the entire group. Extranodal marginal zone lymphoma was seen only in the kidney, rather than the bladder, where it is typically thought to be more common. Although this study confirms the predominance of diffuse large B-cell lymphoma in extranodal sites, the findings also highlight the variety of lymphomas that may occur in the genitourinary tract. This diversity of subtypes affirms the importance of fully characterizing lymphomas by immunohistochemistry and other modalities, which are indispensable for accurate diagnosis.

show abstract

Bilateral primary renal lymphoma treated by surgery and chemotherapy

Cited by 30 publications

References 6 publications

Primary renal lymphoma: an unusual finding following radical nephrectomy

Primary renal lymphoma: an unusual finding following radical nephrectomy

Imaging of Renal Lymphoma: Patterns of Disease with Pathologic Correlation

Lymphoid neoplasms of the urinary tract and male genital organs: a clinicopathological study of 40 cases

Contact Info

Product

Resources

About