Bilateral retrobulbar optic neuritis with hepatitis B vaccination

Albitar, Sami; Bourgeon, B; Genin, R; Fen-Chong, M; Nguyen, Phan; Serveaux, Marianne; Atchia, H; Schohn, D

doi:10.1093/ndt/12.10.2169

Cited by 26 publications

(12 citation statements)

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“…We found no differences in a host of adverse events, including abnormalities in mineral metabolism, hospitalizations, infectious events, and cardiovascular events. In contrast to prior observational studies, we did not find an effect on anemia or related measures (33)(34)(35). We found that FGF-23 levels rose in all groups between baseline and week 12, but unlike previous studies in individuals without kidney disease, we did not find that supplementation with ergocalciferol augmented this effect (36).…”

Section: Hospitalizations and Deathcontrasting

confidence: 99%

Nutritional Vitamin D Supplementation in Dialysis

Bhan¹,

Dobens²,

Tamez³

et al. 2015

Clinical Journal of the American Society of Nephrology

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Results Baseline characteristics were similar across all arms, with overall mean6SD 25(OH)D levels of 21.966.9 ng/ml. At 12 weeks, vitamin D sufficiency (25[OH]D .32 ng/ml) was achieved in 91% (weekly), 66% (monthly), and 35% (placebo) (P,0.001). Mean 25(OH)D was significantly higher in both the weekly (49.862.3 ng/ml; P,0.001) and monthly (38.362.4 ng/ml; P=0.001) arms compared with placebo (27.462.3 ng/ml). Calcium, phosphate, parathyroid hormone levels, and active vitamin D treatment did not differ between groups. All-cause and cause-specific hospitalizations and adverse events were similar between groups during the intervention period. Lower all-cause mortality among ergocalciferol-treated participants was not statistically significant (hazard ratio, 0.28; 95% confidence interval, 0.07 to 1.19).Conclusions Oral ergocalciferol can increase 25(OH)D levels in incident hemodialysis patients without significant alterations in blood calcium, phosphate, or parathyroid hormone during a 12-week period.

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Section: Hospitalizations and Deathcontrasting

confidence: 99%

Nutritional Vitamin D Supplementation in Dialysis

Bhan¹,

Dobens²,

Tamez³

et al. 2015

Clinical Journal of the American Society of Nephrology

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“…Post-vaccination optic neuritis has been reported with vaccination against influenza, hepatitis B, anthrax, and meningococcus infection in non-HIV-infected patients as case reports. [6][7][8][9][10][11] It is, however, difficult to distinguish a coincidental temporal association from a true causal association merely based on individual case reports. A multicenter, randomised, double-blind, placebocontrolled trial of influenza vaccination in patients with MS found no increased exacerbation rate, nor a change in disease course over a period of 6 months postvaccination.…”

Section: Commentmentioning

confidence: 99%

Retrobulbar optic neuritis after Hepatitis A vaccination in a HIV-infected patient

Huang

Lim

et al. 2009

Eye

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“…[31,[82][83][84][85][86][87][88][89][90][91][92][93][94][95] Several possible explanations for demyelination in hepatitis B disease or following hepatitis B vaccination have been suggested. One implicates the role of immune complexes in inciting an inflammatory demyelination of nervous tissue.…”

Section: Other Demyelinating Diseasesmentioning

confidence: 99%

“…One implicates the role of immune complexes in inciting an inflammatory demyelination of nervous tissue. [95][96][97] Molecular mimicry (significant cross-reactivity between viral antigenic sites and normal human self-peptides) could potentially incite an autoimmune reaction. [98,99] Genetic predisposition (e.g.…”

Section: Other Demyelinating Diseasesmentioning

confidence: 99%

Safety of Routine Childhood Vaccinations

2000

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Immunisations have been one of the most cost-effective public health interventions in human history. Despite remarkable progress, several challenges face immunisation programs worldwide. Paradoxically, despite vaccines' clear effectiveness in reducing risks of diseases that were previously widely prevalent and caused substantial morbidity and mortality, current vaccination policies have become increasingly controversial due to concerns about vaccine safety. Vaccines, like other pharmaceutical products, are not entirely risk-free. While most known adverse effects are minor and self-limited, some vaccines have been associated with very rare but serious adverse effects. Because such rare effects are often not evident until vaccines come into widespread use, ongoing surveillance programs to monitor vaccine safety are needed. Such monitoring will be essential if the public is to accept the increasing number of new vaccines made possible by biotechnology. The interpretation of data from vaccine safety research is complex and is associated with some uncertainty. Effectively communicating this uncertainty and continuing to improve understanding of rare risks and risk factors are essential for "mature" immunisation programs to maintain public confidence in immunisations.

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Bilateral retrobulbar optic neuritis with hepatitis B vaccination

Cited by 26 publications

References 0 publications

Nutritional Vitamin D Supplementation in Dialysis

Nutritional Vitamin D Supplementation in Dialysis

Retrobulbar optic neuritis after Hepatitis A vaccination in a HIV-infected patient

Safety of Routine Childhood Vaccinations

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