“…Conversely, sialorrhea occurs in more than 80% of patients with Parkinson's disease or cerebral palsy [5,14,19], and many authors tried to define the correct approach in the treatment of sialorrhea. Intraparotid or submandibular glands injection of botulinum toxins [4,8,13,17], anticholinergic drugs (glycopyrrolate, scopolamine or atropine) [1,5,6,12,19], and surgical procedures (salivary gland excision, salivary duct ligation, salivary duct rerouting) [2,16] are reported as the main therapeutic strategies to this aim. Despite their efficacy in reducing overabundant salivation in noncancer patients, in clinical practice, the use of anticholinergic drugs is limited by their cardiac, neurological, gastrointestinal, and urinary side effects, and botulinum toxins or surgical procedures are considered the most suitable treatments.…”