Bilateral testicular metastases from prostatic carcinoma

Manikandan, Ramaswamy; Nathaniel, Calvin; Reeve, N L; Brough, Richard

doi:10.1111/j.1442-2042.2006.01329.x

Cited by 26 publications

(23 citation statements)

References 3 publications

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“…In 15% of cases, both testicles are affected [ 6 ]. The patient is typically asymptomatic, and the metastasis is often discovered incidentally after therapeutic orchiectomies or during autopsies.…”

Section: Discussionmentioning

confidence: 99%

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Gregorio¹,

Nollevaux²,

D’Hondt³

et al. 2017

Med Surg Urol

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Testicular metastases are rare in prostatic adenocarcinomas. The discovery is often fortuitous, and they are diagnosed with a histological examination. Metastasis is often confused with a primitive testicular tumor. We describe an 86-year-old patient with metastatic prostate adenocarcinoma that affected the left testis. The metastasis was discovered after Ablatherm ® treatment. A prostatic origin must be suspected in a patient over 50 years old with testicular metastasis. This study highlights the importance of clinicopathological investigation and immunohistochemistry in determining the etiopathogenesis of testicular masses.

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Section: Discussionmentioning

confidence: 99%

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Gregorio¹,

Nollevaux²,

D’Hondt³

et al. 2017

Med Surg Urol

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“…For the cases with metastasis to the testis detected long after initiation of treatment for the prostate cancer, androgen deprivation had been continued even though they had the potential to be aggressive [5]. Manikandan et al had improved survival (four years at time of their report) in their case with the patient receiving 8 cycles of chemotherapy followed by atrasentan 10 mg/day [8]. The use of multimodal therapy in our patient presenting with testicular metastasis without prior treatment for his prostate cancer led to an improved survival of two years as against a survival of less than one year observed in other cases/ series [2].…”

Section: Discussionmentioning

confidence: 99%

Metastatic prostate cancer to the testis as an initial presentation: Management review and outcome

Kyei¹,

Vanderpuye²,

Edusei³

et al. 2016

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Metastatic prostate cancer to the testis as an initial presentation is a rare condition. Though it has been noted to be associated with poor prognosis, no treatment guideline is currently available aimed at improving the outcome. This report reviews the management of a case and its outcome. Case Report: A 47-year-old male presented with a painless swelling of the left testis and rectal discomfort of three weeks duration. He had a strong family history of prostate cancer. Examination of the scrotum revealed a left non-tender testicular mass 7x5 cm that was hard with irregular surface. A digital rectal examination revealed an enlarged and nodular prostate and seminal vesicle involvement. A histological and immunohistochemical analysis of the prostatic biopsy and specimen from an inguinal orchidectomy of the left testis confirmed a metastatic prostate cancer to the testis. After three months of combined androgen deprivation therapy, he developed progressive obstructive urinary symptoms, severe pain in the anus, and a rapid increase in size of the prostate gland being castrate resistant. He underwent three dimensional conformal radiotherapy to the whole pelvis followed by seven cycles of docetaxel based chemotherapy. Nineteen months following diagnosis, his PSA was 1.86 ng/ml. Despite normal tPSA levels, there was clinical failure with development of bilateral lower limb swelling from para-aortic lymphadenopathy at two years. The patient died after two additional cycles of docetaxel chemotherapy. IJCRI publishes Conclusion:In a young patient with prostate cancer presenting initially with testicular metastasis, aggressive management strategies as pertains for castrate resistant cases need to be initiated early to improve outcomes.

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“…Most of these are diagnosed on routine histopathological examination of testicular tissue removed for the treatment of prostate carcinoma. 3,6,8,9,12,14,15 Manikandan 2006 et al reported a case of bilateral testicular metastasis 7 years after the initial diagnosis of prostate carcinoma where the patient presented with testicular lump. 9 We report this rare case of bilateral testicular metastasis from prostate carcinoma in orchiectomy specimen done for the treatment of prostate carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…1,3,4,5,6 Testicular metastasis from PC are rare despite the proximity. 3,4,6,7,8,9,10 We report a rare case of bilateral testicular metastasis in orchiectomy specimen done for treatment of PC.…”

Section: Introductionmentioning

confidence: 98%

Bilateral Testicular Metastasis in a Case of Pros Tate Carcinoma : A Case Report

Patil¹,

Helwatkar²,

Parate³

et al. 2015

jebmh

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Prostate carcinoma is the most common malignancy in men in the world and the second leading cause of cancer death. The most common sites of metastasis are regional lymph nodes, bones, lungs, liver, bladder and brain. Testicular metastasis from Prostate carcinoma is very rare. Unilateral testicular metastasis is more common than bilateral metastasis. We report a rare case of bilateral testicular metastasis in orchiectomy specimen done for treatment of prostate carcinoma.

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Bilateral testicular metastases from prostatic carcinoma

Cited by 26 publications

References 3 publications

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Metastatic prostate cancer to the testis as an initial presentation: Management review and outcome

Bilateral Testicular Metastasis in a Case of Pros Tate Carcinoma : A Case Report

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