Bilateral thalamic tumors in children

Rocco, Concezio Di; Iannelli, Aldo

doi:10.1007/s00381-002-0609-9

Cited by 56 publications

(50 citation statements)

References 6 publications

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“…The role of adjuvant therapies such as radiotherapy, brachytherapy or chemotherapy remains unclear (2,4,14,18). Our patient has not received adjuvant treatment in any way and we can speculate that the natural progression of type III BLTG is extremely aggressive as our case died 6 months after the onset of symptoms.…”

Section: Abstract: Astrocytoma Bilateral Thalamic Glioma Biopsymentioning

confidence: 80%

“…Symptoms mainly comprise mental deterioration, personality changes, and apathy, rather than focal neurological signs (17,21). This is not the case of pediatric patients who rarely present with personality disorders even in the case of large tumors (4,8).…”

Section: █ Discussionmentioning

confidence: 99%

“…The rate of BLTG is much lower than that of unilateral thalamic glioma and cannot be objectively expressed in any way at present (4)(5)(6)(7)13).…”

Section: █ Introductionmentioning

confidence: 90%

“…Primary thalamic gliomas are rare and have been presented in recent reports with an incidence of 0.84-5.2% among all intracranial tumors (2,4,15,18).…”

Section: █ Introductionmentioning

confidence: 99%

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Bilateral thalamic glioma - case report and review

Bălaşa¹,

Balasa²,

Egyed-Zsigmond³

et al. 2014

Turkish Neurosurgery

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diagnosis reported as 3 years in patients with grade II BLTG (2,10).We present the case of a BLTG manifesting with fast progressive cognitive dysfunction leading to dementia in an elderly patient. █ CASE REpORTA 72-year-old right handed male, treated only for essential arterial hypertension stage I, presented 3 months prior to admittance, with gradual deterioration of the cognitive functions and intermittently aggressive behavior towards close relatives. The symptoms progressed gradually, with the patient not being able to perform basic everyday tasks and presenting periods of extreme agitation. █ INTRODUCTIONPrimary thalamic gliomas are rare and have been presented in recent reports with an incidence of 0.84-5.2% among all intracranial tumors (2,4,15,18).Bilateral thalamic gliomas (BLTG) constitute a unique intracranial tumoral pathology typically manifested by varying degrees of personality disorder. The rate of BLTG is much lower than that of unilateral thalamic glioma and cannot be objectively expressed in any way at present (4-7,13).Imaging in BLTG is typical and reveals large tumors with symmetrical and strictly limited involvement of bilateral thalami, without any apparent connecting tumoral tissue (2).The prognosis of BLTG is poor and a rapid fatal evolution has been observed (14) with the longest period of survival after the Bilateral thalamic glioma is extremely rare and the incidence cannot be adequately expressed. We present the case of a 72 years old male suffering from the rapid deterioration of cognitive function to moderately severe dementia in a short period of time. Magnetic resonance studies demonstrated a bilateral thalamic glioma with a minimal focal gadolinium uptake in the left thalamus. Biopsy was performed and pathology report was of anaplastic astrocytoma, WHO grade III. Radiotherapy was proposed but was rejected by the patient's relatives. The patient deceased 57 days later. We performed an extensive review of the literature and by updating the previous described series we can state that to the best of our knowledge this is the 60th case described in the literature and the second eldest patient presented. Patients suffering from this disease present a poor prognosis, the longest survival described being of 3 years in patients diagnosed with grade II bilateral thalamic glioma. Adjuvant therapy in form of radiotherapy to the thalami is most commonly used but the benefits are unclear. The natural progression of WHO grade III bilateral thalamic glioma left untreated, as can be seen from our case, has an even poorer outcome.

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Section: Abstract: Astrocytoma Bilateral Thalamic Glioma Biopsymentioning

confidence: 80%

Section: █ Discussionmentioning

confidence: 99%

“…The rate of BLTG is much lower than that of unilateral thalamic glioma and cannot be objectively expressed in any way at present (4)(5)(6)(7)13).…”

Section: █ Introductionmentioning

confidence: 90%

“…Primary thalamic gliomas are rare and have been presented in recent reports with an incidence of 0.84-5.2% among all intracranial tumors (2,4,15,18).…”

Section: █ Introductionmentioning

confidence: 99%

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Bilateral thalamic glioma - case report and review

Bălaşa¹,

Balasa²,

Egyed-Zsigmond³

et al. 2014

Turkish Neurosurgery

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“…But with improved surgical techniques, total or partial resection is now more frequently performed, particularly for noninfiltrating, low-grade tumors. [1][2][3][4][5][6][7][8][9][10][11][12][13] Additionally, children with even incompletely resected low-grade thalamic gliomas can have a 5-year overall survival rate greater than 80% with adjuvant chemotherapy and radiation. 13,14 Therefore, histologic verification is now thought to be critical for planning treatment, and, as a result, biopsy and total/subtotal resections are much more common today than in the past.…”

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confidence: 99%

Pediatric Thalamic Gliomas: An Updated Review

Gupta¹,

Shaller

McFadden³

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Neoplasms originating in the thalamus are rare overall (1% of all brain tumors); however, they comprise approximately 5% of pediatric intracranial tumors and approach 15% of all malignant pediatric intracranial tumors in some series.Objective.-To update readers about the current understanding of the diverse histology, biology, and behavior of pediatric thalamic tumors. Histologic verification is now thought to be critical for planning treatment, and, as a result, biopsy and total/subtotal resections are much more common today than in the past.Data Sources.-A PubMed search using the keywords ''pediatric þ thalamic þ glioma'' yielded 45 publications with a total of 445 cases of thalamic gliomas in patients less than 18 years of age. We found only 9 substantial institutional series tabulating all encountered thalamic histologic types in children. This survey confirmed a high proportion of astrocytomas, 81% (214 of 265), of which approximately two-thirds were diffuse astrocytomas (146 of 214) and one-third were pilocytic astrocytomas (68 of 214). Of the diffuse astrocytomas, 34% (49 of 146) were low grade (World Health Organization grade II) and 55% (81 of 146) were high grade (World Health Organization grade III or IV), making the latter subgroup the largest single category of all pediatric thalamic tumors. Oligodendrogliomas and ependymomas (mostly anaplastic in both cases) comprised 10% and 3% of all pediatric thalamic tumors, respectively.Conclusions.-Tissue diagnosis is now thought crucial for prognostication and treatment, particularly as more potentially therapeutic molecular targets are discovered. Secure diagnosis allows identification of tumors for which resection is more feasible and beneficial.

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Thalamic Gliomas

Sainte‐Rose

Crimmins

Grill

Neuro-Oncology of CNS Tumors

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Bilateral thalamic tumors in children

Cited by 56 publications

References 6 publications

Bilateral thalamic glioma - case report and review

Bilateral thalamic glioma - case report and review

Pediatric Thalamic Gliomas: An Updated Review

Thalamic Gliomas

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