Bilateral Tibial Xanthoma in a Normolipidemic Patient—Report of a Rare Case with Review of Literature

Chakravarthi, Vallabhaneni Kalyan; Aruna, E.; Rao, Damera Naveen Chandra; Rao, Diddi Ranga

doi:10.4236/ijcm.2012.33047

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Intra-lesional curettage removes all gross disease and usually is sufficient for local control. [1,[5][6]…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] A few cases have been reported in non-hyperlipidemic states termed as primary bone xanthoma. [3][4][5] Various bone lesions can present with xanthomatous appearance histologically, e.g., fibrous dysplasia, giant cell tumor, simple bone cyst, fibroma, chondroblastoma, fibrous histiocytoma, histiocytosis X and chronic osteomyelitis, [1][2]6] which makes it necessary to rule out these disorders before giving a diagnosis of bone xanthoma.…”

Section: Introductionmentioning

confidence: 99%

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Primary Bone Xanthoma: A Case Report

Singh¹,

Naidu²,

Chaturvedi³

et al. 2021

Ann of Pathol and Lab Med

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Xanthoma of bone is a rare disorder of bone which occurs due to cholesterol deposits in the bone. Clinically the patients usually present with pain or fracture of the affected bone. Radiologically it presents as a lytic lesion, often with cortical expansion or disruption. Xanthoma of bone is usually associated with hyperlipidemia but rare cases of non- hyperlipidemia xanthoma are also reported, termed as primary bone xanthoma. Here we present a rare case of a 46-year-old male who presented with pain and swelling in the right middle finger. X ray showed lytic lesion in the proximal phalanx of right middle finger. Laboratory tests showed normal lipid profile. Bone biopsy and histological examination is necessary for diagnosis and to differentiate it from Rosai–Dorfman disease, Langerhans cell histiocytosis and fibrous/post traumatic dysplasia, malignant fibrous histiocytoma, or metastatic renal cell carcinoma. A diagnosis of primary bone xanthoma was made based on histology and immunohistochemistry. The fracture was treated surgically. The case report emphasises the role of histology in diagnosis of this rare clinical entity.

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“…Intra-lesional curettage removes all gross disease and usually is sufficient for local control. [1,[5][6]…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary Bone Xanthoma: A Case Report

Singh¹,

Naidu²,

Chaturvedi³

et al. 2021

Ann of Pathol and Lab Med

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“…Frequently the presenting symptom is pain and sometimes discovered incidentally. The lesion can present as a pathological fracture also 2 .…”

Section: Case Reportmentioning

confidence: 99%

“…They are common in flat and cancellous bones and are rare in cortical bone. Very rarely they break the cortex and extend into the surrounding soft tissues 2,5,8 . They usually present between third and fifth decade of life 9 .…”

Section: Case Reportmentioning

confidence: 99%

Xanthoma of Ulna

Yaligod¹,

Mahesh²,

Rudrappa³

et al. 2013

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Skeletal xanthomas are extremely rare benign disorders with features mimicking bone tumours and their definitive diagnosis is very difficult. Patients diagnosed with primary xanthoma should be followed up regularly as they may develop dyslipidemia later. Xanthomatous degeneration occurring in other bony lesions should be differentiated with xanthomas by studying the whole specimen microscopically. A 45 year old lady presented to us with xanthoma of ulna who was a known diabetic and hypothyroid on treatment. Ours is the second case of ulnar xanthoma reported so far in the literature.

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