Bilayer and Floating-Bioadhesive Tablets: Innovative Approach to Gastroretension

Dey, Samiran; Singh, Pranjal

doi:10.22270/jddt.v1i1.26

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…The dissolution study was accomplished through utilizing USP type II dissolution apparatus, 900 mL of 0.1N hydrochloric acid with 0.075 % SLS as a medium at temperature 37 ± 2°C and 100 rpm paddle speed. 14,15,[21][22][23]…”

Section: Post-compression Evaluation Of Tabletsmentioning

confidence: 99%

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

Janugade,

Singla

2024

IJPQA

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The current research aimed to prepare and estimate bioadhesive pulsatile drug delivery system (BPDDS) of an antihypertensive drug, losartan potassium, containing the formulation of a fast-dissolving core tablet and a combination of core tablet to polymer coating to formulate (BPDDS) tablet through a direct compression procedure. The coating was completed by utilizing polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was entirely assessed for the formulations. Altogether, estimation tests were found to be inside parameters. The expected lag time for hypertension is 8 hours; hence this lag time was achieved by using a bioadhesive pulsatile system. The optimized formulation showed 8 hours lag time with appropriate mucoadhesion for an equivalent period. Therefore, the BPDDS was greatest preventative substitute for drug which are the highest absorption in the stomach and for drugs which used to treat diseases with a circadian rhythm.

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Section: Post-compression Evaluation Of Tabletsmentioning

confidence: 99%

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

Janugade,

Singla

2024

IJPQA

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“…Then it was subjected to disintegration at 28-32 cycles/minute. The time taken for complete disintegration was measured in seconds [40].…”

Section: Disintegration Timementioning

confidence: 99%

Formulation Design for Poorly Water-Soluble Drug by Using Solid Dispersion of Telmisartan for Solubility and Dissolution Rate Enhancement

Paul

2019

GJPPS

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Formulating the drug into solid dispersion (SD) by fusion method and solvent evaporation method using different grades of PEG in comparison to plain telmisartan drug with optimised solid dispersion tablets. The Preformulation studies like FTIR and DSC studies for drug excipient compatibility stated that the drug and carrier selected for the study and are compatible for further studies. SD was prepared by using the drug Telmisartan by two methods, fusion method and solvent evaporation method, eighteen formulations were prepared and characterized in terms of various parameters. The in vitro drug for all the formulations were in the range of 82.38%-95.73% for fusion method and 91.45% to 96.81% for solvent evaporation method and tablets it ranges from 95.70% to 99.40%. The in-vitro release studies have shown that the cumulative drug release values were within the range of 14.23%-94.54% for fusion method, 18.57%- 95.89% for solvent evaporation method and 14.35% - 99.53% for tablets. The fast drug release about 99.53% was found in the F22 formulation by solvent evaporation method in solid dispersion tablets in the ratio of 1:2 and drug content was found to be 99.53% and disintegration time was 1.09 seconds and all parameters were found to be greater than all other formulations.

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“…Meanwhile, the weakness of the mucoadhesive system involves the potential detachment from the mucosa triggered by gastric peristalsis. Several formulation technologies, including microspheres, tablets, beads, films, and ring capsules, have this combination characteristic (Das et al, 2021;Pawar et al, 2011;Singh et al, 2011). In this case, excipients with certain characteristics are needed to combine the two systems (Blynskaya et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Chitosan as floating-mucoadhesive polymers in gastroretentive drug delivery

Ainurofiq,

Putri Febrina Sari,

Mardhiyah

et al. 2023

SEHS

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Oral drug delivery is limited by incomplete absorption in the digestive tract. The absorption of oral drugs in the stomach is affected by several factors, including gastric residence time, which causes the drug to be unable to be retained in the stomach for a long time, causing suboptimal drug absorption. One of the drug delivery systems that can prolong contact duration within the stomach is gastroretentive drug delivery system (GRDDS). GRDDS has various advantages, notably in improving the bioavailability of drugs. Several systems are involved in the GRDDS, including the floating and mucoadhesive systems. The floating system makes the drug float so it can be retained longer in the stomach. There are two mechanisms in the floating system: the effervescent and non-effervescent mechanisms. The mucoadhesive system works by adhering to the mucus or epithelial cells of the stomach. The mechanisms of mucoadhesive systems involves two stages: the contact and consolidation stages. The combination of the floating and mucoadhesive systems is aimed to improve the efficiency and effectiveness of a preparation for prolonged retention in the stomach. The choice of polymer is one of the crucial factors affecting this system. Chitosan is a natural polymer that has been evaluated for its potential in a gastroretentive floating beads delivery system. It has various advantageous properties, such as non-toxicity, biocompatibility, and biodegradability.

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Bilayer and Floating-Bioadhesive Tablets: Innovative Approach to Gastroretension

Cited by 9 publications

References 14 publications

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

Formulation Design for Poorly Water-Soluble Drug by Using Solid Dispersion of Telmisartan for Solubility and Dissolution Rate Enhancement

Chitosan as floating-mucoadhesive polymers in gastroretentive drug delivery

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