Bilayered Antimicrobial Nanofiber Membranes for Wound Dressings via <i>in Situ</i> Cross-Linking Polymerization and Electrospinning

Huang, Yanping; Dan, Nianhua; Dan, Weihua; Zhao, Weifeng; Bai, Zhongxiang; Yang, Changkai

doi:10.1021/acs.iecr.8b03122

Cited by 30 publications

(14 citation statements)

References 73 publications

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“…Then, PCL was electrospun as the biocompatible inner layer that directly contacts the wound, while the hydrophilic PCL/PMTA layer was placed as the external layer as the antibacterial layer with strong activity E. coli and S. aureus . The electrospun bilayered fibrous mats did not release any toxic agents and so are promising candidates for antimicrobial wound dressings [121] . PCL/sulfonated keratin co-electrospun fibrous membranes were prepared and studied as wound dressing candidates.…”

Section: Biomaterials For Wound Managementmentioning

confidence: 99%

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Okur

Karantas

Şenyiğit

et al. 2020

Asian Journal of Pharmaceutical Sciences

227

115

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Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process. Wounds can mainly be categorized as acute or chronic. It is well referred that the acute wound displays normal wound physiology while healing, in most cases, is seemed to progress through the normal phases of wound healing. On the other hand, a chronic wound is physiologically impaired. The main problem in wound management is that the majority of wounds are colonized with microbes, whereas this does not mean that all wounds will be infected. In this review, we address the problems that clinicians face to manage while treat acute and chronic wounds. Moreover, we demonstrate the pathophysiology, etiology, prognosis and microbiology of wounds. We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment. In addition, authors review researches which included the use of gels and dermal films as wound healing agents. It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards. However, are the current strategies as desirable as medical society wish?

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Section: Biomaterials For Wound Managementmentioning

confidence: 99%

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Okur

Karantas

Şenyiğit

et al. 2020

Asian Journal of Pharmaceutical Sciences

227

115

View full text Add to dashboard Cite

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“…3 Moreover, wound dressings play an important role in wound healing, extraction of excess fluid around the wound, disinfection of external microorganisms, and accelerating the healing process. 8,9 Recently, multilayer nanofibrous mats have been more commonly used than commercial models due to their distinctive features compared to pristine nanofibrous mats.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Double-Layer Wound Dressing Based on Chitosan/Polyvinyl Alcohol/Copper: In vitro and in vivo Assessment

Lemraski

Jahangirian

Dashti

et al. 2021

IJN

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Purpose: Today, the development of wounds and their side effects has become a problematic issue in medical science research. Hydrogel-based dressings are some of the best candidates for this purpose due to their ability to keep the wound bed clean, as well as provide proper moisture, tissue compatibility and an antimicrobial effect for wound healing. On the other hand, copper and its compounds have been used experimentally for many years in studies as an antimicrobial substance. Various studies have been performed determining the antimicrobial properties of this element, during which significant effects on infection have been shown. Methods: Chitosan/polyvinyl alcohol/copper nanofibers were successfully prepared by incorporating Cu onto a polymer electrospun using an electrospinning technique. A doublelayer nanofiber composed of poly(vinyl alcohol) and chitosan incorporated with Cu nanoparticles as a protective layer and a second layer composed of polyvinylpyrrolidone (PVP) nanofibers which was adjacent to the damaged cells was prepared. The prepared nanofiber was characterized by TGA, FT-IR, TEM, SEM-EDS, and X-ray powder diffraction. The antimicrobial efficiency of the nanofibers was demonstrated through biological tests on some Gram-positive and Gram-negative bacteria. Finally, the prepared hydrogel formulations were prepared to evaluate their effect on the healing process of rat open wounds. Results: In this study, data from SEM, TEM, EDS, and XRD confirmed the formation of uniform fibers with nanodiameters and the presence of Cu nanoparticles onto the electrospun nanofibers. The antibacterial activity of copper was observed against all of the selected bacteria, but the Grampositive bacteria were more sensitive compared to Gram-negative bacteria. Conclusion:According to the obtained results, the hydrogel wound dressing prepared in this research can be effective in caring for open wounds in the early stages of wound healing and preventing the occurrence of prolonged open wounds.

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“…The cytotoxicity of the materials was determined by the MTT method. 64 Cells were seeded onto samples at a density of 1 × 10 4 per milliliter, and then incubated for 1, 3, and 5 days. The optical density (OD) was measured with a microplate reader (model 550, Bio Rad Corp., America) at a wavelength of 492 nm.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

Wang

Gong

et al. 2020

ACS Omega

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Infection is a common complication in the process of wound management. An ideal wound dressing is supposed to reduce or even prevent the infection while promoting wound healing. A porcine acellular dermal matrix (pADM) has been already used as a wound dressing in clinic due to its capacity to accelerate wound healing. However, not only is pure pADM not antibacterial, its mechanical properties are poor. In this study, an antibacterial pADM with good performance was prepared by adding two natural products as modifiers, quercetin (QCT) and tea tree oil (TTO). The result of Fourier-transform infrared (FTIR) proved that the addition of modifiers did not break the natural triple-helical structure of collagen. Meanwhile, the results of differential scanning calorimetry (DSC), thermogravimetric analysis (TG), mechanic experiment, and enzymatic degradation demonstrated that pADM handled with QCT and TTO (termed QCT–TTO–pADM) had better thermal stability, mechanical strength, and resistance to enzymatic degradation than pADM. Meanwhile, QCT–TTO–pADM had excellent antibacterial activity and showed an antibacterial rate of over 80%. Furthermore, in the cytocompatibility analysis, QCT–TTO–pADM had no side effects on the adhesion, growth, and proliferation of fibroblasts. QCT–TTO–pADM could even accelerate wound healing more efficiently than pADM and glutaraldehyde-modified pADM (GA-pADM). In conclusion, QCT–TTO–pADM was a potential antibacterial wound dressing with good performance.

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Bilayered Antimicrobial Nanofiber Membranes for Wound Dressings via in Situ Cross-Linking Polymerization and Electrospinning

Cited by 30 publications

References 73 publications

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Antimicrobial Double-Layer Wound Dressing Based on Chitosan/Polyvinyl Alcohol/Copper: In vitro and in vivo Assessment

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

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