Recent trends on wound management: New therapeutic choices based on polymeric carriers

Abstract

Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process. Wounds can mainly be categorized as acute or chronic. It is well referred that the acute wound displays normal wound physiology while healing, in most cases, is seemed to progress through the normal phases of wound healing. On the other hand, a chronic wound is physiologically impaired. The main problem in wound management is that the majority of wounds are colonized with microbes, whereas this does not mean that all wounds will be infected. In this review, we address the problems that clinicians face to manage while treat acute and chronic wounds. Moreover, we demonstrate the pathophysiology, etiology, prognosis and microbiology of wounds. We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment. In addition, authors review researches which included the use of gels and dermal films as wound healing agents. It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards. However, are the current strategies as desirable as medical society wish?

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

“…Each stage involves a cascade of events to ensure prevention of blood loss, elimination of bacterial contamination, regeneration and formation of a new skin tissue, respectively. A variation from the norm in this process results in a delay or prolongation of any of the healing stages, which in turn leads to impaired healing [ 1 ]. The interruption in the healing process may occur for a number of reasons connected to one’s lifestyle and health condition.…”

Fabrication and Characterization of Fibrous Polycaprolactone Blended with Natural Green Tea Extracts Using Dual Solvent Systems

“…A similar trend of fiber diameter reduction was observed in the acetone-DMF solvent system. The mean fiber PCL/green tea composites will favor the absorption of excess exudate from the wounds simulating the function of the ECM [13]. Further, the electrospun membrane using acetone/DMF seemingly attractive choice compared to chloroform/DMF due to its enhanced water uptake percentage.…”

In Vivo Wound Healing and In Vitro Anti-Inflammatory Activity Evaluation of Phlomis russeliana Extract Gel Formulations

“…Subsequently, the wound is diminished. The target of wound healing is either to reduce the healing time or to avail undesired complications such as scarring [30].…”

“…It can be argued that the P. russeliana gel is similarly effective as Madecassol ® gel on epithelialization, granulation tissue thickness, and angiogenesis significant for the evaluation of wound healing. Moreover, the observed in vivo wound healing can be associated with the presence of phytol, which can accelerate and enhance the wound healing [30]. Besides angiogenesis, the improvement of dermal and epidermal regeneration, which consists of well-structured epithelial layers with an absence of crusting or intraepithelial inflammatory cells, is essential for wound healing.…”