Bile Acid Signaling in Inflammatory Bowel Disease

Bromke, Mariusz A.; Krzystek−Korpacka, Małgorzata

doi:10.3390/ijms22169096

Cited by 31 publications

(18 citation statements)

References 75 publications

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“…The gut microbiota is thought to play important roles in the development of UC by regulating the pool size and composition and altering the chemical and signaling properties of BAs [ 22 , 42 , 43 ]. Therefore, we identified and quantified 27 BAs that were significantly lower in the DSS group compared to the Control group.…”

Section: Resultsmentioning

confidence: 99%

Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites

Zheng

Zhang

et al. 2022

Metabolites

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Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the gastrointestinal tract. Recent studies demonstrate that the phenolic tannin paeonol (Pae) attenuates UC in mouse models by downregulating inflammatory factors. However, its molecular mechanism for UC treatment has not been explored from the perspective of the gut microbiota and metabolomics. In this study, we investigated the effects of Pae on colonic inflammation, intestinal microbiota and fecal metabolites in 3% dextran sodium sulfate (DSS) induced BALB/c UC mice. Pae significantly improved the clinical index, relieved colonic damage, reduced cytokine levels, and restored the integrity of the intestinal epithelial barrier in UC mice. In addition, Pae increased the abundance of gut microbiota, partially reversed the disturbance of intestinal biota composition, including Lactobacillus and Bacteroides, and regulated metabolite levels, such as bile acid (BA) and short-chain fatty acid (SCFA). In conclusion, our study provides new insight on Pae remission of UC.

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Section: Resultsmentioning

confidence: 99%

Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites

Zheng

Zhang

et al. 2022

Metabolites

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“…In addition, abnormalities in synthesis, metabolism, and related signal-transduction pathways of bile acids (BAs) have been observed in patients with UC and T2DM. As the cometabolite of “host and gut microbiota,” BAs potentially promote the repair of intestinal mucosa and affect the secretion of intestinal hormones (e.g., GLP-1) through takeda G protein-coupled receptor 5 (TGR 5) and farnesoid X receptor (FXR) pathways ( Bromke and Krzystek-Korpacka, 2021 ; Xie et al., 2021 ). LPS molecules are vital components of the outer membrane of Gram-negative bacteria.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota: The Potential Key Target of TCM’s Therapeutic Effect of Treating Different Diseases Using the Same Method—UC and T2DM as Examples

Zhang

Liu

Yang

et al. 2022

Front. Cell. Infect. Microbiol.

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Traditional Chinese herbal medicine often exerts the therapeutic effect of “treating different diseases with the same method” in clinical practice; in other words, it is a kind of herbal medicine that can often treat two or even multiple diseases; however, the biological mechanism underlying its multi-path and multi-target pharmacological effects remains unclear. Growing evidence has demonstrated that gut microbiota dysbiosis plays a vital role in the occurrence and development of several diseases, and that the root cause of herbal medicine plays a therapeutic role in different diseases, a phenomenon potentially related to the improvement of the gut microbiota. We used local intestinal diseases, such as ulcerative colitis, and systemic diseases, such as type 2 diabetes, as examples; comprehensively searched databases, such as PubMed, Web of Science, and China National Knowledge Infrastructure; and summarized the related studies. The results indicate that multiple individual Chinese herbal medicines, such as Rhizoma coptidis (Huang Lian), Curcuma longa L (Jiang Huang), and Radix Scutellariae (Huang Qin), and Chinese medicinal compounds, such as Gegen Qinlian Decoction, Banxia Xiexin Decoction, and Shenling Baizhu Powder, potentially treat these two diseases by enriching the diversity of the gut microbiota, increasing beneficial bacteria and butyrate-producing bacteria, reducing pathogenic bacteria, improving the intestinal mucosal barrier, and inhibiting intestinal and systemic inflammation. In conclusion, this study found that a variety of traditional Chinese herbal medicines can simultaneously treat ulcerative colitis and type 2 diabetes, and the gut microbiota may be a significant target for herbal medicine as it exerts its therapeutic effect of “treating different diseases with the same method”.

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“…As the TI is the major site for BA reabsorption and the most common site for CD inflammation, subsequent TI resection results in increased colonic (secondary) BA concentrations as well as increased colonic FXR expression [ 36 ]. Activation of FXR reduces ASBT expression, thereby impeding BA reabsorption [ 37 ]. The resultant secondary BA in the colon will then stimulate electrolyte and water secretion, which increases motility and shortens the colonic transit time, producing diarrhoea and other gastrointestinal symptoms such as bloating, urgency, and faecal incontinence [ 38 ].…”

Section: Bile Acidsmentioning

confidence: 99%

Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn’s Disease

Kumar

Al-Hassi

Steed

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

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Background. Bile acids help maintain the physiological balance of the gut microbiome and the integrity of the intestinal epithelial barrier. Similarly, intestinal bacteria play a major role in bile acid metabolism as they are involved in crucial biotransformation steps in the enterohepatic circulation pathway. Understanding the relationship between bile acid signalling and the gut microbiome in Crohn’s disease can help target new and innovative treatment strategies. Aims. This review summarises the relationship between bile acids and the microbiome in Crohn’s disease and discusses potential novel therapeutic options. Methods. We performed a literature review on bile acid signalling, its effect on the gut microbiome, and therapeutic applications in Crohn’s disease. Results. Current research suggests that there is a strong interplay between the dysregulated microbiota, bile acid metabolism, and the mucosal immune system that can result in a changed immunological function, triggering the inflammatory response in Crohn’s disease. Recent studies have demonstrated an association with altering the enterohepatic circulation and activating the farnesoid X receptor signalling pathway with the use of probiotics and faecal microbial transplantation, respectively. Bile acid sequestrants have been shown to have anti-inflammatory, cytoprotective, and anti-apoptotic properties with the potential to alter the intestinal microbial composition, suggesting a possible role in inducing and maintaining Crohn’s disease. Conclusions. Active Crohn’s disease has been correlated with changes in bacterial concentrations, which may be associated with changes in bile acid modification. Further research should focus on targeting these areas for future therapeutic options.

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Bile Acid Signaling in Inflammatory Bowel Disease

Cited by 31 publications

References 75 publications

Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites

Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites

Gut Microbiota: The Potential Key Target of TCM’s Therapeutic Effect of Treating Different Diseases Using the Same Method—UC and T2DM as Examples

Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn’s Disease

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