Bile Salts and Lipolysis

Abstract

Summary. The free fatty acid level was significantly reduced (P < 0.001) after intravenous administration of 10 ml of a 20% solution of sodium dehydrocholate. The activity of the postheparin lipoprotein lipase was equally significantly reduced after an injection of this compound (P < 0.001). The addition of 2.10-7 mol per 1 ml sodium dehydrocholate to the substrate mixture with postheparin plasma in vitro, reduced the lipoprotein lipase just as significantly (P < 0.001). It is thus possible that the decrease in lipacidaemia after dehydrocholate is caused by the inhibition of the lipolysis.

Interactions between bile salts, gut microbiota, and hepatic innate immunity

“…The physicochemical basis for both solubilization of lipids and facilitation of lipid digestion is the amphipathic nature of bile salts, which is due to the steric orientation of all hydrophilic moieties to one side of the molecule (Figure B) and enables formation of micelles . This feature defines the detergent activity and the critical micellar concentration (CMC) of bile salts, and is also responsible for their toxicity on cells of both the host and the microbiota, with hydrophobic bile salts showing greater toxicity.…”

Bile Salts and Lipolysis

“…The inhibition of lipoprotein lipase by bile acid salts [12] contributes to the low lipacidemia in cholestasis [4]. In man, however, the main source of free fatty acids (FFA) is adipose tissue, from which they are released chiefly by the action of hormone-sensitive lipase (HSL) and to a smaller degree by the so-called spontaneous lipolytic activity (SLA).…”