Bile Secretion and Blood Supply of the Liver

Pópper, Hans; Jefferson, N. C.; Wulkan, Eva; Necheles, H.

doi:10.1152/ajplegacy.1955.181.2.435

Cited by 12 publications

(3 citation statements)

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“…When secretin exceeds a threshold dosage, mes enteric and therefore liver blood flow increase, but no further augmenta tion of biliary secretion occurs. Earlier data of P opper et al, [12] have al ready shown that the blood supply of the liver can be markedly reduced without decrease of bile volume. Also permanent alterations of hepatic blood flow by end-to-side shunt or arterialization of the portal circulation were without influence on biliary secretion [3].…”

Section: Discussionmentioning

confidence: 90%

Secretin-Induced Bile Secretion, Bile Acid Output and Blood Supply to the Liver in the Dog

Brünner¹,

Slat²,

Kretschmer³

et al. 1975

Eur Surg Res

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Bile secretion and blood flow in the portal vein and the hepatic artery were determined in cholecystectomized anesthetized dogs before and during continuous infusion of varying doses of secretin. Secretin increases bile volume without alteration of bile acid output. Hepatic arterial flow was not altered by any dose. However, high doses of secretin increased portal venous blood flow significantly. It is concluded that secretin action on liver blood flow mirrors mainly superior mesenteric arterial vasodilation and seems to be a rather pharmacologic than a physiologic response. Bile secretion is not influenced by changes of hepatic blood flow in the physiologic range.

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Section: Discussionmentioning

confidence: 90%

Secretin-Induced Bile Secretion, Bile Acid Output and Blood Supply to the Liver in the Dog

Brünner¹,

Slat²,

Kretschmer³

et al. 1975

Eur Surg Res

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“…In fact, pentothal sodium has been found to augment hepatic bile secretion (Erlinger and Dhumeaux 1974). Circulatory depressive effects of SP cannot explain the bile flow reduction since even extreme hypoperfusion evidently does not affect bile flow (Popper et a/. 1955, Fisher, Lee and Fedor 1958, Brauer 1965.…”

Section: Discussionmentioning

confidence: 99%

Anticholeretic effect of substance P in anesthetized dogs

Holm

Thulin

Hellgren

1978

Acta Physiologica Scandinavica

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Nine anesthetized dogs were provided with acute common duct fistulas after exclusion of the gallbladder. Synthetic Substance P was administered as caval infusions in a dosage of 0.5-20 ng x kg-1 x min-1, duration 10 min. The output of hepatic bile, sodium and amylase decreased during infusion by 40-52 per cent at the highest doses. After termination of infusion all 3 parameters increased by 19-60 per cent above the basal level. The biliary concentration of sodium was constant, while that of amylase increased during infusion. The responses were dose-related. The anticholeresis induced by substance P might be due to inhibition of the canalicular bile fraction, which presumably is mediated by active sodium transport and independent of bile salt excretion.

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“…Hepatic artery ligation in the dog does not change basal bile flow (2). In Rappoport's (3) acinus model, hepatocytes close to the axial terminal vascular branches (zone I) are the first to be supplied with fresh blood rich in oxygen and nutrients, while hepatocytes around the central vein (zone III) are the last to be bathed with blood poor in oxygen and nutrients.…”

mentioning

confidence: 99%