Bile Sensing: The Activation of Vibrio parahaemolyticus Virulence

Letchumanan, Vengadesh; Chan, Kok‐Gan; Khan, Tahir Mehmood; Bukhari, Sarah I.; Mutalib, Nurul Syakima Ab; Goh, Bey Hing; Lee, Learn‐Han

doi:10.3389/fmicb.2017.00728

Cited by 30 publications

(29 citation statements)

References 50 publications

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“…[5,83,84] , Vibrio sp. [85][86][87][88][89][90][91] , and Salmonella sp. [92][93][94][95][96] that commonly affect human and animal health.…”

Section: Resultsmentioning

confidence: 99%

Decoding the mystery of how bacteria “talk”: Among Gram-negative microorganisms

Tan¹,

Law²,

Letchumanan³

et al. 2019

Prog Micobes Mol Biol

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To date, microbial diversity is still the least well understood component of biodiversity. Bacteria are the most abundant microorganisms where most species are often found ubiquitous. Microorganisms such as bacteria are diverse in their impacts such as in spreading of infectious diseases or play a valuable role in biotechnological purposes. Hence, it is interesting to gain a look upon the ways where bacteria regulate their daily processes in the environment. Bacteria communicate with each other through extracellular signalling molecules or also known as autoinducers (AIs) that are produced, detected and show response. This process is termed as quorum sensing (QS) which indicates that bacteria do communicate in order to perform various physiological activities. QS enable bacteria to have the advantages that are unattainable as individual bacterial cell. This review emphases on the characteristics of quorum sensing (QS) and its benefits in understanding different kind of bacterial QS-dependent activities. This fundamental insight from QS system will enable us to manage bacterial activities by targeting their communication circuit.

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“…[5,83,84] , Vibrio sp. [85][86][87][88][89][90][91] , and Salmonella sp. [92][93][94][95][96] that commonly affect human and animal health.…”

Section: Resultsmentioning

confidence: 99%

Decoding the mystery of how bacteria “talk”: Among Gram-negative microorganisms

Tan¹,

Law²,

Letchumanan³

et al. 2019

Prog Micobes Mol Biol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similarly, responses between infectious diseases and energy metabolism pathways were divergent in the gut microbiota of Vibrio-infected shrimp (Zhu et al, 2016). It has been proposed that changes in metabolic pathways are correlated with variations in their functions (Letchumanan et al, 2017). Therefore, Vp colonization markedly altered gut microbial function in the mice resulting in the effects on the progression of infection.…”

Section: Discussionmentioning

confidence: 99%

Vibrio parahaemolyticus Infection in Mice Reduces Protective Gut Microbiota, Augmenting Disease Pathways

Wang

Deng

et al. 2020

Front. Microbiol.

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Vibrio parahaemolyticus (Vp), a major food-borne pathogen, is responsible for severe infections such as gastroenteritis and septicemia, which may be accompanied by lifethreatening complications. While studies have evaluated factors that affect the virulence of the pathogen, none have investigated the interaction of Vp with gut microbiota. To address this knowledge gap, we compared the effect of Vp on gut bacterial community structure, immunity, liver and kidney function, in pseudo germ-free (PGF) mice and normal (control) mice. Significant damage to the ileum was observed in normal mice compared with the PGF mice. The inflammatory factors IL-1β, IL-6, and TNF-α in normal mice were ∼2.5-fold higher than in the PGF mice, and liver (ALT, AST, ALP) and kidney (BUN) function indices were ∼1.6-fold higher. The Vp infection substantially reduced species composition and richness of the gut microbial communities. In particular, there was a shift in keystone taxa, from protective species of genera Bacteroides, Lactobacillus, Bifidobacterium, and Akkermansia in the gut of control mice to opportunistic pathogens Enterobacteriaceae, Proteus, Prevotella, and Sutterella in Vp-infected mice, thus affecting microbiota-related biological functions in the mice. Specifically, pathways involved in infectious diseases and ion channels were significantly augmented in infected mice, while the pathways involved in metabolism, digestion and cell growth declined. We propose that the normal mice are more prone to Vp infection because of the alteration in gut-microbe-mediated functions. All these effects reduce intestinal resistance, with marked damage to the gut lining and pathogen leakage into the blood culminating in liver and kidney damage. These findings greatly advance our understanding of the mechanisms underlying interactions between Vp, the gut microbiota and the infected host.

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“…Due to excessive use of antibiotics in the aquaculture sector, the incidence of resistance accelerated, mostly among foodborne pathogens such as Vibrio sp. [15][16][17][18][19][20][21][22][23] , Listeria sp. [24][25][26] , and Salmonella sp.…”

Section: Introductionmentioning

confidence: 99%

Genome sequence of Vibrio sp. OULL4 isolated from shellfish

Letchumanan¹,

Tan²,

Yin³

et al. 2020

Prog Micobes Mol Biol

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The members of Vibrionaceae family are Gram-negative bacterium are ubiquitous in marine and estuarine environments. This diverse group of bacteria include many pathogenic strains that potentially cause infection to humanand aquaculture animals. Vibrio cholerae, Vibrio parahaemolyticus and Vibrio vulnificus are among the few recognized as a major, worldwide cause gastroenteritis, particularly in countries where seafood consumption is high. The control of these vibrios has been a hurdle due to the rising numbers of antibiotic resistant strains in the environments. We report the genome sequence of Vibrio sp. OULL4 isolated from shellfish. The availability of this genome sequence will facilitate the study of its antimicrobial traits, as well as add our knowledge of Vibrio sp. diversity and evolution.

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Bile Sensing: The Activation of Vibrio parahaemolyticus Virulence

Cited by 30 publications

References 50 publications

Decoding the mystery of how bacteria “talk”: Among Gram-negative microorganisms

Decoding the mystery of how bacteria “talk”: Among Gram-negative microorganisms

Vibrio parahaemolyticus Infection in Mice Reduces Protective Gut Microbiota, Augmenting Disease Pathways

Genome sequence of Vibrio sp. OULL4 isolated from shellfish

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