Biliary Cystadenocarcinoma Arising From Benign Cystadenoma

Lei, Shize; Howard, John M.

doi:10.1001/archsurg.1992.01420120112019

Cited by 16 publications

(6 citation statements)

References 3 publications

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“…In 1970, this transformation was demonstrated in rats fed on an aflatoxin diet 36 . The potential for malignant transformation from non‐invasive to invasive BMCN has also been documented retrospectively on review of serial CT imaging in a few individuals 15,37–39 . This type of invasive BMCN is noted to have a characteristic mesenchymal stroma and a much higher predilection for females, and to follow a relatively indolent course in most patients 2,40 …”

Section: Resultsmentioning

confidence: 99%

“…36 The potential for malignant transformation from non-invasive to invasive BMCN has also been documented retrospectively on review of serial CT imaging in a few individuals. 15,[37][38][39] This type of invasive BMCN is noted to have a characteristic mesenchymal stroma and a much higher predilection for females, and to follow a relatively indolent course in most patients. 2,40 The presence of ovarian stroma in BMCNs suggests a correlation with ovarian MCNs and has led to the hypothesis of an embryonal origin.…”

Section: Rare Presentationsmentioning

confidence: 99%

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Invasive biliary mucinous cystic neoplasm: a review

Simo¹,

McKillop²,

Ahrens

et al. 2012

HPB

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Section: Resultsmentioning

confidence: 99%

Section: Rare Presentationsmentioning

confidence: 99%

Invasive biliary mucinous cystic neoplasm: a review

Simo¹,

McKillop²,

Ahrens

et al. 2012

HPB

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“…If BCA is suspected on imaging, surgery is indicated even if the patient is asymptomatic [ 1 , 24 , 28 , 39 , 52 , 54 ]. The extent of resection remains to be determined, as partial resection with occasional ablation of the residual cyst using electrocautery or argon beam coagulation and/or omentopexy, lobectomy, wedge resection, and enucleation have all been reported [ 16 , 17 , 28 , 29 , 55 – 57 ]. Pinson et al have reported cyst enucleation without late recurrence and mortality [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other limited procedures like aspiration, fenestration, internal drainage, sclerotherapy, and partial resection are associated with extremely high recurrence ranging from 90 to 100%, compared to 0 to 10% with formal resection [ 4 , 14 , 16 , 20 , 52 , 55 , 58 – 61 ]. In our series, all of our patients had formal resection with no recurrence after a median follow-up of 13 (IQ 6.5–15.7) years.…”

Section: Discussionmentioning

confidence: 99%

Outcome following Resection of Biliary Cystadenoma: A Single Centre Experience and Literature Review

Pitchaimuthu

Aidoo-Micah

Coldham

et al. 2015

International Journal of Hepatology

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Background. Biliary cystadenomas (BCAs) are rare, benign, potentially malignant cystic lesions of the liver, accounting for less than 5% of cystic liver tumours. We report the outcome following resection of biliary cystadenoma from a single tertiary centre. Methods. Data of patients who had resection of BCA between January 1993 and July 2014 were obtained from liver surgical database. Patient demographics, clinicopathological characteristics, operative data, and postoperative outcome were analysed. Results. 29 patients had surgery for BCA. Male : female ratio was 1 : 28. Clinical presentation was abdominal pain (74%), jaundice (20%), abdominal mass (14%), and deranged liver function tests (3%). Cyst characteristics included septations (48%), wall thickening (31%), wall irregularity (38%), papillary projections (10%), and mural nodule (3%). Surgical procedures included atypical liver resection (52%), left hemihepatectomy (34%), right hemihepatectomy (10%), and left lateral segmentectomy (3%). Median length of stay was 7 (IQ 6.5–8.5) days. Two patients developed postoperative bile leak. No patients had malignancy on final histology. Median follow-up was 13 (IQ 6.5–15.7) years. One patient developed delayed biliary stricture and one died of cholangiocarcinoma 11 years later. Conclusion. Biliary cystadenomas can be resected safely with significantly low morbidity. Malignant transformation and recurrence are rare. Complete surgical resection provides a cure.

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“…32 In humans they have been reported to arise from malignant transformation of biliary cystadenomas and can only be differentiated from the latter with histopathology due to a significant overlap in the appearance of the two tumours on ultrasound. 36,37…”

Section: Abnormalities Of the Livermentioning

confidence: 99%

Feline abdominal ultrasonography: what’s normal? what’s abnormal? The liver

Griffin

2018

Journal of Feline Medicine and Surgery

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Practical relevance: Abdominal ultrasound plays a vital role in the diagnostic work-up of many cats presenting to general and specialist practitioners. Ultrasound examination of the liver can be key in the diagnosis of diseases such as hepatic lipidosis and hepatic neoplasia. Clinical challenges: Despite ultrasonography being a commonly used modality, many practitioners are not comfortable performing an ultrasound examination or interpreting the resulting images. Even differentiating between normal variation and pathological changes can be challenging for all but the most experienced. When assessing the liver via ultrasound, a diffuse alteration in liver echogenicity may be difficult to detect unless the change is marked and, although comparisons can be made with the spleen and kidneys, this relies on these organs being normal. Equipment: Ultrasound facilities are readily available to most practitioners, although use of ultrasonography as a diagnostic tool is highly dependent on operator experience. Aim: This review, the first in an occasional series on feline abdominal ultrasonography, discusses ultrasonographic examination of the normal and diseased liver, with focus on the liver parenchyma. It is aimed at general practitioners who wish to improve their knowledge of and confidence in feline abdominal ultrasound and is accompanied by high-resolution images. Ultrasound-guided sampling of the liver is also covered. Future articles will discuss the biliary tree and hepatic vascular anomalies. Evidence base: Information provided in this article is drawn from the published literature and the author’s own clinical experience.

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Biliary Cystadenocarcinoma Arising From Benign Cystadenoma

Cited by 16 publications

References 3 publications

Invasive biliary mucinous cystic neoplasm: a review

Invasive biliary mucinous cystic neoplasm: a review

Outcome following Resection of Biliary Cystadenoma: A Single Centre Experience and Literature Review

Feline abdominal ultrasonography: what’s normal? what’s abnormal? The liver

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