Outcome following Resection of Biliary Cystadenoma: A Single Centre Experience and Literature Review

Abstract

Background. Biliary cystadenomas (BCAs) are rare, benign, potentially malignant cystic lesions of the liver, accounting for less than 5% of cystic liver tumours. We report the outcome following resection of biliary cystadenoma from a single tertiary centre. Methods. Data of patients who had resection of BCA between January 1993 and July 2014 were obtained from liver surgical database. Patient demographics, clinicopathological characteristics, operative data, and postoperative outcome were analysed. Results. 29 patients had surgery for BCA. Male : female ratio was 1 : 28. Clinical presentation was abdominal pain (74%), jaundice (20%), abdominal mass (14%), and deranged liver function tests (3%). Cyst characteristics included septations (48%), wall thickening (31%), wall irregularity (38%), papillary projections (10%), and mural nodule (3%). Surgical procedures included atypical liver resection (52%), left hemihepatectomy (34%), right hemihepatectomy (10%), and left lateral segmentectomy (3%). Median length of stay was 7 (IQ 6.5–8.5) days. Two patients developed postoperative bile leak. No patients had malignancy on final histology. Median follow-up was 13 (IQ 6.5–15.7) years. One patient developed delayed biliary stricture and one died of cholangiocarcinoma 11 years later. Conclusion. Biliary cystadenomas can be resected safely with significantly low morbidity. Malignant transformation and recurrence are rare. Complete surgical resection provides a cure.

Clinicopathological features and post-resection outcomes of biliary cystadenoma and cystadenocarcinoma of the liver

“…Treatment of BCTs must be surgical resection whenever possible due to a potential malignant degeneration of these lesions. 18 19 In the present study, all patients received surgical resection including liver resection or complete cyst excision. Many investigations, including this study, showed that post-resection prognosis of BCA and BCAC is very favourable if complete surgical resection (R0 resection) is performed.…”

Diagnostic Challenge in a Cystic Lesion of the Epigastrium: A Case Report

“…The enigma of this present case revolves whether its origin from liver or pancreas, hence determining the choice of surgical intervention and patient's overall outcomes (8). The surgical intervention in liver pathology only renders on liver resection specifically left hemihepatectomy as in this reviewed case.…”

Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway

“…As an extracted monomer of plants, PTS has also been proven to have antitumor effects in various cancers, including cancers of the bladder 20 , lung 17 , breast 12 , 13 , prostate 14 , lymphomas 21 , and oral mucosa 22 . The potential mechanisms of PTS include inhibiting tumor cell proliferation and migration 15 , 20 , 21 , inducing cell cycle arrest 12 , 21 , accelerating apoptosis 12 , 17 , 21 , 22 , and inhibiting metastasis 40 , 41 . Moreover, PTS can inhibit the EMT process of breast cancer with the long non-coding RNAs 42 .…”