Biliary Microbiota and Bile Duct Diseases

Klabukov, Ilya; Lyundup, Alexey; Dyuzheva, T. G.; Tyakht, Alexander

doi:10.15690/vramn787

Cited by 3 publications

References 45 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Elements for Systems Medicine of Cholangiopathies

Klabukov

2020

Materials of the 14th International Scientific Conference "System Analysis in Medicine" (SAM 2020)

View full text Add to dashboard Cite

The approach to system analysis of bile duct dysfunctions based on analysis of multi-omics data of cholangiocytes is considered. There is suggested that changes in intercellular interactions in tissues of the bile duct cause phenotypic manifestations of the cholangiopathies in the changes in cholangiocyte regulation, which can be evaluated by analysis of changes in the molecular composition of the bile.

show abstract

Elements for Systems Medicine of Cholangiopathies

Klabukov

2020

Materials of the 14th International Scientific Conference "System Analysis in Medicine" (SAM 2020)

View full text Add to dashboard Cite

show abstract

Microbiota and child health: objectives of medical practice

Харитонова

Grigoriev

Папышева

et al. 2022

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

The microbiota plays a key role in the physiology and maintenance of homeostasis in the child’s body. It is important to know the processes of formation of the intestinal microbiota that begin in utero. The baby continues to receive the mother’s microflora during childbirth and breastfeeding. The results of molecular genetic studies indicate that the most intensive process of microbial colonization of a child is associated with dietary habits. The main factor in maintaining the stability and resistance of normobiota is microbial autometabolites. The most promising areas of probiotic biotechnology and the development of metabolic probiotics (metabiotics), probiotics in combination with prebiotics (synbiotics) are considered. Understanding the processes of formation of intestinal microflora allows developing effective methods for the prevention and correction of microecological and motor disorders of the gastrointestinal tract in the age aspect.

show abstract

Conservatism and divergence in the semiotics cholelithiasis

Штыгашева

Агеева

Chmykhalo

2023

jour

View full text Add to dashboard Cite

The aim of the study was to analyze the patterns associated with the risk of developing gallstone disease. Material and methods. The selection of signs of metabolic syndrome among patients of the hospital contingent with cholelithiasis, depending on gender and age, was carried out. There are 271 patients in the general population, of which 227 are women and 49 are men. Statistical processing of research results using the Statistica 8.0 applied software package. Results. Differences in etiology and pathogenesis lead to divergence of the phenotype of patients with cholelithiasis. At the same time, the conservatism of significant risk factors for the development of the disease remains. These include ethnic and sexual dimorphism: Caucasians are twice as likely to suffer from gallstone disease than the Khakass (7.3 and 3.4%, respectively). The incidence of gallstones in women is 8.6% (Caucasians - 10.9%; Khakaski - 6.2%). The indicators for women are 4.6 times higher than for men - 1.9% (Caucasians - 2.5%; Khakass - 1.3%). Older age: after 60 years, the number of patients increases exponentially, gender differences decrease. In the rating of comorbidities, the following are most often recorded: abdominal obesity (92.3% of patients), excess body weight (87.8%); violation of carbohydrate metabolism (86.4%), hypertension (81.7%), atherogenic dyslipidemia (50.6%) and NAFLD (23.6%). Conclusion. Together with conservative factors of susceptibility to gallstones that cannot be modified (age increase, female sex, heredity), a pathological phenotype known as metabolic syndrome is often formed. An increase in the frequency of gallstones is associated with variable combinations of metabolic syndrome components. Early detection of these signs can be used to predict and prevent the disease, since they are all modified to one degree or another. In addition, along with the conventional criteria for metabolic syndrome, the expression of gallstone disease has been established, which makes it possible to consider it a full-fledged sign.

show abstract

Biliary Microbiota and Bile Duct Diseases

Cited by 3 publications

References 45 publications

Elements for Systems Medicine of Cholangiopathies

Elements for Systems Medicine of Cholangiopathies

Microbiota and child health: objectives of medical practice

Conservatism and divergence in the semiotics cholelithiasis

Contact Info

Product

Resources

About