Bilirubin: an Animal Pigment in the Zingiberales and Diverse Angiosperm Orders

Pirone, Cary

doi:10.25148/etd.fi10122201

Cited by 3 publications

(5 citation statements)

References 44 publications

(46 reference statements)

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“…This became known as the only human compound that is found in a plant. This research found that in mature aril tissue bilirubin was present as granular bodies irregularly distributed throughout the cell (Pirone, 2010).…”

Section: Introductionmentioning

confidence: 78%

Effect of Strelitzia nicolai seed arils containing bilirubin on Sprague Dawley rats

Dwarka

Singh

Thaver

et al. 2019

IJAR

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The discovery of the only human pigment bilirubin in the arils of Strelitzia nicolai, has opened up a new avenue in medical sciences. Previously, bilirubin was regarded as a toxic compound. Conversely, current case studies show somewhat pre-eminent levels of bilirubin in the body can act as a powerful antioxidant. This study attempted to provide a basis for identifying potential acute toxicities related to arils that comprise bilirubin. Twelve Sprague Dawley rats were divided into four groups. Group A was the control and was administered 1% Tween 20. The other groups were orally dosed with the seed aril extract (250ìg/ml/kgbwt) once a day. After 24 hours, 48 hours and 72 hours one experimental group and the control were sacrificed. Haematological and histological studies indicated a possibility of kidney damage. However, the possibility of the extract causing this damage can be ruled out because this trend was seen in the control groups as well. This study reveals that an acute trial is insufficient in order to determine the toxicity of this extract. Further chronic studies need to be carried out.

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Section: Introductionmentioning

confidence: 78%

Effect of Strelitzia nicolai seed arils containing bilirubin on Sprague Dawley rats

Dwarka

Singh

Thaver

et al. 2019

IJAR

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“…Two other species in the Strelitziaceae, Phenakospermum guyanense (A.Rich.) and S. reginae, contain aril pigments which co-eluted with genuine bilirubin in HPLC and had similar UV-visible spectra (Pirone, 2010). In the arils of the Strelitzia species, bilirubin was present as the principal pigment, and thus functioned to create colour.…”

Section: The Breakthrough Of the Only Animal Pigment (Bilirubin) Founmentioning

confidence: 99%

“…In the arils of the Strelitzia species, bilirubin was present as the principal pigment, and thus functioned to create colour. Previously, no tetrapyrroles were known to generate display colour in plants (Pirone, 2010). Bilirubin is therefore the initial creation of a further biosynthetic course, the tetrapyrrole pathway, to produce eye-catching colour in a plant reproductive constitution.…”

Section: The Breakthrough Of the Only Animal Pigment (Bilirubin) Founmentioning

confidence: 99%

“…After being injured directly on the skin a contusion that was black or purple (colours of haem) progressively changed to olive, the colour of biliverdin, and ultimately to yellow, the colour of bilirubin (Otterbein and Choi, 2000). Previously thought to be an "animal-only" pigment, in 2009, Florida International University researchers' (Pirone, 2010), made a breakthrough discovery in finding bilirubin in the arils of Strelitzia nicolai Regel and Koern, commonly known as the white bird of paradise. Bilirubin is a by-product from the secondary degradation of haem, the primary being biliverdin.…”

Section: Introductionmentioning

confidence: 99%

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New Insights Into the Presence of Bilirubin in a Plant Species Strelitzia Nicolai (Strelitziaceae)

Dwarka¹,

Thaver²,

Naidu³

et al. 2017

AJTCAM

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Background: The fortuitous discovery of an animal pigment bilirubin found in the plant Strelitzia nicolai has opened an enormous number of questions regarding bilirubin's formation and its ultimate function in the human body. Materials and Methods: A methodical review of bilirubin in humans and animals was carried out, information was gathered using published scientific journals, books and conference proceedings. Articles based on case studies of elevated levels of bilirubin were analysed thoroughly. Results: Even though for numerous years bilirubin was assumed to be merely a desecrate product of the heme catabolic pathway by greatest, and a likely lethal compound at worst; statistics from the last few decades clearly shows that placidly high serum bilirubin levels are robustly related to have abundant beneficial effects on the human body. Conclusion: This study reveals new insights into the presence of the only animal pigment found in Strelitzia nicolai arils, the potential advantages of bilirubin found in a plant and its therapeutic value indications. This review hopes to resuscitate researchers' credence regarding bilirubin as a toxic compound.

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“…Bilirubin is a naturally occurring organic substance synthesized both in animals and some plants [1,2]. In the animal body it is produced as a bile pigment through a natural hemolytic process.…”

Section: Introductionmentioning

confidence: 99%

Neonatal hyperbilirubinemia: Background and recent literature updates on the diagnosis and treatment

Nawaz

Aslam

Rehman

2021

PhysInt

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Hyperbilirubinemia or jaundice has been studied by many researchers because of its diverse causes and potential for toxicity especially in the neonate but to a lesser extent beyond the neonate as well. Several studies have been performed on the normal metabolism and metabolic disorders of bilirubin in last decades of the 20th century. The recent advancement in research and technology facilitated for the researchers to investigate new horizons of the causes and treatment of neonatal hyperbilirubinemia. This review gives a brief introduction to hyperbilirubinemia and jaundice and the recent advancement in the treatment of neonatal hyperbilirubinemia. It reports modifications in the previously used methods and findings of some newly developed ones. At present, ample literature is available discussing the issues regarding hyperbilirubinemia and jaundice, but still more research needs to be done.

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Bilirubin: an Animal Pigment in the Zingiberales and Diverse Angiosperm Orders

Cited by 3 publications

References 44 publications

Effect of Strelitzia nicolai seed arils containing bilirubin on Sprague Dawley rats

Effect of Strelitzia nicolai seed arils containing bilirubin on Sprague Dawley rats

New Insights Into the Presence of Bilirubin in a Plant Species Strelitzia Nicolai (Strelitziaceae)

Neonatal hyperbilirubinemia: Background and recent literature updates on the diagnosis and treatment

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