Bilirubin detection by different methods with special emphasis on biosensing: A review

Narwal, Vinay; Batra, Bhawna; Kalra, Vijay K.; Jalandra, Rekha; Ahlawat, Jyoti; Hooda, Ritu; Sharma, Minakshi; Rana, J. S.

doi:10.1016/j.sbsr.2021.100436

Cited by 20 publications

(19 citation statements)

References 45 publications

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“…The bilirubin level in blood was found to be 3–19 μg/ml. [ 63 ] The obtained LOD values for detection of bilirubin indicated that CdS–GT QDs were highly sensitive and were promising candidates for detection of bilirubin compared with many other methods or fluorescence probes used for the detection of bilirubin. [ 63 ]…”

Section: Resultsmentioning

confidence: 99%

“…[63] The obtained LOD values for detection of bilirubin indicated that CdS-GT QDs were highly sensitive and were promising candidates for detection of bilirubin compared with many other methods or fluorescence probes used for the detection of bilirubin. [63] 3.4.1 | Interference of metal ions on CdS-GT QDs biosensing probe…”

Section: Fluorescence Response Of Cds-gt Qds To Tetracycline (Tc) Rif...mentioning

confidence: 90%

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Interaction properties of biosynthesized cadmium sulphide quantum dots with human serum albumin: further investigation of antibacterial activities and sensing applications

2022

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The synthesis of small-sized quantum dots (QDs) (1-10 nm) via the green route has garnered great interest regarding their prospective use in many biological applications (diagnosis, drug delivery and in vivo sensing); this is difficult to achieve using chemical synthesis methods, which produce larger size QD particles and also require hazardous reagents. Here, we synthesized biogenic cadmium sulphide (CdS) QDs using green tea extract as the reducing agent to produce particles that were homogeneous and a smaller size of 2-4 nm. We also elucidated the (a) protein binding, (b) antibacterial use and (c) sensing applications of biogenic CdS QDs in this present work. The biosynthesized CdS QDs were found to have extensive antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Enterococcus faecalis bacterial strains. The introduction of QDs in biological medium can lead to the formation of protein-QD complexes; therefore we investigated the binding interaction of CdS QDs with the carrier protein human serum albumin (HSA) in vitro. The synthesized CdS QDs quenched the intrinsic fluorescence of HSA through a static quenching mechanism and the binding constant (K b ) was in the order of 10 4 M À1 . It was also observed that the presence of biogenic CdS QDs affected the HSA-ligand interactions in vitro. The synthesized CdS made highly effective sensors for tetracycline, rifampicin, and bilirubin with limit of detection (LOD) values of 99, 141 and 29 ng/ml, respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Fluorescence Response Of Cds-gt Qds To Tetracycline (Tc) Rif...mentioning

confidence: 90%

Interaction properties of biosynthesized cadmium sulphide quantum dots with human serum albumin: further investigation of antibacterial activities and sensing applications

2022

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“…Furthermore, with a LOD of 22 ng mL À1 , the ZnS-GT QDs were demonstrated to be a superior sensing probe for bilirubin detection (bilirubin concentration in blood 3-19 ng mL À1 ). 87 The analytical performance characteristics of the ZnS-GT QD sensing system are also contrasted with those of other published systems for the detection of bilirubin and RFP (Table S5, ESI †).…”

Section: Fluorescence Response To Rifampicin and Bilirubinmentioning

confidence: 99%

Formation of ZnS quantum dots using green tea extract: applications to protein binding, bio-sensing, anti-bacterial and cell cytotoxicity studies

et al. 2023

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“…[ 14,15 ] When the total bilirubin content is higher than 34 mol/L, hearing loss, brain damage, jaundice, cirrhosis of the liver, and other symptoms can occur and serious conditions can be life‐threatening. [ 16–18 ] Therefore, a method for the simple, accurate, and inexpensive determination of bilirubin is becoming increasingly important in medicine and pharmacology. To date, many chemical techniques have been proposed to determine the bilirubin content, including high‐performance liquid chromatography, [ 19 ] capillary electrophoresis, [ 20 ] chemiluminescence, [ 21 ] Raman spectroscopy, [ 22 ] electrochemical methods, [ 23 ] and ultraviolet (UV) spectrophotography.…”

Section: Introductionmentioning

confidence: 99%

Nitrogen‐doped carbon dots as a fluorescent probe for the highly sensitive detection of bilirubin and cell imaging

Zhang

et al. 2022

Luminescence

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Nitrogen-doped carbon dots (NCDs) with bright blue fluorescence were constructed by a hydrothermal method using sucrose and L-proline as raw materials. The NCDs were characterized by transmitted electron microscopy, X-ray diffraction, Fouriertransform infrared spectrometry, X-ray photoelectron spectroscopy, and ultravioletvisible absorption and fluorescence spectroscopy to investigate the morphology, elemental composition, and optical properties. The NCDs had good water solubility, high dispersibility with an average diameter of only 1.7 nm, and satisfactory optical properties with a fluorescence quantum yield of 23.4%. The NCDs were employed for the detection of bilirubin. A good linear response of the NCDs in the range 0.35-9.78 μM was obtained for bilirubin with a detection limit of 33 nM. The NCDs were also applied to the analysis of real samples, serum and urine, with a recovery of 95.34% to 104.66%. The low cytotoxicity and good biocompatibility of the NCDs were indicated by an MTT assay and cell imaging of HeLa cells. Compared with other detection systems, using NCDs for bilirubin detection was a facile and efficient method with good selectivity and sensitivity.

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Bilirubin detection by different methods with special emphasis on biosensing: A review

Cited by 20 publications

References 45 publications

Interaction properties of biosynthesized cadmium sulphide quantum dots with human serum albumin: further investigation of antibacterial activities and sensing applications

Interaction properties of biosynthesized cadmium sulphide quantum dots with human serum albumin: further investigation of antibacterial activities and sensing applications

Formation of ZnS quantum dots using green tea extract: applications to protein binding, bio-sensing, anti-bacterial and cell cytotoxicity studies

Nitrogen‐doped carbon dots as a fluorescent probe for the highly sensitive detection of bilirubin and cell imaging

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