Bimetallic (Ag and MgO) nanoparticles, Aloe vera extracts loaded xanthan gum nanocomposite for enhanced antibacterial and in-vitro wound healing activity

Saravanakumar, Kandasamy; Sathiyaseelan, Anbazhagan; Zhang, Xin; Choi, Miri; Wang, Myeong‐Hyeon

doi:10.1016/j.ijbiomac.2023.124813

Cited by 18 publications

(2 citation statements)

References 70 publications

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“…Saravanakumar et al reported the in vitro wound healing potential of xanthan gum nanocomposites incorporated with a combination of AgNPs, MgO-NPs, and aloe vera extracts [ 106 ]. The nanocomposites exhibited antibacterial inhibition against E. coli and B. cereus , showing 14.5 ± 0.85 mm and 15 ± 0,12 mm zones of inhibition and MIC values of 2.5 µg/mL and 0.62 µg/mL, respectively.…”

Section: Polymer-based Wound Dressings Loaded With Bioactive Materialsmentioning

confidence: 99%

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Nqoro,

Taziwa

2024

Pharmaceutics

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Wound infection due to bacterial invasion at the wound site is one of the primary challenges associated with delayed wound healing. Microorganisms tend to form biofilms that protect them from harm, leading to their multidrug resistance. The alarming increase in antibiotic resistance poses a threat to wound healing. Hence, the urgent need for novel wound dressing materials capable of managing bacterial infection is crucial for expediting wound recovery. There is considerable interest in polymeric wound dressings embedded with bioactive substances, such as metal-based nanoparticles, as potential solutions for treating microbially infected wounds. Metal-based nanoparticles have been widely used for the management of infected wounds due to their broad antimicrobial efficacy. This review focuses on polymer-based and bioactive wound dressings loaded with metal-based nanoparticles like silver, gold, magnesium oxide, or zinc oxide. When compared, zinc oxide-loaded dressings exhibited higher antibacterial activity against Gram-positive strains and silver nanoparticle-loaded dressings against gram-negative strains. However, wound dressings infused with both nanoparticles displayed a synergistic effect against both strains of bacteria. Furthermore, these dressings displayed antibiofilm activity and the generation of reactive oxygen species while accelerating wound closure both in vitro and in vivo.

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Section: Polymer-based Wound Dressings Loaded With Bioactive Materialsmentioning

confidence: 99%

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Nqoro,

Taziwa

2024

Pharmaceutics

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“…Furthermore, the in vivo studies demonstrated higher wound closure activities compared to control without nanoparticles. 226 In a recent study, chitosan/polyvinyl alcohol hydrogels loaded with FeO nanoparticles for investigation of antimicrobial properties and wound healing. Herein, the nanocomposite hydrogels demonstrated efficient control over bacterial infections in treatment of diabetic foot infections.…”

Section: Experimental Nps Incorporated Hydrogels In Delivery Of the A...mentioning

confidence: 99%

Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends

Ahmad,

Bukhari,

Hussain

et al. 2024

RSC Adv.

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Utilization of Xanthan Gum-Silver Nitroprusside Nanoparticles for Prospective Advancements in Bacteriostasis and Wound Healing

Lin,

Sathiyaseelan,

Zhang

et al. 2024

J Inorg Organomet Polym

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Bimetallic (Ag and MgO) nanoparticles, Aloe vera extracts loaded xanthan gum nanocomposite for enhanced antibacterial and in-vitro wound healing activity

Cited by 18 publications

References 70 publications

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends

Utilization of Xanthan Gum-Silver Nitroprusside Nanoparticles for Prospective Advancements in Bacteriostasis and Wound Healing

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