Bimetallic Catalyzed Synthesis of 2-Arylindoles

Marques, M. Manuel B.; Ferro, Rita; Viduedo, Nuno; Santos, A. Sofia; Royo, Beatriz; Silva, Artur M. S.

doi:10.1055/a-2035-6420

Cited by 5 publications

(3 citation statements)

References 35 publications

(71 reference statements)

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“…Marques and coworkers recently disclosed a novel one-pot bimetallic catalytic approach for the synthesis of indole derivatives using secondary alcohols and anilines as starting materials (Scheme 12) [8]. A commercially available nickel catalyst combined with a simple phosphine was investigated for the dehydrogenation of alcohol (49); a phosphine-free manganese complex was also synthesized to achieve this oxidation step.…”

Section: Bimetallic Approaches Involving Indole Scaffoldsmentioning

confidence: 99%

“…One particularly promising area of bimetallic catalysis is the synthesis of N-heterocycles, which are essential building blocks in numerous biologically active compounds and pharmaceuticals [8]. Traditional synthetic routes for N-heterocycles have some drawbacks, such as the involvement of multiple steps, harsh conditions, and the generation of significant waste.…”

Section: Introductionmentioning

confidence: 99%

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Bimetallic (or Multimetallic) Synthesis of N-Heterocycles

Reis,

Viduedo,

Raydan

et al. 2023

Catalysts

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Bimetallic (or multimetallic) catalysis has emerged as a powerful tool in modern chemical synthesis, offering improved reaction control and versatility. This review focuses on the recent developments in bimetallic sequential catalysis for the synthesis of nitrogen heterocycles, which are essential building blocks in pharmaceuticals and fine chemicals. The cooperative action of two (sometimes more) different metal catalysts enables intricate control over reaction pathways, enhancing the selectivity and efficiency of the synthesis of N-heterocyclic compounds. By activating less reactive substrates, this multimetal catalytic strategy opens new synthetic possibilities for challenging compounds. The use of catalytic materials in bimetallic systems reduces waste and improves atom efficiency, aligning with green chemistry principles. With a diverse range of metal combinations and reaction conditions, bimetallic catalysis provides access to a broad array of N-heterocyclic compounds with various functionalities. This paper highlights the significant progress made in the past decade in this topic, emphasizing the promising potential of bimetallic catalysis in drug discovery and the fine chemical industries.

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Section: Bimetallic Approaches Involving Indole Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bimetallic (or Multimetallic) Synthesis of N-Heterocycles

Reis,

Viduedo,

Raydan

et al. 2023

Catalysts

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show abstract

“…Em conclusão, foram apresentadas diversas metodologias para a síntese de iminas e seus derivados N-heterocíclicos [40,41], em particular indoles e azaindoles, tendo sido destacada a importância do desenvolvimento de novos métodos de síntese mais sustentáveis. Neste contexto, destacaram-se os estudos recentes envolvendo uma metodologia sintética bimetálica one-pot, usando catalisadores de manganês sem recurso a fosfinas.…”

Section: Desenvolvimento De Uma Estratégia Sintética Bimetálica One-p...unclassified

Catálise de Mn para a Formação Sustentável e Eficiente de Iminas: um Passo Rumo a uma Via Bimetálica One-pot para a Síntese de N-Heterociclos

Nuno Viduedo

2023

BSPQuimica

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Obteve a sua licenciatura em Química Aplicada, em 2019, na NOVA School of Science and Technology (FCT-NOVA). Obteve o mestrado em Química Bioorgânica da mesma instituição, em 2021. No ano seguinte, foi distinguido pela SPQ com o prémio para melhor tese de mestrado em Química Orgânica (2021), em Portugal. Atualmente, encontra-se a iniciar o seu doutoramento em Química Sustentável na FCT-NOVA. A sua investigação centra-se no desenvolvimento de novas abordagens sintéticas, envolvendo catálise metálica, para a construção de heterociclos de nitrogénio.

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Discovery of Novel Fluorescent Azaindoles with Cytotoxic Action in A2780 Ovarian Carcinoma Cells

Cunha,

Roma‐Rodrigues,

Ferreira

et al. 2024

ChemMedChem

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Azaindole scaffold is a privileged structure in medicinal chemistry and some derivatives have demonstrated to be potential anticancer drugs. Herein, a set of novel azaindoles, comprising the four regioisomers, bearing a morpholine (azaindoles 3a‐d) and N‐methyl‐N‐benzylamine (azaindoles 4a‐d) groups were prepared. Among these compounds, azaindoles 4 exhibited higher cytotoxicity against the ovarian cancer cell line A2780 and normal dermal fibroblasts compared to azaindoles 3. Furthermore, azaindoles 4b and 4c promoted a delay in the cell cycle of the cancer cell line, inspiring an investigation into the intracellular localization of these derivatives.

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Bimetallic Catalyzed Synthesis of 2-Arylindoles

Cited by 5 publications

References 35 publications

Bimetallic (or Multimetallic) Synthesis of N-Heterocycles

Bimetallic (or Multimetallic) Synthesis of N-Heterocycles

Catálise de Mn para a Formação Sustentável e Eficiente de Iminas: um Passo Rumo a uma Via Bimetálica One-pot para a Síntese de N-Heterociclos

Discovery of Novel Fluorescent Azaindoles with Cytotoxic Action in A2780 Ovarian Carcinoma Cells

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